Tropical Calcific Pancreatitis

Description

Tropical pancreatitis is a rare pancreatic disease of juvenile onset occurring mainly in tropical developing countries and characterized by chronic non-alcoholic pancreatitis manifesting with abdominal pain, steatorrhea and fibrocalculous pancreatopathy (see this term). It is also commonly associated with the development of pancreatic calculi and pancreatic cancer at a much higher frequency than seen in ordinary chronic pancreatitis.

Clinical Features

Phenotypes and symptoms related to Tropical Calcific Pancreatitis

  • Pica
  • Neoplasm
  • Diabetes mellitus
  • Abdominal pain
  • Pancreatitis
  • Ketosis
  • Neoplasm of the pancreas
  • Chronic pancreatitis
  • Pancreatic calcification
  • Insulin-dependent but ketosis-resistant diabetes

Incidence and onset information

Not enough data available about incidence and published cases.


Mendelian

Accelerate your rare disease diagnosis with us

Learn more

Tropical Calcific Pancreatitis Recommended genes panels

Panel Name, Specifity and genes Tested/covered
Hereditary pancreatitis.

By Center for Human Genetics, Inc in United States.

SPINK1, PRSS1, CTRC
Specificity
67 %
Genes
100 %
Hereditary pancreatitis.

By Center for Human Genetics, Inc in United States.

CFTR, SPINK1, PRSS1, CTRC
Specificity
50 %
Genes
100 %
Pancreas Panel.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center in United States.

CFTR, SBDS, CEL, CASR, SPINK1, PRSS1, CTRC, CPA1, CLDN2, UBR1
Specificity
20 %
Genes
100 %
Pancreas Panel Deletion/duplication Analysis.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center in United States.

CFTR, CASR, SPINK1, CTRC
Specificity
50 %
Genes
100 %
Pancreatitis (CTRC) Sequencing.

By ARUP Laboratories, Molecular Genetics and Genomics in United States.

CTRC
Specificity
100 %
Genes
50 %
Pancreatitis, Panel (CTRC, CFTR, PRSS1, SPINK1) Sequencing.

By ARUP Laboratories, Molecular Genetics and Genomics in United States.

CFTR, SPINK1, PRSS1, CTRC
Specificity
50 %
Genes
100 %
Pancreatitis Panel.

By Ambry Genetics in United States.

CFTR, SPINK1, PRSS1, CTRC
Specificity
50 %
Genes
100 %
CTRC. Complete sequencing.

By Instituto de Medicina Genomica Instituto de Medicina Genomica in Spain.

CTRC
Specificity
100 %
Genes
50 %
CTRC. Detection of the mutations p.Arg254Trp and p.Lys247_Arg254del by sequencing.

By Instituto de Medicina Genomica Instituto de Medicina Genomica in Spain.

CTRC
Specificity
100 %
Genes
50 %
Pancreatitis Del/Dup Panel.

By Division of Genomic Diagnostics The Children's Hospital of Philadelphia in United States.

CFTR, CASR, SPINK1, CTRC
Specificity
50 %
Genes
100 %
Pancreatitis Seq Analysis.

By Division of Genomic Diagnostics The Children's Hospital of Philadelphia in United States.

CFTR, CASR, SPINK1, PRSS1, CTRC
Specificity
40 %
Genes
100 %
Pancreatitis Seq + Del/Dup Panel.

By Division of Genomic Diagnostics The Children's Hospital of Philadelphia in United States.

CFTR, CASR, SPINK1, PRSS1, CTRC
Specificity
40 %
Genes
100 %
Pancreatitis, chronic (sequence analysis of CTRC gene).

By CGC Genetics in Portugal.

CTRC
Specificity
100 %
Genes
50 %
Chronic Pancreatitis via Chymotrypsin C (CTRC) Gene Sequencing with CNV Detection.

By PreventionGenetics PreventionGenetics in United States.

CTRC
Specificity
100 %
Genes
50 %
Chronic Pancreatitis Sequencing Panel with CNV Detection.

By PreventionGenetics PreventionGenetics in United States.

