Precocious Puberty, Male-limited

Description

Familial male limited precocious puberty (FMPP) is a gonadotropin-independent familial form of male-limited precocious puberty, generally presenting between 2-5 years of age as accelerated growth, early development of secondary sexual characteristics and reduced adult height.

Clinical Features

Top most frequent phenotypes and symptoms related to Precocious Puberty, Male-limited

  • Milia
  • Tics
  • Behavioral abnormality
  • Attention deficit hyperactivity disorder
  • Decreased testicular size
  • Tall stature
  • Abnormality of the hair
  • Accelerated skeletal maturation
  • Precocious puberty
  • Acne
And another 6 symptoms. If you need more information about this disease we can help you.
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Incidence and onset information

Not enough data available about incidence and published cases.


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Precocious Puberty, Male-limited Recommended genes panels

Panel Name, Specifity and genes Tested/covered
STON1-GTF2A1L.

By Fulgent Genetics Fulgent Genetics in United States.

STON1-GTF2A1L
Specificity
100 %
Genes
50 %
Male Precocious Puberty (LHCGR) DNA Sequencing Test.

By Athena Diagnostics Inc in United States.

LHCGR
Specificity
100 %
Genes
50 %
Male-Limited Precocious Puberty.

By Clinical Molecular Genetics Laboratory Johns Hopkins All Children's Hospital in United States.

LHCGR
Specificity
100 %
Genes
50 %
Abnormal/Ambiguous Genitalia Sequencing Panel.

By Genetic Services Laboratory University of Chicago in United States.

STAR, WT1, MKKS, CYP11B1, HSD3B2, CYP11A1, HCCS, BCOR, CYB5A, MKS1, CYP17A1, AR, ARX, CHD7, CREBBP, DHCR7, PTPN11, SRY, CDKN1C, FIG4 , (...)

View the complete list with 52 more genes
Specificity
2 %
Genes
50 %
46,XY Disorders of Sex Development/Complete Gonadal Dysgenesis Sequencing Panel.

By Genetic Services Laboratory University of Chicago in United States.

WT1, CYP11A1, HCCS, CYB5A, CYP17A1, AR, ARX, DHCR7, SRY, LHCGR, ATRX, OPHN1, SOX9, NR5A1, HSD17B3, SRD5A2, GATA4, B3GLCT, AKR1C2, DYNC2H1 , (...)

View the complete list with 6 more genes
Specificity
4 %
Genes
50 %
46,XY Disorders of Sex Development/Complete Gonadal Dysgenesis Deletion/Duplication Panel.

By Genetic Services Laboratory University of Chicago in United States.

WT1, CYP11A1, HCCS, CYB5A, CYP17A1, AR, ARX, DHCR7, SRY, LHCGR, ATRX, OPHN1, SOX9, NR5A1, HSD17B3, SRD5A2, GATA4, B3GLCT, AKR1C2, DYNC2H1 , (...)

View the complete list with 6 more genes
Specificity
4 %
Genes
50 %
LHCGR. Complete sequencing.

By Instituto de Medicina Genomica Instituto de Medicina Genomica in Spain.

LHCGR
Specificity
100 %
Genes
50 %
Leydig cell adenoma, somatic, with precocious puberty (sequence analysis of LHCGR gene).

By CGC Genetics in Portugal.

LHCGR
Specificity
100 %
Genes
50 %
LHCGR-related Disorders via LHCGR Gene Sequencing with CNV Detection.

By PreventionGenetics PreventionGenetics in United States.

LHCGR
Specificity
100 %
Genes
50 %
Female Infertility Sequencing Panel with CNV Detection.

By PreventionGenetics PreventionGenetics in United States.

HFE, FOXL2, STAR, WT1, ARL6, MKKS, TTC8, TRIM32, CYP11A1, GALT, BBS7, BBS5, BBS12, BBS9, BBS10, BBS4, BBS1, BBS2, SOX2, CYP17A1 , (...)

View the complete list with 83 more genes
Specificity
1 %
Genes
50 %
Male Infertility Sequencing Panel with CNV Detection.

By PreventionGenetics PreventionGenetics in United States.

HFE, FOXL2, STAR, WT1, ARL6, MKKS, TTC8, TRIM32, CYP11A1, BBS7, BBS5, BBS12, BBS9, BBS10, BBS4, BBS1, BBS2, SOX2, CYP17A1, HESX1 , (...)

View the complete list with 86 more genes
Specificity
1 %
Genes
50 %
Disorders of Sex Development (DSD) and Infertility Sequencing Panel with CNV Detection.

