Metacarpal 4-5 Fusion; Mf4
Syndactyly type 8 is a rare, genetic, non-syndromic, congenital limb malformation characterized by unilateral or bilateral fusion of the fourth and fifth metacarpals with no other associated abnomalities. Patients present shortened fourth and fifth metacarpals with excessive separation between their distal ends, resulting in marked ulnar deviation of the little finger and an inability to bring the fifth finger in parallel with the other fingers.
Genes related to Metacarpal 4-5 Fusion; Mf4
Clinical FeaturesTop most frequent phenotypes and symptoms related to Metacarpal 4-5 Fusion; Mf4
- Inguinal hernia
- Upslanted palpebral fissure
- Thin upper lip vermilion
- Attention deficit hyperactivity disorder
- Toe syndactyly
- Triangular face
Incidence and onset information— Not enough data available about incidence and published cases.
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Metacarpal 4-5 Fusion; Mf4 Recommended genes panels
|Panel Name, Specifity and genes Tested/covered|
Isolated limb hypoplasia and limb reduction defects: Split-hand/foot; Synostosis; isolated Brachydactyly; Polydactyly; Syndactyly Panel.
By CeGaT GmbH in Germany.
TRPV4, GLI3, TP63, BMPR1B, GJA1, HOXA11, ROR2, WNT7A, LRP4, HOXD13, PTHLH, GDF5, WNT10B, BMP2, BHLHA9, IHH, FBLN1, NOG, LMBR1, FGF16
By Fulgent Genetics Fulgent Genetics in United States.
Tempus xO assay.
By Tempus Labs, Inc. in United States.
BRCA1, BRCA2, VHL, APC, EPCAM, MSH2, PMS2, MSH6, MLH1, MUTYH, PTEN, RECQL4, RUNX1, TP53, ABCB11, ABCB4, FKBP10, FOXL2, HNF1A, PPARG , (...)
View the complete list with 1693 more genes
Metacarpal 4-5 Fusion; Mf4 Is also known as ;fusion of metacarpals 4 and 5.
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