Usher Syndrome, Type Iia; Ush2a

Description

Usher syndrome is a clinically and genetically heterogeneous autosomal recessive disorder characterized by sensorineural hearing deficiencies at birth and later development of progressive retinitis pigmentosa (RP). It is the most frequent cause of combined deafness and blindness in adults and affects 3 to 6% of children born with hearing impairment. In brief, patients with Usher syndrome type II have mild hearing impairment with normal vestibular responses. Type II is the most common of the 3 Usher syndromes (Eudy et al., 1998). See {276900} for clinical characterization of Usher syndrome types I, II, and III. Genetic Heterogeneity of Usher Syndrome Type IIUsher syndrome type II is genetically heterogeneous. USH2C (OMIM ) can be caused by mutation in the ADGRV1 gene (OMIM ) or by biallelic digenic mutation in the ADGRV1 and PDZD7 (OMIM ) genes. USH2D (OMIM ) is caused by mutation in the WHRN gene (OMIM ).The locus designation USH2B has been withdrawn; see HISTORY.

Clinical Features

Top most frequent phenotypes and symptoms related to Usher Syndrome, Type Iia; Ush2a

  • Hearing impairment
  • Sensorineural hearing impairment
  • Blindness
  • Depressivity
  • Rod-cone dystrophy
  • Retinopathy
  • Nyctalopia
  • Lymphoma
  • Pigmentary retinopathy
  • Bilateral sensorineural hearing impairment

And another 7 symptoms. If you need more information about this disease we can help you.

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Incidence and onset information

— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)
No data available about the known clinical features onset.

Researches and researchers

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Usher Syndrome, Type Iia; Ush2a Recommended genes panels

Panel Name, Specifity and genes Tested/covered
MitoMetĀ®Plus aCGH Analysis.

By Baylor Miraca Genetics Laboratories (United States).

RGS9, RHO, GRK1, RLBP1, RNASEL, BCS1L, RP1, RP2, RP9, RPE65, RPGR, RPL35A, MRPL3, RPS14, RS1, SAG, SARDH, SCO2, SCP2, SDHB , (...)

View the complete list with 612 more genes
Specificity
1 %
Genes
100 %
DFNB31 Comprehensive - Sequence & Deletion/Duplication Analysis.

By Baylor Miraca Genetics Laboratories (United States).

WHRN
Specificity
100 %
Genes
34 %
DFNB31 Deletion/Duplication Analysis.

By Baylor Miraca Genetics Laboratories (United States).

WHRN
Specificity
100 %
Genes
34 %
DFNB31 Sequence Analysis.

By Baylor Miraca Genetics Laboratories (United States).

WHRN
Specificity
100 %
Genes
34 %
DFNB31 Sequence Analysis (Prenatal Diagnosis).

By Baylor Miraca Genetics Laboratories (United States).

WHRN
Specificity
100 %
Genes
34 %
Hearing Loss Advanced Sequencing and CNV Evaluation.

By Athena Diagnostics Inc (United States).

BCS1L, ROR1, SALL1, SEMA3E, SIX1, SIX5, SLC12A1, SLC19A2, SLC22A4, SNAI2, SMPX, SOX10, TBX1, TCOF1, TECTA, TFAP2A, TIMM8A, TJP2, TMPRSS3, USH1C , (...)

View the complete list with 149 more genes
Specificity
2 %
Genes
100 %
NGS Hearing Loss Panel.

By Greenwood Genetic Center Diagnostic Laboratories Greenwood Genetic Center (United States).

SIX1, SNAI2, SMPX, SOX10, TECTA, TIMM8A, TJP2, TMPRSS3, USH1C, USH2A, CLRN1, TSPEAR, WFS1, ESPN, CDH23, CACNA1D, ACTG1, PCDH15, USH1G, WHRN , (...)

View the complete list with 70 more genes
Specificity
3 %
Genes
67 %
OtoSCOPE.

By Molecular Otolaryngology and Renal Research Laboratories University of Iowa Hospital and Clinics (United States).

ROR1, SIX1, SIX5, SLC22A4, SNAI2, SMPX, SOX10, TBX1, TWNK, TCOF1, TECTA, TIMM8A, TJP2, TMPRSS3, USH1C, USH2A, CLRN1, TSPEAR, WFS1, ESPN , (...)

View the complete list with 130 more genes
Specificity
2 %
Genes
100 %

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Sources and references

You can check the following sources for additional information.

OMIM Rare Disease Search Engine

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