By PreventionGenetics PreventionGenetics in United States.

HFE, FOXL2, STAR, WT1, HNF1B, HSD17B4, PITX2, ARL6, MKKS, TTC8, TRIM32, CYP11B1, TMEM70, HSD3B2, CYP11A1, HCCS, BCOR, CYB5A, GALT, BBS7 , (...)

View the complete list with 186 more genes
Specificity
1 %
Genes
50 %
Disorders of Sex Development (DSD) Sequencing Panel with CNV Detection.

By PreventionGenetics PreventionGenetics in United States.

HFE, FOXL2, STAR, WT1, HNF1B, HSD17B4, PITX2, ARL6, MKKS, TTC8, TRIM32, CYP11B1, TMEM70, HSD3B2, CYP11A1, HCCS, BCOR, CYB5A, BBS7, BBS5 , (...)

View the complete list with 138 more genes
Specificity
1 %
Genes
50 %
Infertility panel.

By Centogene AG - the Rare Disease Company in Germany.

LHCGR, FSHR, LHB, FSHB
Specificity
25 %
Genes
50 %
Leydig cell adenoma.

By Centogene AG - the Rare Disease Company in Germany.

LHCGR
Specificity
100 %
Genes
50 %
Leydig cell hypoplasia type 1.

By Centogene AG - the Rare Disease Company in Germany.

LHCGR
Specificity
100 %
Genes
50 %
Single gene testing LHCGR.

By CeGaT GmbH in Germany.

LHCGR
Specificity
100 %
Genes
50 %
qGenEx Sex development disorders.

By Quantitative Genomic Medicine Laboratories, SL in Spain.

STAR, WT1, MKKS, CYP11B1, HSD3B2, CYP11A1, CYB5A, CYP17A1, AR, ARX, DHCR7, SRY, NR0B1, LHCGR, ATRX, SOX3, POR, SOX9, RIPK4, NR5A1 , (...)

View the complete list with 28 more genes
Specificity
3 %
Genes
50 %
Leydig cell hypoplasia: LHCGR gene screening (exon 11).

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases in Spain.

LHCGR
Specificity
100 %
Genes
50 %
Leydig cell hypoplasia: LHCGR gene sequence analysis.

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases in Spain.

LHCGR
Specificity
100 %
Genes
50 %
Endocrine Disorders: Sequencing Panel.

By EGL Genetic Diagnostics Eurofins Clinical Diagnostics in United States.

HNF1A, NEUROD1, PPARG, HNF1B, WFS1, GCK, CAVIN1, CISD2, CYP17A1, CHD7, ABCC8, LMNA, NR0B1, GNRH1, FGFR1, LHCGR, KCNJ11, TACR3, KISS1R, GNRHR , (...)

View the complete list with 37 more genes
Specificity
2 %
Genes
50 %
Endocrine Disorders: Deletion/Duplication Panel.

By EGL Genetic Diagnostics Eurofins Clinical Diagnostics in United States.

HNF1A, NEUROD1, PPARG, HNF1B, WFS1, GCK, CAVIN1, CISD2, CYP17A1, CHD7, ABCC8, LMNA, NR0B1, GNRH1, FGFR1, LHCGR, KCNJ11, TACR3, KISS1R, GNRHR , (...)

View the complete list with 37 more genes
Specificity
2 %
Genes
50 %
LHCGR.

By Fulgent Genetics Fulgent Genetics in United States.

LHCGR
Specificity
100 %
Genes
50 %
Premature Ovarian Failure Panel.

By Blueprint Genetics in Finland.

FOXL2, STAR, WT1, POLG, GALT, CYP17A1, LMNA, LHCGR, POR, NR5A1, GNAS, CYP19A1, NOBOX, BMP15, FSHR
Specificity
7 %
Genes
50 %
Abnormal Genitalia/ Disorders of Sex Development Panel.

By Blueprint Genetics in Finland.

STAR, WT1, CYP11B1, HSD3B2, CYP11A1, BCOR, MKS1, CYP17A1, AR, ARX, CHD7, CREBBP, DHCR7, SRY, CDKN1C, FIG4, NR0B1, FGFR1, LHCGR, TACR3 , (...)

View the complete list with 29 more genes
Specificity
3 %
Genes
50 %
Leydig cell hypoplasia.

By Bioarray in Spain.

LHCGR
Specificity
100 %
Genes
50 %
CarrierMap.

By Recombine in United States.

