CYP2B6 gene related symptoms and diseases

All the information presented here about the CYP2B6 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: ORPHANET,OMIM,HGNC,NCBIGENE, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to CYP2B6 gene

Symptoms // Phenotype % Cases
Immunodeficiency Very Common - Between 80% and 100% cases
Depressivity Very Common - Between 80% and 100% cases
Aggressive behavior Very Common - Between 80% and 100% cases
Vertigo Very Common - Between 80% and 100% cases
Insomnia Very Common - Between 80% and 100% cases

Other less frequent symptoms and clinical features

Patients with CYP2B6 gene alterations may also develop some of the following symptoms and phenotypes:
  • Commonly - More than 50% cases

  • Mania
Mendelian

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Rare diseases associated to CYP2B6 gene

Here you will find a list of rare diseases related to the CYP2B6. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


EFAVIRENZ, POOR METABOLISM OF


Description

Highly active antiretroviral therapy (HAART) has reduced mortality associated with acquired immunodeficiency syndrome (AIDS; see {609423}) by at least 70%. Efavirenz is a non-nucleoside reverse transcriptase inhibitor that is frequently prescribed with 2 nucleoside reverse transcriptase inhibitors as initial therapy for human immunodeficiency virus (HIV) infection. However, during the first weeks of therapy, up to half of patients who receive efavirenz experience CNS side effects, including dizziness, insomnia, impaired concentration, somnolence, and abnormal dreams. Severe depression, aggressive behavior, and paranoid or manic reactions may also occur, and such side effects may reflect varying efavirenz plasma concentrations. Plasma clearance of efavirenz appears slower in African Americans than in European Americans, and studies have suggested earlier virologic failure on efavirenz for both African Americans and Hispanics compared with European Americans. Efavirenz is metabolized primarily by hepatic CYP2B6, with some involvement of CYP3A (CYP3A4 ) (summary by Haas et al., 2004).

Most common symptoms of EFAVIRENZ, POOR METABOLISM OF

  • Immunodeficiency
  • Depressivity
  • Aggressive behavior
  • Vertigo
  • Insomnia


More info about EFAVIRENZ, POOR METABOLISM OF

SOURCES: OMIM


Potential gene panels for CYP2B6 gene

Efavirenz, poor metabolism of Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the CYP2B6 gene.

More info about this panel

Cytochrome P450 genotyping Panel

Germany.

By bio.logis Center for Human Genetics Diagnosticum Cytochrome P450 genotyping that also includes the following genes: CYP2B6 CYP2C19 CYP2C9 CYP2D6 CYP3A4 CYP3A5

More info about this panel

Pharmacogenetic panel Panel

Germany.

By bio.logis Center for Human Genetics Diagnosticum Pharmacogenetic panel that also includes the following genes: SLC19A1 SLCO1B1 SOD2 TPMT UGT1A1 CCR5 VKORC1 ADH1B CYP2B6 CYP2C19

More info about this panel

CYP2B6 Panel

Germany.

By MVZ Dortmund Dr. Eberhard & Partner

This panel specifically test the CYP2B6 gene.

More info about this panel

Toxicity to drugs: CYP2B6 gene sequence analysis Panel

Spain.

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases

This panel specifically test the CYP2B6 gene.

More info about this panel

CYP2B6 Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the CYP2B6 gene.

More info about this panel

YouScript Analgesic Panel

United States.

By Genelex YouScript Analgesic that also includes the following genes: CYP2B6 CYP2C9 CYP2D6 CYP3A4 CYP3A5 OPRM1

More info about this panel

CYP2B6 Panel

United States.

By Genelex

This panel specifically test the CYP2B6 gene.

More info about this panel

GeneSight Psychotropic Panel

United States.

By Assurex Health, Inc. GeneSight Psychotropic that also includes the following genes: SLC6A4 UGT1A4 UGT2B15 CYP2B6 CYP2C19 CYP2C9 CYP2D6 CYP3A4 HLA-A HTR2A

More info about this panel

Pain Medication DNA Insight Panel

United States.

By Pathway Genomics Pain Medication DNA Insight that also includes the following genes: CYP2B6 CYP2C19 CYP2C9 CYP2D6 MTHFR OPRM1

More info about this panel

Genecept Assay™ Panel

United States.

By Genomind Genomind, Inc Genecept Assay™ that also includes the following genes: BDNF SLC6A4 CACNA1C CYP2B6 CYP2C19 CYP2C9 CYP2D6 CYP3A5 ADRA2A DRD2

More info about this panel

OneOme RightMed comprehensive test Panel

United States.

By OneOme OneOme RightMed comprehensive test that also includes the following genes: SLCO1B1 SLC6A4 TPMT UGT1A1 IFNL3 NUDT15 VKORC1 CYP2B6 CYP2C18 CYP2C19

More info about this panel

Rxight Pharmacogenetics Program Panel

United States.

By MD Labs MD Labs Rxight Pharmacogenetics Program that also includes the following genes: SLCO1B1 TPMT UGT2B15 ANKK1 VKORC1 CYP2B6 CYP2C19 CYP2C8 CYP2C9 CYP2D6

More info about this panel

CYP2B6 genotyping Panel

United States.

By Alpha Genomix Laboratories

This panel specifically test the CYP2B6 gene.

More info about this panel

Susceptibility to Drugs (Efavirenz) , Sequencing CYP2B6 Gene Panel

Spain.

By Reference Laboratory Genetics

This panel specifically test the CYP2B6 gene.

More info about this panel

Methadone response Panel

India.

By Xcode Life Xcode Life Methadone response that also includes the following genes: CYP2B6 CYP3A4 DRD2 OPRM1

More info about this panel

152 Integrated Advantage NGS Solid Tumor Panel Panel

United States.

By Integrated Molecular Diagnostics Pathology, Inc. 152 Integrated Advantage NGS Solid Tumor Panel that also includes the following genes: ROS1 RRM1 SLCO1B1 BRAF BRCA1 SLC29A1 BRCA2 SMO SPARC SRC

More info about this panel

Tempus xO assay Panel

United States.

By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2

More info about this panel


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