Oral Submucous Fibrosis

Description

Oral submucous fibrosis (OSMF) is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in India and Southeast Asia but rare elsewhere, and characterized by burning and pain in the oral cavity, loss of gustatory sensation, the presence of blanched fibrous bands and stiffening of the oral mucosa and oro-pharynx (leading to trismus and a progressive reduction in mouth opening) and an increased risk of developing oral squamous cell cancer (3-19%). It is usually associated with the chewing of the areca nut (an ingredient in betel quid) but the exact etiology is unknown and there is currently no effective treatment.

Clinical Features

Phenotypes and symptoms related to Oral Submucous Fibrosis

  • Flexion contracture
  • Narrow mouth
  • Trismus
  • Cheilitis
  • Abnormality of the pharynx
  • Abnormal oral cavity morphology
  • Oropharyngeal squamous cell carcinoma

Incidence and onset information

Not enough data available about incidence and published cases.
No data available about the known clinical features onset.

Alternative names

Oral Submucous Fibrosis Is also known as osmf.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.


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Oral Submucous Fibrosis Recommended genes panels

Panel Name, Specifity and genes Tested/covered
MitoMetĀ®Plus aCGH Analysis.

By Baylor Miraca Genetics Laboratories (United States).

RGS9, RHO, GRK1, RLBP1, RNASEL, BCS1L, RP1, RP2, RP9, RPE65, RPGR, RPL35A, MRPL3, RPS14, RS1, SAG, SARDH, SCO2, SCP2, SDHB , (...)

View the complete list with 612 more genes
Specificity
1 %
Genes
19 %
TGFB1 Sequence Analysis (Prenatal Diagnosis).

By Baylor Miraca Genetics Laboratories (United States).

TGFB1
Specificity
100 %
Genes
7 %
TGFB1 Sequence Analysis.

By Baylor Miraca Genetics Laboratories (United States).

TGFB1
Specificity
100 %
Genes
7 %
TGFB1 Deletion/Duplication Analysis.

By Baylor Miraca Genetics Laboratories (United States).

TGFB1
Specificity
100 %
Genes
7 %
TGFB1 Comprehensive - Sequence & Deletion/Duplication Analysis.

By Baylor Miraca Genetics Laboratories (United States).

TGFB1
Specificity
100 %
Genes
7 %
Camurati-Engelmann disease (sequence analysis TGFB1 of gene).

By CGC Genetics (Portugal).

TGFB1
Specificity
100 %
Genes
7 %
Camurati-Engelmann Disease (CED) via TGFB1 Gene Sequencing with CNV Detection.

By PreventionGenetics PreventionGenetics (United States).

TGFB1
Specificity
100 %
Genes
7 %
Skeletal Disorders and Joint Problems Sequencing Panel with CNV Detection.

By PreventionGenetics PreventionGenetics (United States).

RMRP, ROR2, RUNX2, SALL1, BMP1, BMP2, BMPR1B, SF3B4, SH3BP2, FBXW4, SHH, SHOX, SKI, SLCO2A1, SLC26A2, SMARCAL1, SMC1A, SOX9, SQSTM1, TBX15 , (...)

View the complete list with 236 more genes
Specificity
2 %
Genes
25 %

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Sources and references

You can check the following sources for additional information.

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