BCL6 gene related symptoms and diseases

All the information presented here about the BCL6 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,OMIM,HGNC,ORPHANET, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to BCL6 gene

Symptoms // Phenotype % Cases
Neoplasm Rare - less than 30% cases
Insulin resistance Rare - less than 30% cases
Mediastinal lymphadenopathy Rare - less than 30% cases
Skin nodule Rare - less than 30% cases
Night sweats Rare - less than 30% cases

Other less frequent symptoms and clinical features

Patients with BCL6 gene alterations may also develop some of the following symptoms and phenotypes:
  • Rarely - Less than 30% cases

  • Chronic lymphatic leukemia
  • B-cell lymphoma
  • Glucose intolerance
  • Pleural effusion
  • Meningitis
  • Lymphedema
  • Lymphoma
  • Fever

And 10 more phenotypes, you can get all of them using our tools for rare diseases.

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Rare diseases associated to BCL6 gene

Here you will find a list of rare diseases related to the BCL6. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA


Alternate names

PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA Is also known as med-dlbcl, primary mediastinal clear cell lymphoma of b-cell type, large cell lymphoma of the mediastinum, mediastinal diffuse large-cell lymphoma with sclerosis

Description

Primary mediastinal B-cell lymphoma (PMBL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL; see this term), arising from B cells of thymic origin, that affects mainly women between the ages of 20-30, that usually presents with a bulky and rapidly expanding anterior mediastinal mass, often with pleural and pericardial effusions, and that can invade the lungs, superior vena cava, pleura, pericardium, and chest wall, leading to manifestations of cough, dyspnea, and superior vena cava syndrome.


More info about PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA

SOURCES: ORPHANET

FOLLICULAR LYMPHOMA


Alternate names

FOLLICULAR LYMPHOMA Is also known as oncogene b-cell leukemia 2

Description

Follicular lymphoma is a form of non-Hodgkin lymphoma (see this term) characterized by a proliferation of B cells whose nodular structure of follicular architecture is preserved.

Most common symptoms of FOLLICULAR LYMPHOMA

  • Neoplasm
  • Fever
  • Fatigue
  • Diarrhea
  • Splenomegaly


More info about FOLLICULAR LYMPHOMA

SOURCES: OMIM ORPHANET

HIGH GRADE B-CELL LYMPHOMA WITH MYC AND/ OR BCL2 AND/OR BCL6 REARRANGEMENT



More info about HIGH GRADE B-CELL LYMPHOMA WITH MYC AND/ OR BCL2 AND/OR BCL6 REARRANGEMENT

SOURCES: ORPHANET

INTRAVASCULAR LARGE B-CELL LYMPHOMA


Alternate names

INTRAVASCULAR LARGE B-CELL LYMPHOMA Is also known as tappeiner-pfleger disease, angioendotheliomatosis proliferans systemisata, malignant angioendotheliomatosis, angiotropic large cell lymphoma, intravascular lymphomatosis

Description

Intravascular large B-cell lymphoma (IVLBCL) is a very rare form of diffuse large B-cell lymphoma (see this term) characterized by the selective growth of lymphoma cells within the lumina of small blood vessels (especially the capillaries) that most often presents with a wide range of clinical manifestations (as potentially any tissue can be involved), with patients from Western countries more frequently manifesting with neurological and cutaneous symptoms while patients from Asian countries more frequently displaying hepatosplenomegaly and thrombocytopenia. IVLBCL is characterized by an absence of lymphadenopathy, an aggressive clinical course and a poor prognosis.


More info about INTRAVASCULAR LARGE B-CELL LYMPHOMA

SOURCES: ORPHANET


Potential gene panels for BCL6 gene

Detection by FISH of BCL6 (3q27) rearrangements Panel

Portugal.

By CGC Genetics

This panel specifically test the BCL6 gene.

More info about this panel

Detection by FISH of NHL diffuse large cells (t(14;18), t(8;14) and BCL6) Panel

Portugal.

By CGC Genetics

This panel specifically test the BCL6 gene.

More info about this panel

Cancer Hotspot Panel Panel

Germany.

By Centogene AG - the Rare Disease Company Cancer Hotspot Panel that also includes the following genes: BCL6 ROS1 BRAF BRCA1 BRCA2 SMARCB1 SMO SRC STK11 HNF1A

More info about this panel

Fluorescent in situ Hybridization - Hematopathology Panel

United States.

By Hartford Hospital Laboratory - Molecular Genetics and Cytogenetics Hartford Hospital-Hartford-CT-USA Fluorescent in situ Hybridization - Hematopathology that also includes the following genes: BCL6 BCR RUNX1 ABI1 TCF3 TP53 DLEU1 CRLF2 RUNX1T1 CBFB

More info about this panel

FISH, Lymphoma Panel Panel

United States.

By Cytogenetics and Molecular Pathology Laboratory UP Health System Marquette FISH, Lymphoma Panel that also includes the following genes: BCL6 CCND1 IGH MALT1 MYC

More info about this panel

BCL6 Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the BCL6 gene.

More info about this panel

Onco microarray for CLL Panel

United States.

By Pittsburgh Cytogenetics Laboratory University of Pittsburgh Medical Center Onco microarray for CLL that also includes the following genes: BCL6 TP53 BCL11A CCND1 FGF2 AKT1 ALK IGH ITK MYB

More info about this panel

Focus::DLBCL&FL™ NGS Panel Panel

United States.

By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::DLBCL&FL™ NGS Panel that also includes the following genes: BCL6 SGK1 BRAF ARID1A BTK STAT3 STAT6 SYK TNFAIP3 FAS

More info about this panel

Focus::Lymphoma™ NGS Panel Panel

United States.

By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::Lymphoma™ NGS Panel that also includes the following genes: BCL6 SGK1 BRAF ARID1A BTK STAT3 STAT6 SYK TNFAIP3 FAS

More info about this panel

FoundationOne® Heme Panel

United States.

By Foundation Medicine, Inc. FoundationOne® Heme that also includes the following genes: BCL6 BCL7A ROS1 RUNX1 BLM SDHA SDHB SDHC SDHD SF3B1

More info about this panel

NeoTYPE® Discovery Profile for Solid Tumors Panel

United States.

By NeoGenomics Laboratories NeoGenomics Laboratories, Inc. NeoTYPE® Discovery Profile for Solid Tumors that also includes the following genes: BCL6 ROS1 RUNX1 BLM SDHA SDHB SDHC SDHD SF3B1 FOXL2

More info about this panel

Caris MI TumorSeek 592-Gene NGS Panel Panel

United States.

By Caris Life Sciences Caris MI TumorSeek 592-Gene NGS Panel that also includes the following genes: BCL6 BCL7A BCL9 BCR ROS1 RPL10 RPL22 RPL5 RPN1 RUNX1

More info about this panel

Tempus xT assay Panel

United States.

By Tempus Labs, Inc. Tempus xT assay that also includes the following genes: BCL6 RIT1 BCL7A BCR ROS1 RPL5 RPS15 RPS6KB1 RUNX1 RXRA

More info about this panel

Tempus xO assay Panel

United States.

By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2

More info about this panel


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