Leukemia, Acute Myeloid; Aml

Clinical Features

Top most frequent phenotypes and symptoms related to Leukemia, Acute Myeloid; Aml

  • Seizures
  • Neoplasm
  • Pain
  • Anemia
  • Fever
  • Fatigue
  • Respiratory distress
  • Headache
  • Recurrent infections
  • Thrombocytopenia

And another 25 symptoms. If you need more information about this disease we can help you.

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Incidence and onset information

— Based on the latest data available LEUKEMIA, ACUTE MYELOID; AML have a estimated incidence of 2.5 per 100k in Europe.
No data available about the known clinical features onset.

Alternative names

Leukemia, Acute Myeloid; Aml Is also known as leukemia, acute myelogenous.

Researches and researchers

Doctors, researchs, and experts related to Leukemia, Acute Myeloid; Aml extracted from public data.

Leukemia, Acute Myeloid; Aml Experts map



Current Researchs and researchers

  • GRAZ — Pr Armin ZEBISCH

    Investigator of research project

    • Institution/s:
      — Universitätsklinik für Innere Medizin, Medizinische Universität Graz
    • Research area/topic::

      The role of RKIP in myeloid leukemogenesis


  • LINZ — Pr Andreas PETZER

    Principal investigator of clinical trial - Investigator of clinical trial - Investigator of research project

    • Institution/s:
      — Krankenhaus der Barmherzigen Schwestern Linz
    • Research area/topic::

      AMLSG BiO: Registry Study on Patient Characteristics, Biological Disease Profile and Clinical Outcome in Acute Myeloid Leukemia and Related Neoplasms, and Higher Risk Myelodysplastic Syndrome - The Biology and Outcome (BiO)-Project - AT


  • WIEN — Pr Philipp STABER

    Clinical expert - Principal investigator of clinical trial - Investigator of research project

    • Institution/s:
      — Universitätsklinik für Innere Medizin I, Allgemeines Krankenhaus der Stadt Wien
    • Research area/topic::

      EXALT: A Prospective Investigator-initiated Translational Study Evaluating Individualized Treatment Regiments Based on Respective Biomarker Analyses for Refractory Leukemia and Lymphoma Patients


  • WIEN — Pr Rotraud WIESER

    Investigator of research project

    • Institution/s:
      — Universitätsklinik für Innere Medizin I, Allgemeines Krankenhaus der Stadt Wien
    • Research area/topic::

      Functional interactions between EVI1 and atRA in LSCs (in acute myeloid leukemia)


  • LEUVEN — Pr Peter A VANDENBERGHE

    Responsible for diagnostic tests - Investigator of research project

    • Institution/s:
      — Department of Human Genetics, University Hospitals Leuven - Gasthuisberg
    • Research area/topic::

      The role of RAS- and RHO-GTPases, their regulators and mediators in the pathogenesis of myeloid malignancies.


  • TORONTO — Pr Raymond M REILLY

    Investigator of research project

    • Institution/s:
      — University of Toronto
    • Research area/topic::

      CD123-Targeted Auger Electron Radioimmunotherapy of Acute Myelogenous Leukemia (AML)


  • BERLIN — Pr Christian HAGEMEIER

    Coordinator of research network

    • Institution/s:
      — Otto-Heubner-Centrum für Kinder- und Jugendmedizin
    • Research area/topic::

      NGFN plus: Leukemia Network - functional and translational studies on acute lymphoblastic leukemia in childhood -terminated


  • DRESDEN — Dr Christoph RÖLLIG

    Principal investigator of clinical trial - Investigator of research project

    • Institution/s:
      — Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus an der TU Dresden
    • Research area/topic::

      AML Registry: Clinical AML Registry


  • DRESDEN — Dr Martin WERMKE

    Principal investigator of clinical trial - Investigator of research project

    • Institution/s:
      — Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus an der TU Dresden
    • Research area/topic::

      ALLIVE (ALLogeneic Iron inVEstigators) Observational Trial: Assessment of body, liver and labile plasma iron and their association with outcome and immunological recovery in Myelodysplastic syndromes or Acute Myeloid Leukemia patients undergoing allogeneic stem cell transplantation


  • ESSEN — Pr Dirk REINHARDT

    Coordinator of expert centre - Responsible for diagnostic tests - Principal investigator of clinical trial - Investigator of research project

    • Institution/s:
      — Zentrum für Kinder- und Jugendmedizin, Universitätsklinikum Essen
      — Westdeutsches Tumorzentrum Essen (WTZ)
    • Research area/topic::

      AML-BFM Registry 2012: Clinical registry for children and adolescents with acute myeloid leukemia


