Mental Retardation, Autosomal Dominant 22; Mrd22

Description

Chromosome 1q43-q44 deletion syndrome is characterized by moderate to severe mental retardation, limited or no speech, and variable but characteristic facial features, including round face, prominent forehead, flat nasal bridge, hypertelorism, epicanthal folds, and low-set ears. Other features may include hypotonia, poor growth, microcephaly, agenesis of the corpus callosum, and seizures. The phenotype is variable, and not all features are observed in all patients, which may be explained in some cases by incomplete penetrance or variable expressivity (summary by Ballif et al., 2012).Patients with autosomal dominant mental retardation-22 have a phenotype similar to that in patients with chromosome 1q43-q44 deletion syndrome (de Munnik et al., 2014).

Clinical Features

Top most frequent phenotypes and symptoms related to Mental Retardation, Autosomal Dominant 22; Mrd22

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Generalized hypotonia
  • Microcephaly
  • Growth delay
  • Hypertelorism
  • Failure to thrive
  • Micrognathia

And another 45 symptoms. If you need more information about this disease we can help you.

Click here to know more about Mendelian.

Incidence and onset information

— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)
No data available about the known clinical features onset.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.


Mendelian

Accelerate your rare disease diagnosis with us

Learn more

Mental Retardation, Autosomal Dominant 22; Mrd22 Recommended genes panels

Panel Name, Specifity and genes Tested/covered
AllNeuro panel.

By Centogene AG - the Rare Disease Company (Germany).

BCS1L, ROR2, RPL10, BDNF, RPS6KA3, RTN2, RYR1, SACS, BIN1, SBF1, SCN10A, SCN1A, SCN1B, SCN2A, SCN3A, SCN4A, SCN5A, SCN8A, SCN9A, SCO1 , (...)

View the complete list with 1177 more genes
Specificity
1 %
Genes
100 %
ZBTB18.

By Fulgent Genetics Fulgent Genetics (United States).

ZBTB18
Specificity
100 %
Genes
100 %
Mental Retardation (Complete Panel) , Panel Massive Sequencing (NGS) 91 Genes.

By Reference Laboratory Genetics (Spain).

RPS6KA3, ST3GAL3, SLC6A8, SMARCA4, SMARCB1, ARID1A, KDM5C, STXBP1, SYNGAP1, SYP, TAF2, TSPAN7, MED12, TRIO, VLDLR, ZBTB18, ZNF711, FTSJ1, ERLIN2, CA8 , (...)

View the complete list with 71 more genes
Specificity
2 %
Genes
100 %
Autosomal Dominant Mental Retardation , Panel Massive Sequencing (NGS) 31 Genes.

By Reference Laboratory Genetics (Spain).

SMARCA4, SMARCB1, ARID1A, SYNGAP1, TRIO, ZBTB18, CACNG2, DEAF1, SETBP1, ADNP, ZMYND11, CDH15, ARID1B, POGZ, MBD5, KIRREL3, KANSL1, EHMT1, CTNNB1, TBL1XR1 , (...)

View the complete list with 11 more genes
Specificity
4 %
Genes
100 %

We have -4 more panels available in our App

Get the app

Sources and references

You can check the following sources for additional information.

MESH OMIM Rare Disease Symptoms Checker

If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like SÉZARY SYNDROME SPONDYLOEPIMETAPHYSEAL DYSPLASIA, X-LINKED; SEMDX

Need help with a diagnosis?

Learn more about how to achieve it with Mendelian


Learn more