Narcolepsy-cataplexy Syndrome
Description
Narcolepsy with cataplexy is a sleep disorder characterized by excessive day-time sleepiness associated with uncontrollable sleep urges and cataplexy (loss of muscle tone often triggered by pleasant emotions).
Genes related to Narcolepsy-cataplexy Syndrome
- TNFSF4
- P2RY11
- MOG
- CTSH
- HCRT
- ZNF365
- HLA-DRB1
- HLA-DQB1
Clinical Features
Top most frequent phenotypes and symptoms related to Narcolepsy-cataplexy Syndrome
- Obesity
- Abnormality of the eye
- Sleep disturbance
- Syncope
- Hallucinations
- Abnormality of vision
- Slurred speech
- Cataplexy
- Excessive daytime sleepiness
- Abnormal rapid eye movement sleep
Incidence and onset information
— Based on the latest data available Narcolepsy-cataplexy Syndrome have a estimated prevalence of 25 per 100k worldwide.
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Narcolepsy-cataplexy Syndrome Recommended genes panels
Panel Name, Specifity and genes Tested/covered |
---|
AllNeuro panel.
By Centogene AG - the Rare Disease Company in Germany.
F2, F5, FMR1, HTT, HFE, MTHFR, TTR, UBE3A, VHL, PTEN, AARS2, ABHD12, ACACA, ACAD9, ACADL, ACADM, ACADS, AGL, ACADVL, ACAT1 , (...)
View the complete list with 1185 more genes
Specificity
1 %
Genes
13 % |
TNFSF4.
By Fulgent Genetics Fulgent Genetics in United States.
TNFSF4
Specificity
100 %
Genes
13 % |
Immune Report Card.
By OmniSeq, Inc. in United States.
STAT1, TGFB1, FOXP3, CCL2, CSF1R, CD40, CD40LG, CD27, CTLA4, ICOS, MS4A1, DDX58, IL10, IFNG, IL1B, CD8A, TNFSF4, TNF, CD4, CD244 , (...)
View the complete list with 27 more genes
Specificity
3 %
Genes
13 % |
P2RY11.
By Fulgent Genetics Fulgent Genetics in United States.
P2RY11
Specificity
100 %
Genes
13 % |
MOG.
By Fulgent Genetics Fulgent Genetics in United States.
MOG
Specificity
100 %
Genes
13 % |
CTSH.
By Fulgent Genetics Fulgent Genetics in United States.
CTSH
Specificity
100 %
Genes
13 % |
Narcolepsy 1 (sequence analysis of HCRT gene).
By CGC Genetics in Portugal.
HCRT
Specificity
100 %
Genes
13 % |
Narcolepsy.
By Centogene AG - the Rare Disease Company in Germany.
HCRT
Specificity
100 %
Genes
13 % |
Single gene testing HCRT.
By CeGaT GmbH in Germany.
HCRT
Specificity
100 %
Genes
13 % |
HCRT.
By Fulgent Genetics Fulgent Genetics in United States.
HCRT
Specificity
100 %
Genes
13 % |
ZNF365.
By Fulgent Genetics Fulgent Genetics in United States.
ZNF365
Specificity
100 %
Genes
13 % |
Narcolepsy Risk Factor.
By Bioscientia GmbH Center for Human Genetics in Germany.
HLA-DQB1, HLA-DRB1
Specificity
100 %
Genes
25 % |
HLA-DRB1.
By Fulgent Genetics Fulgent Genetics in United States.
HLA-DRB1
Specificity
100 %
Genes
13 % |
Tempus xT assay.
By Tempus Labs, Inc. in United States.
BRCA1, BRCA2, MTHFR, VHL, APC, EPCAM, MSH2, PMS2, MSH6, MLH1, MUTYH, PTEN, RECQL4, RUNX1, TP53, ATP7B, FOXL2, HNF1A, WT1, RB1 , (...)
View the complete list with 571 more genes
Specificity
1 %
Genes
25 % |
Narcolepsy (HLA-DQB1 06:02) Genotyping.
By ARUP Laboratories, Molecular Genetics and Genomics in United States.
HLA-DQB1
Specificity
100 %
Genes
13 % |
Celiac Disease (HLA-DQ2 and HLA-DQ8) Genotyping.
By ARUP Laboratories, Molecular Genetics and Genomics in United States.
HLA-DQB1, HLA-DQA1
Specificity
50 %
Genes
13 % |
Celiac disease (HLA-DQ/DR).
By CGC Genetics in Portugal.
HLA-DQB1, HLA-DQA1
Specificity
50 %
Genes
13 % |
Lactose intolerance (MCM6 gene) and Celiac disease (HLA-DQ2/ HLA-DQ8).
By CGC Genetics in Portugal.
HLA-DQB1, HLA-DQA1, MCM6
Specificity
34 %
Genes
13 % |
Celiac Disease via Next Generation Sequencing HLA Typing.
By PreventionGenetics PreventionGenetics in United States.
HLA-DQB1, HLA-DQA1
Specificity
50 %
Genes
13 % |
HLA DQ2/DQ8.
By Furst Medical Laboratories, FurstNAT in Norway.
HLA-DQB1, HLA-DQA1
Specificity
50 %
Genes
13 % |
Celiac Disease (HLA-DQA1*05, HLA-DQB1*02, and HLA-DQB1*03:02) Genotyping.
By Molecular Genetics Laboratory Genetrack Biolabs Inc. in Canada.
HLA-DQB1, HLA-DQA1
Specificity
50 %
Genes
13 % |
Alternate names
Narcolepsy-cataplexy Syndrome Is also known as gélineau disease.
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