BCL10 gene related symptoms and diseases

All the information presented here about the BCL10 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: HGNC,OMIM,ORPHANET,NCBIGENE, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to BCL10 gene

Symptoms // Phenotype % Cases
Neoplasm Common - Between 50% and 80% cases
Anemia Uncommon - Between 30% and 50% cases
Hodgkin lymphoma Uncommon - Between 30% and 50% cases
Lymphoma Uncommon - Between 30% and 50% cases
Immunodeficiency Uncommon - Between 30% and 50% cases

Other less frequent symptoms and clinical features

Patients with BCL10 gene alterations may also develop some of the following symptoms and phenotypes:
  • Not very common - Between 30% and 50% cases

  • B-cell lymphoma
  • Lymphadenopathy
  • Weight loss
  • Abdominal pain
  • Fever
  • Rarely - Less than 30% cases

  • Non-Hodgkin lymphoma
  • Chest pain
  • Decreased antibody level in blood

And 71 more phenotypes, you can get all of them using our tools for rare diseases.

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Rare diseases associated to BCL10 gene

Here you will find a list of rare diseases related to the BCL10. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


TESTICULAR TERATOMA


Alternate names

TESTICULAR TERATOMA Is also known as male germ cell tumor, mgct, teratoma of the testis

Description

Testicular germ cell tumors (TGCTs) affect 1 in 500 men and are the most common cancer in males aged 15 to 40 in western European populations. The incidence of TGCT rose dramatically during the 20th century. Known risk factors for TGCT include a history of undescended testis (UDT), testicular dysgenesis, infertility, previously diagnosed TGCT, and a family history of the disease. Brothers of men with TGCT have an 8- to 10-fold risk of developing TGCT, whereas the relative risk to fathers and sons is 4-fold. This familial relative risk is much higher than that for most other types of cancer (summary by Rapley et al., 2000). Genetic Heterogeneity of Testicular Germ Cell TumorsA locus for testicular germ cell tumors (TGCT1 ) has been identified on chromosome Xq27.

Most common symptoms of TESTICULAR TERATOMA

  • Neoplasm
  • Cryptorchidism
  • Hydrocephalus
  • Abnormality of metabolism/homeostasis
  • Carcinoma


More info about TESTICULAR TERATOMA

SOURCES: OMIM ORPHANET

MALT LYMPHOMA


Alternate names

MALT LYMPHOMA Is also known as maltoma, mucosa-associated lymphatic tissue lymphoma, extranodal marginal zone b-cell lymphoma, mucosa-associated lymphoid tissue lymphoma

Description

MALT (mucosa-associated lymphoid tissue) lymphoma is a rare form of malignant non-Hodgkin lymphoma (see this term) that affects B cells and grows at the expense of lymphoid tissue associated with mucous membranes, but also occurs, more rarely, in lymph nodes.

Most common symptoms of MALT LYMPHOMA

  • Anemia
  • Visual impairment
  • Fever
  • Fatigue
  • Constipation


More info about MALT LYMPHOMA

SOURCES: ORPHANET

LYMPHOMA, MUCOSA-ASSOCIATED LYMPHOID TYPE


Alternate names

LYMPHOMA, MUCOSA-ASSOCIATED LYMPHOID TYPE Is also known as malt lymphoma, gastric lymphoma, primary

Description

The concept of mucosa-associated lymphoid tissue (MALT) lymphomas was introduced by Isaacson and Wright (1983). MALT lymphomas are now recognized as a distinct subtype of non-Hodgkin lymphoma (OMIM ). B-cell lymphomas of mucosa-associated lymphoid tissue (MALT lymphomas) are the most common form of lymphoma arising in extranodal sites, in most cases arising in the gastric mucosa (Isaacson and Spencer, 1995).

Most common symptoms of LYMPHOMA, MUCOSA-ASSOCIATED LYMPHOID TYPE

  • Neoplasm
  • Immunodeficiency
  • Lymphoma
  • Hodgkin lymphoma
  • Gastric ulcer


More info about LYMPHOMA, MUCOSA-ASSOCIATED LYMPHOID TYPE

SOURCES: OMIM ORPHANET

PLEURAL MESOTHELIOMA


Description

Malignant mesothelioma is a fatal asbestos-associated malignancy arising in the lining cells (mesothelium) of the pleural and peritoneal cavities, as well as in the pericardium and the tunica vaginalis.