  • HANNOVER — Pr Ursula CREUTZIG

    Principal investigator of clinical trial - Investigator of research project

    • Institution/s:
      — KPOH Geschäftsführung Hannover
    • Research area/topic::

      AML-BFM Registry 2012: Clinical registry for children and adolescents with acute myeloid leukemia


  • HANNOVER — Pr Teruko TAMURA-NIEMANN

    Investigator of research project

    • Institution/s:
      — Zentrum Biochemie, Medizinische Hochschule Hannover
    • Research area/topic::

      Signal transduction of c-Kit and c-Kit related tyrosine kinases: mRNA export and hematopoesis


  • HANNOVER — Pr Roland SEIFERT

    Investigator of research project - Director of department

    • Institution/s:
      — Zentrum Pharmakologie und Toxikologie, Medizinische Hochschule Hannover
    • Research area/topic::

      The histamine H2-receptor as new target for differentiation therapy in acute myeloic leukemia


  • HEIDELBERG — Pr Olaf WITT

    Clinical expert - Principal investigator of clinical trial - Investigator of research project - Director of department

    • Institution/s:
      — Deutsches Krebsforschungszentrum
      — Deutsches Krebsforschungszentrum
    • Research area/topic::

      INFORM-Registry: INdividualized Therapy FOr Relapsed Malignancies in Childhood


  • MANNHEIM — Dr Susanne SAUßELE

    Coordinator of expert centre - Clinical expert - Principal investigator of clinical trial - Investigator of research project - Coordinator of research network

    • Institution/s:
      — III. Medizinische Universitäts-Klinik, Universitätsklinikum Mannheim
      — Universitätsmedizin Mannheim
    • Research area/topic::

      Competence Network 'acute and chronic leukemias'


  • MANNHEIM — Pr Rüdiger HEHLMANN

    Principal investigator of clinical trial - Investigator of research project - Coordinator of research network - Director of department

    • Institution/s:
      — III. Medizinische Universitäts-Klinik, Universitätsklinikum Mannheim
      — Universitätsklinikum Mannheim
    • Research area/topic::

      EUROPEAN LEUKEMIA NET: Strengthen and develop scientific and technological excellence in research and therapy of leukemia (coordination)


  • MARBURG — Pr Andreas NEUBAUER

    Coordinator of expert centre - Clinical expert - Investigator of research project - Director of department

    • Institution/s:
      — Universitätsklinikum Gießen und Marburg GmbH, Standort Marburg
      — Universitätsklinikum Gießen und Marburg GmbH, Standort Marburg
    • Research area/topic::

      Cooperation of Ras induced signaling and the nuclear oncogene Ski in acute myeloid leukemia (AML) and malignant melanoma (TRR 17: Ras-dependent pathways in human cancer)


  • ULM — Pr Christian BUSKE

    Investigator of research project

    • Institution/s:
      — Universitätsklinikum Ulm
    • Research area/topic::

      Impact of the fusion gene CALM - AF10 expression in the pathogenesis of t(10;11)(p13q14) positive leukemia (German Cancer Aid)


  • ULM — Dr Michaela FEURING-BUSKE

    Investigator of research project

    • Institution/s:
      — Universitätsklinikum Ulm
    • Research area/topic::

      Characterising normal versus leukemic stem cells in patients with acute myeloic leukemia (German Cancer Aid)


  • ULM — Pr Konstanze DÖHNER

    Clinical expert - Principal investigator of clinical trial - Investigator of research project

    • Institution/s:
      — Universitätsklinikum Ulm am Oberen Eselsberg
    • Research area/topic::

      Molecular Genetic and Functional Characterization of Candidate Genes Located in the Commonly Deleted Region at Chromosomal Bands 7q22-q31 in Myeloid Leukemias


  • ULM — Pr Hartmut DÖHNER

    Coordinator of expert centre - Principal investigator of clinical trial - Investigator of research project

    • Institution/s:
      — Universitätsklinikum Ulm am Oberen Eselsberg
      — Integratives Tumorzentrum des Universitätsklinikums Ulm
    • Research area/topic::

      ERA-NET TRANSCAN: DRAMA - Defeating Recurrence and resistance in AML: Multigenomic Approaches to analyse heterogeneity -partner DE


  • — Dr Tomasz SZCZEPANSKI

    Investigator of research project

    • Institution/s:
      — Instytut Genetyki Czlowieka - Institute of Human Genetics
    • Research area/topic::

      Assessment of treatment effectiveness in childhood acute lymphoblastic leukaemia by monitoring minimal residual disease with 8-color flow cytometry


  • CÓRDOBA — Dr Rafael SOLANA LARA

    Investigator of research project

    • Institution/s:
      — IMIBIC - Instituto Maimónides de Investigación Biomédica de Córdoba
    • Research area/topic::

