Schizophrenia; Sczd

Description

Schizophrenia is a psychosis, a disorder of thought and sense of self. Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. There is no characteristic pathology, such as neurofibrillary tangles in Alzheimer disease (OMIM ). Schizophrenia is a common disorder with a lifetime prevalence of approximately 1%. It is highly heritable but the genetics are complex. This may not be a single entity.Schizophrenia and bipolar disorder (see {125480}) are generally considered to be separate entities, but patients who exhibit multiple symptoms of both disorders are often given the hybrid diagnosis schizoaffective disorder (Blacker and Tsuang, 1992). Genetic Heterogeneity of Schizophrenia with or without an Affective DisorderSCZD4 (OMIM ) is associated with variation in the PRODH gene (OMIM ); SCZD9 (OMIM ) with variation in the DISC1 gene (OMIM ); SCZD15 (OMIM ) with variation in the SHANK3 gene (OMIM ); SCZD16 (OMIM ) with a chromosome duplication involving the VIPR2 gene (OMIM ); SCZD17 (see {614332}) with variation in the NRXN1 gene (OMIM ); SCZD18 (OMIM ) with variation in the SLC1A1 gene (OMIM ); and SCZD19 (OMIM ) with variation in the RBM12 gene (OMIM ).For associations pending confirmation, see MAPPING and MOLECULAR GENETICS.

Clinical Features

Top most frequent phenotypes and symptoms related to Schizophrenia; Sczd

  • Intellectual disability
  • Microcephaly
  • Behavioral abnormality
  • Depressivity
  • Dementia
  • Autism
  • EEG abnormality
  • Rigidity
  • Anxiety
  • Small for gestational age

And another 20 symptoms. If you need more information about this disease we can help you.

Click here to know more about Mendelian.

Incidence and onset information

Not enough data available about incidence and published cases.
No data available about the known clinical features onset.

Alternative names

Schizophrenia; Sczd Is also known as schizophrenia with or without an affective disorder.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.


Mendelian

Accelerate your rare disease diagnosis with us

Learn more

Schizophrenia; Sczd Recommended genes panels

Panel Name, Specifity and genes Tested/covered
Serotonin Metabolism Deficiency NGS Panel.

By Fulgent Genetics Fulgent Genetics (United States).

SLC6A4, TPH1, AANAT, TPH2, HTR3C, HTR3E, DDC, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR3A, HTR3B, HTR5A, HTR6, HTR7
Specificity
6 %
Genes
10 %
HTR2A.

By Fulgent Genetics Fulgent Genetics (United States).

HTR2A
Specificity
100 %
Genes
10 %
HTR2A.

By Genelex (United States).

HTR2A
Specificity
100 %
Genes
10 %
YouScript Psychotropic.

By Genelex (United States).

SLC6A4, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, HTR2A
Specificity
15 %
Genes
10 %
GeneSight Psychotropic.

By Assurex Health, Inc. (United States).

SLC6A4, UGT1A4, UGT2B15, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, HLA-A, HTR2A
Specificity
10 %
Genes
10 %
Comprehensive Pharmacogenomics (PGX) Panel.

By ApolloGen, Inc. (United States).

SLCO1B1, VKORC1, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, F5, HTR2A, MTHFR, OPRM1
Specificity
19 %
Genes
19 %
OneOme RightMed comprehensive test.

By OneOme (United States).

SLCO1B1, SLC6A4, TPMT, UGT1A1, IFNL3, NUDT15, VKORC1, CYP2B6, CYP2C18, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, CYP4F2, DPYD, DRD2, F2, F5, GRIK4 , (...)

View the complete list with 4 more genes
Specificity
5 %
Genes
10 %
Citalopram response.

By Xcode Life Xcode Life (India).

SLC6A4, CYP2C19, HTR2A
Specificity
34 %
Genes
10 %

We have 207 more panels available in our App

Get the app

Sources and references

You can check the following sources for additional information.

OMIM Rare Disease Symptoms Checker

If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like PERRAULT SYNDROME 4; PRLTS4

Need help with a diagnosis?

Learn more about how to achieve it with Mendelian


Learn more