Lipodystrophy, Partial, Acquired, With Low Complement Component C3, With Or Without Glomerulonephritis; Apldc3

Description

Acquired partial lipodystrophy (APLD) is characterized clinically by the gradual onset of bilaterally symmetrical loss of subcutaneous fat from the face, neck, upper extremities, thorax, and abdomen, in the 'cephalocaudal' sequence, sparing the lower extremities. A large group of patients (83%) with acquired partial lipodystrophy have low serum levels of complement component C3 due to the presence of C3 nephritic factor, an IgG antibody that causes continuous activation of the alternative complement pathway and consumption of serum C3. About 22% of patients with this acquired complement defect develop membranoproliferative glomerulonephritis. Some individuals may also show an increased risk of infection (Misra et al., 2004).Acquired partial lipodystrophy is not inherited in a classic mendelian pattern; it rather represents a phenotype with a complex etiology. Affected individuals may have genetic susceptibility factors that require the additional presence of environmental factors or acquired disorders to be expressed (summary by Hegele et al., 2006). Most cases are sporadic, family history is negative, and females are more often affected than males (ratio, 4:1) (summary by Misra et al., 2004).See {608709} for a subtype of APLD not associated with low complement C3 or renal disease.

Clinical Features

Top most frequent phenotypes and symptoms related to Lipodystrophy, Partial, Acquired, With Low Complement Component C3, With Or Without Glomerulonephritis; Apldc3

  • Recurrent infections
  • Diabetes mellitus
  • Proteinuria
  • Hematuria
  • Nephrotic syndrome
  • Recurrent bacterial infections
  • Lipodystrophy
  • Glomerulonephritis
  • Nephritis
  • Glucose intolerance

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Incidence and onset information

— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)
No data available about the known clinical features onset.

Alternative names

Lipodystrophy, Partial, Acquired, With Low Complement Component C3, With Or Without Glomerulonephritis; Apldc3 Is also known as lipodystrophy, partial, acquired, associated with c3 nephritic factor.

Researches and researchers

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Sources and references

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