Vogt-koyanagi-harada Disease

Description

Vogt-Koyanagi-Harada disease is a bilateral, chronic, diffuse granulomatous panuveitis typically characterized by serous retinal detachment and frequently associated with neurological (meningitis), auditory, and dermatological alterations.

Clinical Features

Top most frequent phenotypes and symptoms related to Vogt-koyanagi-harada Disease

  • Short stature
  • Sensorineural hearing impairment
  • Cataract
  • Cognitive impairment
  • Visual impairment
  • Glaucoma
  • Retinal detachment
  • Sparse scalp hair
  • Hypopigmented skin patches
  • Premature graying of hair

And another 4 symptoms. If you need more information about this disease we can help you.

Click here to know more about Mendelian.

Incidence and onset information

Not enough data available about incidence and published cases.
No data available about the known clinical features onset.

Alternative names

Vogt-koyanagi-harada Disease Is also known as uveomenigitic syndrome.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.


Mendelian

Accelerate your rare disease diagnosis with us

Learn more

Vogt-koyanagi-harada Disease Recommended genes panels

Panel Name, Specifity and genes Tested/covered
FAS Sequencing.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center (United States).

FAS
Specificity
100 %
Genes
25 %
Autoimmune Lymphoproliferative Syndrome Panel by next-generation sequencing (NGS).

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center (United States).

FAS, FASLG, CASP10, CASP8, MAGT1, FADD, ITK, KRAS, NRAS
Specificity
12 %
Genes
25 %
Autoimmune Lymphoproliferative Syndrome Deletion/Duplication Panel.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center (United States).

FAS, FASLG, CASP10, CASP8, MAGT1, FADD, ITK, KRAS, NRAS
Specificity
12 %
Genes
25 %
FAS Deletion/duplication analysis.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center (United States).

FAS
Specificity
100 %
Genes
25 %
Tier 2: Hereditary Lymphoma and Immunodeficiency Panel.

By Genetic Services Laboratory University of Chicago (United States).

BLM, SH2D1A, BRCA1, BRCA2, STXBP2, FAS, CD27, FASLG, WAS, IKZF1, CASP10, CARD11, TNFRSF13B, ADA, DOCK8, CTLA4, MAGT1, ITK, NBN, NF1 , (...)

View the complete list with 3 more genes
Specificity
5 %
Genes
25 %
FAS (TNFRSF6) Gene Sequencing.

By GeneDx (United States).

FAS
Specificity
100 %
Genes
25 %
FAS. Complete sequencing.

By Instituto de Medicina Genomica Instituto de Medicina Genomica (Spain).

FAS
Specificity
100 %
Genes
25 %
Autoimmune lymphoproliferative syndrome (sequence analysis of FAS gene).

By CGC Genetics (Portugal).

FAS
Specificity
100 %
Genes
25 %

We have 36 more panels available in our App

Get the app

Sources and references

You can check the following sources for additional information.

ORPHANET MESH Rare Disease Search Engine

If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like OSTEOGENESIS IMPERFECTA, TYPE XV; OI15

Need help with a diagnosis?

Learn more about how to achieve it with Mendelian


Learn more