FMR1, MTHFR, MCCC1, MCCC2, ABCB11, ACADM, ACADS, AGL, ACADVL, ACAT1, ALDOB, PC, USH1C, ALPL, ARG1, HLCS, ATP7A, BTD, ATP7B, BCKDHA , (...)

View the complete list with 281 more genes
Specificity
1 %
Genes
50 %
Central Precocious Puberty NGS and Deletion/Duplication Panel.

By DDC Clinic Molecular Diagnostics Laboratory DDC Clinic, Center for Special Needs Children in United States.

LHCGR, KISS1R, KISS1, MKRN3
Specificity
25 %
Genes
50 %
LHCGR Gene Sequencing and Deletion/Duplication Analysis.

By DDC Clinic Molecular Diagnostics Laboratory DDC Clinic, Center for Special Needs Children in United States.

LHCGR
Specificity
100 %
Genes
50 %
FAMILIAL GONADOTROPIN-INDEPENDENT MALE-LIMITED PRECOCIOUS PUBERTY (TESTOTOXICOSIS).

By Laboratorio de Genetica Clinica SL in Spain.

LHCGR
Specificity
100 %
Genes
50 %
Leydig Cell Hypoplasia , Sequencing LHCGR Gene.

By Reference Laboratory Genetics in Spain.

LHCGR
Specificity
100 %
Genes
50 %
Leydig Cell Hypoplasia , Sequencing Exon 11 LHCGR Gene.

By Reference Laboratory Genetics in Spain.

LHCGR
Specificity
100 %
Genes
50 %
Leydig cell agenesis.

By Labor Dr. Wisplinghoff in Germany.

LHCGR
Specificity
100 %
Genes
50 %
Phosphorus Male Infertility Panel.

By Phosphorus Diagnostics LLC in United States.

AR, CFTR, SRY, LHCGR, FSHR, FSHB, DPY19L2, AURKC, CATSPER1, USP9Y
Specificity
10 %
Genes
50 %
Phosphorus Female Infertility Panel.

By Phosphorus Diagnostics LLC in United States.

F2, F5, FMR1, FOXL2, CYP11A1, GALT, CYP17A1, LHCGR, KISS1R, GNRHR, NR5A1, GNAS, PROS1, PROC, CYP19A1, NOBOX, BMP15, FSHR, FSHB, SERPINC1 , (...)

View the complete list with 6 more genes
Specificity
4 %
Genes
50 %
Tempus xO assay.

By Tempus Labs, Inc. in United States.

BRCA1, BRCA2, VHL, APC, EPCAM, MSH2, PMS2, MSH6, MLH1, MUTYH, PTEN, RECQL4, RUNX1, TP53, ABCB11, ABCB4, FKBP10, FOXL2, HNF1A, PPARG , (...)

View the complete list with 1693 more genes
Specificity
1 %
Genes
50 %
Male infertility genetic testing.

By CEN4GEN Institute for Genomics and Molecular Diagnostics in Canada.

AR, CFTR, LHCGR, FSHR, CATSPER1
Specificity
20 %
Genes
50 %
Female infertility genetic testing.

By CEN4GEN Institute for Genomics and Molecular Diagnostics in Canada.

FMR1, LHCGR, BMP15, FSHR, LHB, ZP1
Specificity
17 %
Genes
50 %
Premature Ovarian Failure: Sequencing Panel and FMR1 CGG Repeat Analysis.

By CEN4GEN Institute for Genomics and Molecular Diagnostics in Canada.

FMR1, FOXL2, GALT, CYP17A1, EIF2B5, LMNA, EIF2B3, EIF2B2, LHCGR, POR, NR5A1, CYP19A1, HFM1, PSMC3IP, FIGLA, NOBOX, BMP15, FSHR, POF1B, GDF9 , (...)

View the complete list with 1 more genes
Specificity
5 %
Genes
50 %
Nonsyndromic disorders of sexual development: gene sequencing panel.

By CEN4GEN Institute for Genomics and Molecular Diagnostics in Canada.

STAR, HSD3B2, CYP11A1, CYP17A1, AR, LHCGR, ANOS1, POR, HSD17B3, SRD5A2, AKR1C2, CBX2
Specificity
9 %
Genes
50 %

Alternate names

Precocious Puberty, Male-limited Is also known as sexual precocity, familial, gonadotropin-independent, testotoxicosis, familial;fmpp; familial gonadotropin-independent male-limited sexual precocity; male-limited precocious puberty; testotoxicosis.



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