Hereditary Breast And Ovarian Cancer Syndrome

Description

Breast cancer (BC) is the most common cancer in women, accounting for 25% of all new cases of cancer. Most BC cases are sporadic, while 5-10% are estimated to be due to an inherited predisposition.

Clinical Features

Top most frequent phenotypes and symptoms related to Hereditary Breast And Ovarian Cancer Syndrome

  • Neoplasm
  • Carcinoma
  • Melanoma
  • Breast carcinoma
  • Ovarian neoplasm
  • Neoplasm of the pancreas
  • Prostate cancer
  • Ovarian carcinoma
  • Abnormality of the fallopian tube
  • Ovarian papillary adenocarcinoma

And another 1 symptoms. If you need more information about this disease we can help you.

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Incidence and onset information

— Based on the latest data available HEREDITARY BREAST AND OVARIAN CANCER SYNDROME have a estimated prevalence of 25 per 100k worldwide.
No data available about the known clinical features onset.

Researches and researchers

Doctors, researchs, and experts related to Hereditary Breast And Ovarian Cancer Syndrome extracted from public data.

Hereditary Breast And Ovarian Cancer Syndrome Experts map



Current Researchs and researchers

  • ULM — Pr Walther VOGEL

    Investigator of research project

    • Institution/s:
      — Universitätsklinikum Ulm
    • Research area/topic::

      Genetic variation in DNA-Repair and carcinoma susceptibility


  • BARCELONA — Dr Jordi SURRALLÉS CALONGE

    Responsible for diagnostic tests - Investigator of research project - Manager of biobank/collection - Coordinator of research network - Director of laboratory

    • Institution/s:
      — Universitat Autònoma de Barcelona
      — Hospital de la Santa Creu i Sant Pau
    • Research area/topic::

      New assay based on synthetic lethality for the functional analysis of variants of uncertain significance in breast cancer / familial ovary associated genes


  • BELLATERRA — Dr Jordi SURRALLÉS CALONGE

    Responsible for diagnostic tests - Investigator of research project - Manager of biobank/collection - Coordinator of research network - Director of laboratory

    • Institution/s:
      — Universitat Autònoma de Barcelona
      — Hospital de la Santa Creu i Sant Pau
    • Research area/topic::

      New assay based on synthetic lethality for the functional analysis of variants of uncertain significance in breast cancer / familial ovary associated genes


  • ROCHESTER — Gloria PETERSEN

    Investigator of research project

    • Institution/s:
      — Mayo Clinic Rochester
    • Research area/topic::

      Disclosing genomic incidental findings in a cancer biobank: an elsi experiment



Mendelian

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Hereditary Breast And Ovarian Cancer Syndrome Recommended genes panels

Panel Name, Specifity and genes Tested/covered
PTEN Comprehensive - Sequence & Deletion/Duplication Analysis.

By Baylor Miraca Genetics Laboratories (United States).

PTEN
Specificity
100 %
Genes
8 %
PTEN Deletion/Duplication Analysis.

By Baylor Miraca Genetics Laboratories (United States).

PTEN
Specificity
100 %
Genes
8 %
PTEN Deletion/Duplication Analysis (Prenatal Diagnosis).

By Baylor Miraca Genetics Laboratories (United States).

PTEN
Specificity
100 %
Genes
8 %
PTEN Sequence Analysis.

By Baylor Miraca Genetics Laboratories (United States).

PTEN
Specificity
100 %
Genes
8 %
PTEN Sequence Analysis (Familial Mutation/Variant Analysis).

By Baylor Miraca Genetics Laboratories (United States).

PTEN
Specificity
100 %
Genes
8 %
PTEN Sequence Analysis (Prenatal Diagnosis).

By Baylor Miraca Genetics Laboratories (United States).

PTEN
Specificity
100 %
Genes
8 %
Hereditary High Risk Breast Cancer Panel.

By Baylor Miraca Genetics Laboratories (United States).

BRCA1, BRCA2, STK11, TP53, CDH1, PALB2, PTEN
Specificity
72 %
Genes
36 %
Hereditary High Risk Breast Cancer Panel.

By Baylor Miraca Genetics Laboratories (United States).

BRCA1, BRCA2, STK11, TP53, CDH1, PALB2, PTEN
Specificity
72 %
Genes
36 %

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Sources and references

You can check the following sources for additional information.

OMIM ORPHANET Rare Disease Symptoms Checker

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