      Implications of immunosenescence in the design of antitumor immunotherapy protocols based on NK cells in melanoma and acute myeloid leukemia models


  • LAS PALMAS — Dr Cristina BILBAO SIEYRO

    Investigator of research project

    • Institution/s:
      — Hospital Universitario de Gran Canaria, Doctor Negrín
    • Research area/topic::

      Implication of the epigenetic regulators BRD4, EZH2 and ASXL1 in acute myeloid leukemia


  • MADRID — Dr Rosa AYALA DÍAZ

    Principal investigator of clinical trial - Investigator of research project

    • Institution/s:
      — Hospital Universitario 12 de Octubre
      — Instituto de Investigación Hospital 12 de Octubre
    • Research area/topic::

      Molecular alterations involved in the mechanisms of refractoriness and relapse of Acute Myeloid Leukemia: Therapeutic Implications


  • VALENCIA — Dr Pau MONTESINOS FERNÁNDEZ

    Principal investigator of clinical trial - Investigator of research project - Manager of registry

    • Institution/s:
      — Hospital Universitario y Politécnico La Fe
    • Research area/topic::

      VILMA: Therapeutic Results in Acute Mieloblastic Leukemia in Patients Older Than 60 Years or Not Candidates for Intensive Chemotherapy - ES


  • VALENCIA — Dr Miguel Angel SANZ ALONSO

    Coordinator of expert centre - Clinical expert - Principal investigator of clinical trial - Investigator of clinical trial - Investigator of research project - Director of department

    • Institution/s:
      — Hospital Universitario y Politécnico La Fe
      — IIS La Fe - Instituto de Investigación Sanitaria La Fe
      — Servicio de Hematología, Hospital Universitario y Politécnico La Fe
    • Research area/topic::

      Tracking and validation of mutations in the non-coding regions and spliceosome genes in acute myeloblastic leukemia (AML)


  • HUDDINGE — Pr Eva HELLSTRÖM-LINDBERG

    Clinical expert - Investigator of research project

    • Institution/s:
      — Karolinska Universitetssjukhuset - Solna
      — Karolinska Institutet, Karolinska Institutet - Huddinge
    • Research area/topic::

      Molecular pathogenesis in myelodysplastic syndromes and acute myeloid leukemia


  • STOCKHOLM — Pr Eva HELLSTRÖM-LINDBERG

    Clinical expert - Investigator of research project

    • Institution/s:
      — Karolinska Universitetssjukhuset - Solna
      — Karolinska Institutet, Karolinska Institutet - Huddinge
    • Research area/topic::

      Molecular pathogenesis in myelodysplastic syndromes and acute myeloid leukemia


  • STOCKHOLM — Dr Sören LEHMANN

    Investigator of research project

    • Institution/s:
      — Karolinska Universitetssjukhuset - Huddinge
    • Research area/topic::

      Study of chemotherapy resistance and DNA methylation in acute myeloid leukemia samples



Mendelian

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Leukemia, Acute Myeloid; Aml Recommended genes panels

Panel Name, Specifity and genes Tested/covered
KRAS Sequence Analysis.

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5 %
KRAS Sequence Analysis (Familial Mutation/Variant Analysis).

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Genes
5 %
KRAS Sequence Analysis (Prenatal Diagnosis).

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PreSeek Non-invasive Prenatal Gene Sequencing Screen.

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RIT1, BRAF, SMC1A, SOS1, SOS2, CDKL5, SYNGAP1, TSC1, TSC2, HDAC8, NSD1, CBL, SHOC2, CHD7, COL1A2, SMC3, NIPBL, FGFR2, FGFR3, HRAS , (...)

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Specificity
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KRAS/RAF1/SOS1 DNA Sequencing Evaluation.

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SOS1, KRAS, RAF1
Specificity
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KRAS DNA Sequencing Test.

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Non-immune Hydrops Panel.

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RIT1, RPL11, RPL35A, RPL5, RPS10, RPS17, RPS19, RPS24, RPS26, SEC23B, SLC17A5, BRAF, SMPD1, SOS1, SOS2, SOX18, UROS, CBL, SHOC2, ALG9 , (...)

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Specificity
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NGS RASopathy Panel.

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RIT1, RRAS, BRAF, SOS1, SOS2, CBL, SHOC2, KAT6B, SPRED1, A2ML1, CABIN1, NSUN2, HRAS, KRAS, LZTR1, MAP2K1, MAP2K2, NF1, NF2, NRAS , (...)

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Sources and references

You can check the following sources for additional information.

OMIM ORPHANET Rare Disease Symptoms Checker

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