Spermatogenic Failure, Y-linked, 2; Spgfy2

Description

About 2 to 3% of human males are infertile because of defects in sperm function, primarily due to oligozoospermia (defined as less than 10-15 million sperm per mL of semen) or azoospermia (Hull et al., 1985). Heterogeneity of Spermatogenic FailureFor a discussion of Y-linked spermatogenic failure due to Sertoli cell-only syndrome, see {400042}.For a discussion of phenotypic and genetic heterogeneity of spermatogenic failure, see SPGF1 (OMIM ).

Clinical Features

Phenotypes and symptoms related to Spermatogenic Failure, Y-linked, 2; Spgfy2

  • Hypogonadism
  • Infertility
  • Azoospermia
  • Male infertility
  • Abnormal sperm morphology

Incidence and onset information

— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)
No data available about the known clinical features onset.

Alternative names

Spermatogenic Failure, Y-linked, 2; Spgfy2 Is also known as oligozoospermia, nonobstructive, y-linked, spermatogenic arrest, y-linked, azoospermia, nonobstructive, y-linked, spermatogenic failure, nonobstructive, y-linked, oligospermia, nonobstructive, y-linked.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.

Spermatogenic Failure, Y-linked, 2; Spgfy2 Recommended genes panels

Panel Name, Specifity and genes Tested/covered
Spermatogenic Failure , Panel Massive Sequencing (NGS) 9 Genes.

By Reference Laboratory Genetics (Spain).

AURKC, USP9Y, CATSPER1, SYCP3, KLHL10, DPY19L2, SEPT12, SPATA16, NR5A1
Specificity
12 %
Genes
100 %
Phosphorus Male Infertility Panel.

By Phosphorus Diagnostics LLC (United States).

SRY, AURKC, USP9Y, CATSPER1, CFTR, DPY19L2, FSHB, FSHR, AR, LHCGR
Specificity
10 %
Genes
100 %
Tempus xO assay.

By Tempus Labs, Inc. (United States).

BCL6, RHEB, RIPK1, RIPK2, RIPK3, RIT1, BCL7A, BCL9, BCR, ROBO2, ROCK1, ROCK2, ROR1, ROR2, ROS1, RPA1, BDNF, RPL5, RPN1, RPS6KB1 , (...)

View the complete list with 1627 more genes
Specificity
1 %
Genes
100 %

You can get up to -5 more panels with our dedicated tool

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Sources and references

You can check the following sources for additional information.

OMIM MESH Rare Disease Symptoms Checker

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