CFTR, CASR, SPINK1, PRSS1, CTRC
Specificity
40 %
Genes
100 %
CTRC.

By Department of Clinical Genetics Odense University Hospital in Denmark.

CTRC
Specificity
100 %
Genes
50 %
CTRC.

By MGZ Medical Genetics Center in Germany.

CTRC
Specificity
100 %
Genes
50 %
Pancreatitis hereditary CTRC related.

By Centogene AG - the Rare Disease Company in Germany.

CTRC
Specificity
100 %
Genes
50 %
Single gene testing CTRC.

By CeGaT GmbH in Germany.

CTRC
Specificity
100 %
Genes
50 %
Invitae Chronic Pancreatitis Panel.

By Invitae in United States.

CFTR, CASR, SPINK1, PRSS1, CTRC
Specificity
40 %
Genes
100 %
Pancreatitis, chronic, susceptibility to:CTRC gene sequence analysis.

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases in Spain.

CTRC
Specificity
100 %
Genes
50 %
HEREDITARY PANCREATITIS.

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases in Spain.

CFTR, CASR, SPINK1, PRSS1, CTRC
Specificity
40 %
Genes
100 %
Chronic Pancreatitis NGS Panel.

By Fulgent Genetics Fulgent Genetics in United States.

CFTR, CASR, SPINK1, PRSS1, CTRC
Specificity
40 %
Genes
100 %
CTRC.

By Fulgent Genetics Fulgent Genetics in United States.

CTRC
Specificity
100 %
Genes
50 %
Pancreatitis Panel.

By Blueprint Genetics in Finland.

CFTR, SPINK1, PRSS1, CTRC, APOA5, APOC2, GPIHBP1, CPA1, UBR1
Specificity
23 %
Genes
100 %
Hereditary chronic pancreatitis.

By Bioarray in Spain.

CTRC
Specificity
100 %
Genes
50 %
CHRONIC PANCREATITIS.

By Laboratorio de Genetica Clinica SL in Spain.

CFTR, SPINK1, PRSS1, CTRC
Specificity
50 %
Genes
100 %
CHRONIC PANCREATITIS: NGS PANEL.

By Laboratorio de Genetica Clinica SL in Spain.

CFTR, SPINK1, PRSS1, CTRC
Specificity
50 %
Genes
100 %
Hereditary Chronic Pancreatitis , Sequencing CTRC Gene.

By Reference Laboratory Genetics in Spain.

CTRC
Specificity
100 %
Genes
50 %
Hereditary Pancreatitis , Panel Massive Sequencing (NGS) 5 Genes.

By Reference Laboratory Genetics in Spain.

CFTR, SPINK1, PRSS1, CTRC, PRSS2
Specificity
40 %
Genes
100 %
Hereditary pancreatitis.

By Labor Dr. Wisplinghoff in Germany.

CFTR, SPINK1, PRSS1, CTRC
Specificity
50 %
Genes
100 %
Phosphorus Pancreatic Cancer including Chronic Pancreatitis Genes Panel.

By Phosphorus Diagnostics LLC in United States.

BRCA1, BRCA2, VHL, APC, EPCAM, MSH2, PMS2, MSH6, MLH1, TP53, MEN1, CFTR, TSC2, TSC1, ATM, PALB2, STK11, CDKN2A, BMPR1A, SMAD4 , (...)

View the complete list with 5 more genes
Specificity
8 %
Genes
100 %
Tempus xT assay.

By Tempus Labs, Inc. in United States.

BRCA1, BRCA2, MTHFR, VHL, APC, EPCAM, MSH2, PMS2, MSH6, MLH1, MUTYH, PTEN, RECQL4, RUNX1, TP53, ATP7B, FOXL2, HNF1A, WT1, RB1 , (...)

View the complete list with 571 more genes
Specificity
1 %
Genes
100 %
Pancreatitis: gene sequencing panel.

By CEN4GEN Institute for Genomics and Molecular Diagnostics in Canada.

CFTR, SPINK1, PRSS1, CTRC
Specificity
50 %
Genes
100 %
SPINK1-Related Hereditary Pancreatitis.

