Salivary Gland Adenoma, Pleomorphic

Description

A benign, slow-growing tumor composed of cells that demonstrate both epithelial and mesenchymal differentiation. It is the most common neoplasm of salivary gland origin, and mostly occurs in the parotid gland. The average age of patients has been reported to be 43 years; women are more often affected than men. The malignant change rate has been estimated to be 6%. The malignant counterpart is carcinoma ex pleomorphic adenoma.

Clinical Features

Phenotypes and symptoms related to Salivary Gland Adenoma, Pleomorphic

  • Salivary gland neoplasm

Incidence and onset information

— Based on the latest data available Salivary Gland Adenoma, Pleomorphic have a estimated incidence of 2.725 per 100k in Europe.


Mendelian

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Salivary Gland Adenoma, Pleomorphic Recommended genes panels

Panel Name, Specifity and genes Tested/covered
PLAG1.

By Fulgent Genetics Fulgent Genetics in United States.

PLAG1
Specificity
100 %
Genes
50 %
Caris MI TumorSeek 592-Gene NGS Panel.

By Caris Life Sciences in United States.

BRCA1, BRCA2, VHL, APC, MSH2, PMS2, MSH6, MLH1, MUTYH, PTEN, RECQL4, RUNX1, TP53, FOXL2, HNF1A, PPARG, COL1A1, WT1, RB1, SDHAF2 , (...)

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Specificity
1 %
Genes
100 %
Tempus xO assay.

By Tempus Labs, Inc. in United States.

BRCA1, BRCA2, VHL, APC, EPCAM, MSH2, PMS2, MSH6, MLH1, MUTYH, PTEN, RECQL4, RUNX1, TP53, ABCB11, ABCB4, FKBP10, FOXL2, HNF1A, PPARG , (...)

View the complete list with 1693 more genes
Specificity
1 %
Genes
100 %
HMGA2.

By Fulgent Genetics Fulgent Genetics in United States.

HMGA2
Specificity
100 %
Genes
50 %
Uterine Leiomyoma (Somatic Mutations) , Sequencing HMGA2 Gene.

By Reference Laboratory Genetics in Spain.

HMGA2
Specificity
100 %
Genes
50 %

Alternate names

Salivary Gland Adenoma, Pleomorphic Is also known as sgpa, psa;.


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