Ovarian Cancer

Description

Ovarian cancer, the leading cause of death from gynecologic malignancy, is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases (Chi et al., 2001). These typical features relate to the biology of the disease, which is a principal determinant of outcome (Auersperg et al., 2001). Epithelial ovarian cancer is the most common form and encompasses 5 major histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Epithelial ovarian cancer arises as a result of genetic alterations sustained by the ovarian surface epithelium (Stany et al., 2008; Soslow, 2008).

Clinical Features

Top most frequent phenotypes and symptoms related to Ovarian Cancer

  • Neoplasm
  • Pain
  • Fatigue
  • Respiratory distress
  • Vomiting
  • Abnormality of metabolism/homeostasis
  • Constipation
  • Abdominal pain
  • Weight loss
  • Gastroesophageal reflux

And another 16 symptoms. If you need more information about this disease we can help you.

Click here to know more about Mendelian.

Incidence and onset information

— Based on the latest data available OVARIAN CANCER have a estimated prevalence of 30 per 100k worldwide.
No data available about the known clinical features onset.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.

Ovarian Cancer Recommended genes panels

Panel Name, Specifity and genes Tested/covered
Hereditary High Risk Breast Cancer Panel.

By Baylor Miraca Genetics Laboratories (United States).

BRCA1, BRCA2, STK11, TP53, CDH1, PALB2, PTEN
Specificity
15 %
Genes
17 %
Hereditary High Risk Breast Cancer Panel.

By Baylor Miraca Genetics Laboratories (United States).

BRCA1, BRCA2, STK11, TP53, CDH1, PALB2, PTEN
Specificity
15 %
Genes
17 %
Comprehensive Hereditary Cancer Panel.

By Baylor Miraca Genetics Laboratories (United States).

RUNX1, SDHA, SDHB, SDHC, SDHD, BMPR1A, BRCA1, BRCA2, STK11, EPCAM, TP53, VHL, WT1, CBL, SUFU, CDC73, CDH1, CDK4, CDKN1C, CDKN2A , (...)

View the complete list with 39 more genes
Specificity
2 %
Genes
17 %
Hereditary Colorectal/Gastrointestinal Cancer Panel.

By Baylor Miraca Genetics Laboratories (United States).

BMPR1A, BRCA1, BRCA2, STK11, EPCAM, TP53, CDH1, CDK4, CDKN2A, PALB2, ENG, APC, SMAD4, MLH1, MSH2, MSH6, MUTYH, ATM, PMS1, PMS2 , (...)

View the complete list with 1 more genes
Specificity
5 %
Genes
17 %
Comprehensive breast and ovarian cancer panel testing (18 genes).

By Molecular Genetics Laboratory Centro de Investigaciones Endocrinologicas "Dr. Cesar Bergada" (Argentina).

BRCA1, BRCA2, STK11, EPCAM, TP53, CDH1, BRIP1, PALB2, MLH1, MSH2, MSH6, MUTYH, ATM, PMS2, PTEN, RAD51C, RAD51D
Specificity
6 %
Genes
17 %
Comprehensive breast cancer panel testing (10 genes).

By Molecular Genetics Laboratory Centro de Investigaciones Endocrinologicas "Dr. Cesar Bergada" (Argentina).

BRCA1, BRCA2, STK11, TP53, CDH1, BRIP1, PALB2, ATM, PTEN
Specificity
12 %
Genes
17 %
Hereditary Diffuse Gastric Cancer.

By DNA Diagnostic Laboratory Henry Ford Hospital (United States).

CDH1
Specificity
100 %
Genes
17 %
CDH1 full gene sequencing analysis.

By Clinical Molecular Diagnostic Laboratory City of Hope National Medical Center (United States).

CDH1
Specificity
100 %
Genes
17 %

You can get up to 390 more panels with our dedicated tool

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Sources and references

You can check the following sources for additional information.

OMIM ORPHANET Genetic Syndrome Finder

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