By Center for Human Genetics, Inc in United States.

SPINK1
Specificity
100 %
Genes
50 %
Hereditary pancreatitis.

By Center for Human Genetics, Inc in United States.

SPINK1, PRSS1
Specificity
50 %
Genes
50 %
Pancreatitis: SPINK1 (Full Gene Sequencing).

By Molecular Diagnostic Laboratory LabCorp in United States.

SPINK1
Specificity
100 %
Genes
50 %
Pancreatitis: SPINK1 (Known Mutation).

By Molecular Diagnostic Laboratory LabCorp in United States.

SPINK1
Specificity
100 %
Genes
50 %
Pancreatitis: Three-gene Profile (PRSS1, SPINK1, CFTR) (Full Gene Sequencing).

By Molecular Diagnostic Laboratory LabCorp in United States.

CFTR, SPINK1, PRSS1
Specificity
34 %
Genes
50 %
Pancreatitis (SPINK1) Sequencing.

By ARUP Laboratories, Molecular Genetics and Genomics in United States.

SPINK1
Specificity
100 %
Genes
50 %
SPINK1. Complete sequencing.

By Instituto de Medicina Genomica Instituto de Medicina Genomica in Spain.

SPINK1
Specificity
100 %
Genes
50 %
SPINK1. Sequencing of the exon 3.

By Instituto de Medicina Genomica Instituto de Medicina Genomica in Spain.

SPINK1
Specificity
100 %
Genes
50 %
Pancreatitis, hereditary (sequence analysis of SPINK1 gene).

By CGC Genetics in Portugal.

SPINK1
Specificity
100 %
Genes
50 %
Pancreatitis, hereditary (deletion/duplication analysis of PRSS1 and SPINK genes).

By CGC Genetics in Portugal.

SPINK1, PRSS1
Specificity
50 %
Genes
50 %
Pancreatitis, chronic (N34S mutation on SPINK gene and R122H and N29I mutations on PRSS1 gene).

By CGC Genetics in Portugal.

SPINK1, PRSS1
Specificity
50 %
Genes
50 %
Pancreatitis, hereditary (sequence analysis of SPINK1 and PRSS1 genes).

By CGC Genetics in Portugal.

SPINK1, PRSS1
Specificity
50 %
Genes
50 %
SPINK1 related Hereditary Pancreatitis.

By Mersey Regional Genetics Laboratories Liverpool Women's Hospital in United Kingdom.

SPINK1
Specificity
100 %
Genes
50 %
SPINK1-Related Hereditary Pancreatitis.

By Laboratory of Gastroenterology and Hepatology Radboud university medical center in Netherlands.

SPINK1
Specificity
100 %
Genes
50 %
Chronic Hereditary Pancreatitis via SPINK1 Gene Sequencing with CNV Detection.

By PreventionGenetics PreventionGenetics in United States.

SPINK1
Specificity
100 %
Genes
50 %
SPINK1.

By Department of Clinical Genetics Odense University Hospital in Denmark.

SPINK1
Specificity
100 %
Genes
50 %
SPINK1-Related Hereditary Pancreatitis.

By MGZ Medical Genetics Center in Germany.

SPINK1
Specificity
100 %
Genes
50 %
SPINK1-Related Hereditary Pancreatitis.

By Bioscientia GmbH Center for Human Genetics in Germany.

SPINK1
Specificity
100 %
Genes
50 %
Hereditary Pancretitis.

By Synlab MVZ Humane Genetik München Synlab MVZ Humane Genetik München in Germany.

SPINK1, PRSS1
Specificity
50 %
Genes
50 %
Hereditary pancreatitis.

By DNA Diagnostics Laboratory University Hospital Ostrava in Czech Republic.

CFTR, SPINK1, PRSS1
Specificity
34 %
Genes
50 %
CentoICU platinum plus.

By Centogene AG - the Rare Disease Company in Germany.

BRCA2, F2, F5, MTHFR, UBE3A, MCCC1, MCCC2, AARS2, ACAD9, ACADL, ACADM, ACADS, AGL, ACADVL, ACAT1, ALDOA, ALDOB, FBP1, PC, GYS2 , (...)

