CD3G gene related symptoms and diseases

All the information presented here about the CD3G gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: ORPHANET,HGNC,OMIM,NCBIGENE, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to CD3G gene

Symptoms // Phenotype % Cases
Failure to thrive Very Common - Between 80% and 100% cases
Abnormal intestine morphology Very Common - Between 80% and 100% cases
Decreased proportion of CD8-positive T cells Very Common - Between 80% and 100% cases
Bronchiolitis obliterans Very Common - Between 80% and 100% cases
Bronchiolitis Very Common - Between 80% and 100% cases

Other less frequent symptoms and clinical features

Patients with CD3G gene alterations may also develop some of the following symptoms and phenotypes:
  • Commonly - More than 50% cases

  • Decrease in T cell count
  • Severe combined immunodeficiency
  • Autoimmune hemolytic anemia
  • Combined immunodeficiency
  • Inflammation of the large intestine
  • Lymphopenia
  • Anemia
  • Recurrent otitis media

And 8 more phenotypes, you can get all of them using our tools for rare diseases.

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Rare diseases associated to CD3G gene

Here you will find a list of rare diseases related to the CD3G. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


COMBINED IMMUNODEFICIENCY DUE TO CD3GAMMA DEFICIENCY


Alternate names

COMBINED IMMUNODEFICIENCY DUE TO CD3GAMMA DEFICIENCY Is also known as scid-like immunodeficiency, t cell-partial, b cell-positive, nk cell-positive, cd3-gamma deficiency

Description

Combined immunodeficiency due to CD3gamma deficiency is an extremely rare genetic combined primary immunodeficiency characterized by a selective partial lymphopenia (T+/-B+NK+) phenotype and decreased CD3 complex resulting in a variable but usually mild clinical presentation ranging from asymptomatic until adulthood to high susceptibility to infections from early infancy with predominant automimmune manifestations.

Most common symptoms of COMBINED IMMUNODEFICIENCY DUE TO CD3GAMMA DEFICIENCY

  • Failure to thrive
  • Anemia
  • Immunodeficiency
  • Recurrent infections
  • Recurrent respiratory infections


More info about COMBINED IMMUNODEFICIENCY DUE TO CD3GAMMA DEFICIENCY

SOURCES: ORPHANET OMIM


Potential gene panels for CD3G gene

Combined immunodeficiency due to CD3gamma deficiency (sequence analysis of CD3G gene) Panel

Portugal.

By CGC Genetics

This panel specifically test the CD3G gene.

More info about this panel

CD3G Panel

Netherlands.

By Genome Diagnostics Laboratory University Medical Center Utrecht

This panel specifically test the CD3G gene.

More info about this panel

Severe combined immunodeficiency (SCID) panel Panel

Netherlands.

By Genome Diagnostics Laboratory University Medical Center Utrecht Severe combined immunodeficiency (SCID) panel that also includes the following genes: STAT5B STIM1 TBX1 CD40 CD40LG ZAP70 CD3D CD3E CD3G CD8A

More info about this panel

CentoICU platinum plus Panel

Germany.

By Centogene AG - the Rare Disease Company CentoICU platinum plus that also includes the following genes: RMRP BCS1L BDNF RPS19 RPS6KA3 SALL1 SCN1A SCN2A SFTPB SFTPC

More info about this panel

New Born testing (CentoICU) Panel

Germany.

By Centogene AG - the Rare Disease Company New Born testing (CentoICU) that also includes the following genes: RMRP BCS1L BDNF RPS19 RPS6KA3 SALL1 SCN1A SCN2A SFTPB SFTPC

More info about this panel

Cone-rod dystrophy type 17 Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the CD3G gene.

More info about this panel

Combined immunodeficiencies Panel Panel

Germany.

By CeGaT GmbH Combined immunodeficiencies Panel that also includes the following genes: RMRP SEMA3E STAT5B STIM1 STK4 TAPBP TBX1 THBD TNFRSF4 CD40

More info about this panel

Invitae Comprehensive Severe Combined Immunodeficiency (SCID) and Combined Immunodeficiency (CID) Panel Panel

United States.

By Invitae Invitae Comprehensive Severe Combined Immunodeficiency (SCID) and Combined Immunodeficiency (CID) Panel that also includes the following genes: STK4 TAPBP TNFRSF4 CD27 CD40LG ZAP70 CARD11 CD3D CD3E CD3G

More info about this panel

Invitae Monogenic Inflammatory Bowel Disease Panel Panel

United States.

By Invitae Invitae Monogenic Inflammatory Bowel Disease Panel that also includes the following genes: SH2D1A BTK STAT1 STAT3 STIM1 STXBP2 CD40LG WAS ZAP70 AICDA

More info about this panel

Invitae Primary Immunodeficiency Panel Panel

United States.

By Invitae Invitae Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC SEMA3E SH2D1A SH3BP2 SLC7A7 SMARCAL1 BTK STAT1 STAT2

More info about this panel

Invitae Combined Immunodeficiency (CID) Panel Panel

United States.

By Invitae Invitae Combined Immunodeficiency (CID) Panel that also includes the following genes: STK4 TAPBP TNFRSF4 CD27 CD40LG ZAP70 CARD11 CD3G CD8A LRBA

More info about this panel

CD3G Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the CD3G gene.

More info about this panel

Primary Immunodeficiency Panel Panel

Finland.

By Blueprint Genetics Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC CFB BLM SH2D1A SLC7A7 SMARCAL1 SMARCD2 SRP72 BTK

More info about this panel

Severe Combined Immunodeficiency Panel Panel

Finland.

By Blueprint Genetics Severe Combined Immunodeficiency Panel that also includes the following genes: RMRP BLM SH2D1A SMARCAL1 STAT1 STAT2 STAT3 STAT5B STIM1 STK4

More info about this panel


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