Thyroid Carcinoma, Familial Medullary; Mtc
Description
Medullary thyroid carcinoma (MTC) is a malignant tumor of the calcitonin (OMIM )-secreting parafollicular C cells of the thyroid, and occurs sporadically or as a component of the multiple endocrine neoplasia (MEN) type 2 (see {171400})/familial medullary thyroid carcinoma (FMTC) syndromes (summary by Abu-Amero et al., 2006). Thyroid cancer derived from follicular epithelial cells is referred to as nonmedullary thyroid cancer and comprises several subtypes; see {188550}.
Clinical Features
Top most frequent phenotypes and symptoms related to Thyroid Carcinoma, Familial Medullary; Mtc
- Neoplasm
- Pain
- Respiratory distress
- Hypothyroidism
- Carcinoma
- Lymphadenopathy
- Lymphoma
- Aganglionic megacolon
- Hoarse voice
- Goiter
And another 10 symptoms. If you need more information about this disease we can help you.
Incidence and onset information
— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)— No data available about the known clinical features onset.
Alternative names
Thyroid Carcinoma, Familial Medullary; Mtc Is also known as mtc1, fmtc.
Researches and researchers
Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.Thyroid Carcinoma, Familial Medullary; Mtc Recommended genes panels
Panel Name, Specifity and genes Tested/covered |
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WNK1, NTRK1
Specificity
50 %
Genes
50 % |
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NTRK1
Specificity
100 %
Genes
50 % |
![]() By ARUP Laboratories, Molecular Genetics and Genomics (United States).
SBF1, SCN9A, SLC12A6, SOX10, ATL1, SPTLC1, SPTLC2, TFG, YARS, PRX, SLC5A7, ARHGEF10, WNK1, BSCL2, GDAP1, TRIM2, CCT5, KIF1B, LITAF, FIG4 , (...)
View the complete list with 58 more genes
Specificity
2 %
Genes
50 % |
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SBF1, SCN9A, SLC12A6, SOX10, ATL1, SPTLC1, SPTLC2, TFG, YARS, PRX, SLC5A7, ARHGEF10, WNK1, BSCL2, GDAP1, TRIM2, CCT5, KIF1B, LITAF, FIG4 , (...)
View the complete list with 58 more genes
Specificity
2 %
Genes
50 % |
![]() By GeneDx (United States).
NTRK1
Specificity
100 %
Genes
50 % |
![]() By Instituto de Medicina Genomica Instituto de Medicina Genomica (Spain).
NTRK1
Specificity
100 %
Genes
50 % |
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NTRK1
Specificity
100 %
Genes
50 % |
![]() By CGC Genetics (Portugal).
SBF1, SCN11A, SCN9A, DST, SLC12A6, SOX10, ATL1, SPTLC1, SPTLC2, TWNK, TFG, TTR, YARS, PRX, ARHGEF10, WNK1, BSCL2, ABHD12, GDAP1, TRIM2 , (...)
View the complete list with 54 more genes
Specificity
2 %
Genes
50 % |
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Learn moreSources and references
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