Most common symptoms of PLEURAL MESOTHELIOMA

  • Neoplasm
  • Pain
  • Anemia
  • Hepatomegaly
  • Fever


More info about PLEURAL MESOTHELIOMA

SOURCES: OMIM ORPHANET

NON-HODGKIN LYMPHOMA


Alternate names

NON-HODGKIN LYMPHOMA Is also known as nhl, non-hodgkin lymphoma

Description

Non-Hodgkin malignant lymphomas(NHL) is a heterogeneous group of malignant tumors of the lymphoid system.

Most common symptoms of NON-HODGKIN LYMPHOMA

  • Neoplasm
  • Leukemia
  • Lymphoma
  • Hodgkin lymphoma
  • B-cell lymphoma


More info about NON-HODGKIN LYMPHOMA

SOURCES: ORPHANET OMIM

IMMUNODEFICIENCY 37; IMD37


Most common symptoms of IMMUNODEFICIENCY 37; IMD37

  • Seizures
  • Immunodeficiency
  • Recurrent infections
  • Respiratory tract infection
  • Decreased antibody level in blood


More info about IMMUNODEFICIENCY 37; IMD37

SOURCES: OMIM


Potential gene panels for BCL10 gene

Mesothelioma, somatic Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the BCL10 gene.

More info about this panel

Lymphoma, MALT, somatic Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the BCL10 gene.

More info about this panel

Lymphoma, follicular, somatic Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the BCL10 gene.

More info about this panel

Male germ cell tumor, somatic Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the BCL10 gene.

More info about this panel

Invitae Comprehensive Severe Combined Immunodeficiency (SCID) and Combined Immunodeficiency (CID) Panel Panel

United States.

By Invitae Invitae Comprehensive Severe Combined Immunodeficiency (SCID) and Combined Immunodeficiency (CID) Panel that also includes the following genes: STK4 TAPBP TNFRSF4 CD27 CD40LG ZAP70 CARD11 CD3D CD3E CD3G

More info about this panel

Invitae Primary Immunodeficiency Panel Panel

United States.

By Invitae Invitae Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC SEMA3E SH2D1A SH3BP2 SLC7A7 SMARCAL1 BTK STAT1 STAT2

More info about this panel

Invitae Combined Immunodeficiency (CID) Panel Panel

United States.

By Invitae Invitae Combined Immunodeficiency (CID) Panel that also includes the following genes: STK4 TAPBP TNFRSF4 CD27 CD40LG ZAP70 CARD11 CD3G CD8A LRBA

More info about this panel

BCL10 Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the BCL10 gene.

More info about this panel

Onco microarray for CLL Panel

United States.

By Pittsburgh Cytogenetics Laboratory University of Pittsburgh Medical Center Onco microarray for CLL that also includes the following genes: BCL6 TP53 BCL11A CCND1 FGF2 AKT1 ALK IGH ITK MYB

More info about this panel

Primary Immunodeficiency Panel Panel

Finland.

By Blueprint Genetics Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC CFB BLM SH2D1A SLC7A7 SMARCAL1 SMARCD2 SRP72 BTK

More info about this panel

Focus::DLBCL&FL™ NGS Panel Panel

United States.

By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::DLBCL&FL™ NGS Panel that also includes the following genes: BCL6 SGK1 BRAF ARID1A BTK STAT3 STAT6 SYK TNFAIP3 FAS

More info about this panel

Focus::Lymphoma™ NGS Panel Panel

United States.

By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::Lymphoma™ NGS Panel that also includes the following genes: BCL6 SGK1 BRAF ARID1A BTK STAT3 STAT6 SYK TNFAIP3 FAS

More info about this panel

FoundationOne® Heme Panel

United States.

By Foundation Medicine, Inc. FoundationOne® Heme that also includes the following genes: BCL6 BCL7A ROS1 RUNX1 BLM SDHA SDHB SDHC SDHD SF3B1

More info about this panel

Caris MI TumorSeek 592-Gene NGS Panel Panel

United States.

By Caris Life Sciences Caris MI TumorSeek 592-Gene NGS Panel that also includes the following genes: BCL6 BCL7A BCL9 BCR ROS1 RPL10 RPL22 RPL5 RPN1 RUNX1

More info about this panel

Tempus xT assay Panel

United States.

By Tempus Labs, Inc. Tempus xT assay that also includes the following genes: BCL6 RIT1 BCL7A BCR ROS1 RPL5 RPS15 RPS6KB1 RUNX1 RXRA

More info about this panel

Tempus xO assay Panel

United States.

By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2

More info about this panel


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