Kawasaki Disease

Description

Kawasaki disease (KD) is a febrile, systemic, self-limiting vasculitis affecting children and characterized by inflammation in the medium sized vessels associated with coronary arterial aneurysms (CAA) that may be life threatening when untreated. KD is the most common cause of acquired heart disease in children in developed countries and is a risk factor for ischemic heart disease in adulthood.

Clinical Features

Top most frequent phenotypes and symptoms related to Kawasaki Disease

  • Sensorineural hearing impairment
  • Ptosis
  • Fever
  • Fatigue
  • Edema
  • Diarrhea
  • Congestive heart failure
  • Headache
  • Dilatation
  • Arrhythmia

And another 61 symptoms. If you need more information about this disease we can help you.

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Incidence and onset information

Not enough data available about incidence and published cases.
No data available about the known clinical features onset.

Alternative names

Kawasaki Disease Is also known as kd, infantile polyarteritis, mucocutaneous lymph node syndrome.

Researches and researchers

Doctors, researchs, and experts related to Kawasaki Disease extracted from public data.

Kawasaki Disease Experts map



Current Researchs and researchers

  • TORONTO — Dr Rae SM YEUNG

    Investigator of research project

    • Institution/s:
      — The Hospital for Sick Children
    • Research area/topic::

      Kawasaki Disease: On our way to unraveling the pathogenesis


  • PARIS — Pr Loïc GUILLEVIN

    Coordinator of expert centre - Clinical expert - Principal investigator of clinical trial - Manager of registry - Contact person of registry - Coordinator of research network

    • Institution/s:
      — CHU Paris Centre - Hôpital Cochin, Site Cochin
    • Research area/topic::

      GFEV: French study group on vasculitis - research organization on necrotising angeitis, systemic diseases and vaccinale research


  • CAMBRIDGE — Dr David JAYNE

    Coordinator of expert centre - Principal investigator of clinical trial - Investigator of clinical trial - Coordinator of research network

    • Institution/s:
      — Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital
    • Research area/topic::

      EUVAS: European vasculitis study group


  • LONDON — Dr Paul A BROGAN

    Clinical expert - Principal investigator of clinical trial - Investigator of research project - Contact person of registry

    • Institution/s:
      — Rheumatology Unit, UCL Institute of Child Health, University College London
      — University College London (UCL), The Institute of Child Health & The Division of Medicine, UCL
    • Research area/topic::

      Predisposition to premature atherosclerosis later in life of patients affected by Kawasaki disease



Mendelian

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Kawasaki Disease Recommended genes panels

Panel Name, Specifity and genes Tested/covered
Epilepsy Advanced Sequencing and CNV Evaluation.

By Athena Diagnostics Inc (United States).

SCN1A, SCN1B, SCN2A, SCN3A, SCN5A, SCN8A, SCN9A, SHH, ST3GAL3, ST3GAL5, STIL, SIX3, SLC2A1, SLC35A2, SLC6A1, SLC6A8, SLC9A6, SMC1A, KDM5C, SMS , (...)

View the complete list with 214 more genes
Specificity
1 %
Genes
3 %
Epilepsy Advanced Sequencing and CNV Evaluation - Syndromic Disorders.

By Athena Diagnostics Inc (United States).

SYNGAP1, TBX1, TSC1, TSC2, SETBP1, PANK2, ADGRV1, ATP6V0A2, MAGI2, VPS13A, ANKRD11, VPS13B, KIF1BP, KANSL1, SMC3, PIGV, NIPBL, ROGDI, GFAP, HPRT1 , (...)

View the complete list with 11 more genes
Specificity
4 %
Genes
3 %
Syndromic Autism Panel.

By Greenwood Genetic Center Diagnostic Laboratories Greenwood Genetic Center (United States).

SCN1A, SCN2A, BRAF, SLC2A1, SLC9A6, SMC1A, KDM5C, CDKL5, STXBP1, TBR1, TCF4, MED12, TSC1, TSC2, UBE3A, HDAC8, CNTNAP2, FOXP2, CACNA1C, NSD1 , (...)

View the complete list with 63 more genes
Specificity
2 %
Genes
3 %
Juvenile Myelomonocytic Leukemia.

By UCSF Molecular Diagnostics Laboratory University of California, San Francisco (United States).

CBL, SETBP1, RRAS2, ASXL1, SH2B3, JAK3, KRAS, NF1, NRAS, PTPN11
Specificity
10 %
Genes
3 %
MyeloidDx by NGS.

By Molecular Genetics Diagnostic Laboratory Detroit Medical Center University Laboratories (United States).

RUNX1, SF3B1, SRSF2, BRAF, SMC1A, STAG2, TP53, U2AF1, KDM6A, WT1, IKZF1, CALR, CBL, CBLB, SETBP1, FBXW7, CDKN2A, PHF6, ASXL1, CEBPA , (...)

View the complete list with 32 more genes
Specificity
2 %
Genes
3 %
MyeloidDx by NGS.

By Molecular Genetics Diagnostic Laboratory Detroit Medical Center University Laboratories (United States).

RUNX1, SF3B1, SRSF2, BRAF, SMC1A, STAG2, TP53, U2AF1, KDM6A, WT1, IKZF1, CALR, CBL, CBLB, SETBP1, CBLC, FBXW7, CDKN2A, PHF6, CEBPA , (...)

View the complete list with 31 more genes
Specificity
2 %
Genes
3 %
SETBP1 sequencing.

By Genetic Services Laboratory University of Chicago (United States).

SETBP1
Specificity
100 %
Genes
3 %
Abnormal/Ambiguous Genitalia Sequencing Panel.

By Genetic Services Laboratory University of Chicago (United States).

ROR2, SALL1, BMP4, SEMA3A, SOX9, SRD5A2, SRY, STAR, TBX15, CEP41, TSPYL1, WNT4, WNT7A, WT1, SETBP1, ZFPM2, UBR1, FIG4, IL17RD, CDKN1C , (...)

View the complete list with 52 more genes
Specificity
2 %
Genes
3 %

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Sources and references

You can check the following sources for additional information.

OMIM ORPHANET MESH Rare Disease Search Engine

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