Nail Disorder, Nonsyndromic Congenital, 3; Ndnc3


A white appearance of the nails can result from whitening of the nail plate (true leukonychia), the nail bed (pseudoleukonychia), or neither (apparent leukonychia), and can be due to a variety of factors including infectious, metabolic, or systemic diseases, trauma, or drugs. One of the rare causes of whitening of the nail plate is hereditary leukonychia (summary by Kiuru et al., 2011). Leukonychia may involve all of the nail (leukonychia totalis) or only part of the nail (leukonychia partialis), or can appear as one or more transverse bands (leukonychia striata) or white spots (leukonychia punctata).For a list of other nonsyndromic congenital nail disorders and a discussion of genetic heterogeneity, see NDNC1 (OMIM ).

Clinical Features

Top most frequent phenotypes and symptoms related to Nail Disorder, Nonsyndromic Congenital, 3; Ndnc3

  • Pain
  • Diabetes mellitus
  • Photophobia
  • Carious teeth
  • Palmoplantar keratoderma
  • Ectodermal dysplasia
  • Type II diabetes mellitus
  • Nephrolithiasis
  • Abnormality of the fingernails
  • Psoriasiform dermatitis
And another 13 symptoms. If you need more information about this disease we can help you.
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Incidence and onset information

Not enough data available about incidence and published cases.


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Nail Disorder, Nonsyndromic Congenital, 3; Ndnc3 Recommended genes panels

Panel Name, Specifity and genes Tested/covered

By Fulgent Genetics Fulgent Genetics in United States.

100 %
100 %

Alternate names

Nail Disorder, Nonsyndromic Congenital, 3; Ndnc3 Is also known as leukonychia totalis and/or partialis, porcelain nails;.

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