View the complete list with 494 more genes
Specificity
1 %
Genes
50 %
CentoICU platinum.

By Centogene AG - the Rare Disease Company in Germany.

BRCA2, F2, F5, MTHFR, UBE3A, MCCC1, MCCC2, AARS2, ACAD9, ACADL, ACADM, ACADS, AGL, ACADVL, ACAT1, ALDOA, ALDOB, FBP1, PC, GYS2 , (...)

View the complete list with 494 more genes
Specificity
1 %
Genes
50 %
Pancreatitis hereditary SPINK1 related.

By Centogene AG - the Rare Disease Company in Germany.

SPINK1
Specificity
100 %
Genes
50 %
Hereditary Pancreatitis.

By bio.logis Center for Human Genetics Diagnosticum in Germany.

CFTR, SPINK1, PRSS1
Specificity
34 %
Genes
50 %
Pancreatic cancer Panel.

By CeGaT GmbH in Germany.

BRCA1, BRCA2, VHL, APC, EPCAM, MSH2, PMS2, MSH6, MLH1, TP53, ATM, PALB2, STK11, CDKN2A, SPINK1, PRSS1, PALLD
Specificity
6 %
Genes
50 %
Single gene testing SPINK1.

By CeGaT GmbH in Germany.

SPINK1
Specificity
100 %
Genes
50 %
Chronic Pancreatitis.

By Molecular Diagnostics Division Centre for Cellular and Molecular Biology in India.

SPINK1
Specificity
100 %
Genes
50 %
Hereditary pancreatitis (SPINK1, PRSS1).

By Center for Human Genetics Cliniques Universitaires Saint Luc in Belgium.

SPINK1, PRSS1
Specificity
50 %
Genes
50 %
Pancreatitis.

By Praxis fuer Humangenetik Wien in Austria.

SPINK1
Specificity
100 %
Genes
50 %
Hereditary pancreatitis.

By Department of Clinical Genetics St. Elisabeth Cancer Institute in Slovakia.

SPINK1, PRSS1
Specificity
50 %
Genes
50 %
Pancreatitis.

By MedGene in Slovakia.

SPINK1
Specificity
100 %
Genes
50 %
Chronic pancreatitis: SPINK1 mutation analysis gene (N34S).

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases in Spain.

SPINK1
Specificity
100 %
Genes
50 %
Chronic pancreatitis: SPINK1 gene sequence analysis.

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases in Spain.

SPINK1
Specificity
100 %
Genes
50 %
SPINK1.

By Fulgent Genetics Fulgent Genetics in United States.

SPINK1
Specificity
100 %
Genes
50 %
Hereditary chronic pancreatitis.

By Bioarray in Spain.

SPINK1
Specificity
100 %
Genes
50 %
Mutation Analysis of common mutations for hereditary pancreatitis.

By Diagnostics Division Centre for DNA Fingerprinting and Diagnostics in India.

SPINK1, PRSS1
Specificity
50 %
Genes
50 %
Hereditary Chronic Pancreatitis , Sequencing SPINK1 Gene.

By Reference Laboratory Genetics in Spain.

SPINK1
Specificity
100 %
Genes
50 %
Hereditary Chronic Pancreatitis , Mutation (N34S) SPINK1 Gene.

By Reference Laboratory Genetics in Spain.

SPINK1
Specificity
100 %
Genes
50 %

Alternate names

Tropical Calcific Pancreatitis Is also known as tcp;tcp; tropical calcific chronic pancreatitis.



If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like STANKIEWICZ-ISIDOR SYNDROME; STISS PEHO SYNDROME; PEHO FRUCTOSURIA, ESSENTIAL CHARCOT-MARIE-TOOTH DISEASE, TYPE 4D; CMT4D GERODERMA OSTEODYSPLASTICUM; GO PANCREATIC CANCER, SUSCEPTIBILITY TO, 2

Need help with a diagnosis?

Learn more about how to achieve it with Mendelian


Learn more