Hemangioma, Capillary Infantile

Description

Capillary hemangiomas are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births (Mulliken and Young, 1988). Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma. Hemangiomas are classified as distinct from vascular malformations (see, e.g., CMC1, {163000}; {108010}; and CCM, {116860}), in that the latter are present from birth, tend to grow with the individual, do not regress, and show normal rates of endothelial cell turnover (Spring and Bentz, 2005; Legiehn and Heran, 2006). Legiehn and Heran (2006) noted that the term 'hemangioma' in adults is considered inaccurate and should be discarded.Most hemangiomas occur sporadically, but some families with autosomal dominant inheritance have been reported (Walter et al., 1999).

Clinical Features

Phenotypes and symptoms related to Hemangioma, Capillary Infantile

  • Neoplasm
  • Hemangioma
  • Capillary hemangioma

Incidence and onset information

— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)
No data available about the known clinical features onset.

Alternative names

Hemangioma, Capillary Infantile Is also known as hci, hemangioma, hereditary capillary.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.


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Hemangioma, Capillary Infantile Recommended genes panels

Panel Name, Specifity and genes Tested/covered
NGS Vascular Disorders Panel.

By Greenwood Genetic Center Diagnostic Laboratories Greenwood Genetic Center (United States).

SOX18, TEK, VEGFC, GLMN, KRIT1, STAMBP, GJC2, ACVRL1, CCM2, CCBE1, ENG, FLT4, FOXC2, GATA2, GDF2, KIF11, SMAD4, PDCD10, PTEN, PTPN14 , (...)

View the complete list with 1 more genes
Specificity
5 %
Genes
34 %
FLT4.

By Institute for Human Genetics University Clinic Freiburg (Germany).

FLT4
Specificity
100 %
Genes
34 %
Lymphedema NGS Multi-Gene Panel (36 Genes).

By Laboratory of genome diagnostics Academic Medical Center, University of Amsterdam (Netherlands).

BRAF, SOS1, SOX18, VEGFC, CBL, SHOC2, GJC2, TUBGCP6, CDK19, SPRED1, FAT4, ALG8, CCBE1, FLT4, FOXC2, GATA2, GJA1, GLA, HGF, HRAS , (...)

View the complete list with 16 more genes
Specificity
3 %
Genes
34 %
FLT4. Complete sequencing.

By Instituto de Medicina Genomica Instituto de Medicina Genomica (Spain).

FLT4
Specificity
100 %
Genes
34 %
Milroy disease (sequence analysis of 17 to 26 exon of FLT4 gene).

By CGC Genetics (Portugal).

FLT4
Specificity
100 %
Genes
34 %
Milroy disease (sequence analysis of FLT4 gene).

By CGC Genetics (Portugal).

FLT4
Specificity
100 %
Genes
34 %
Lymphedema Sequencing Panel with CNV Detection.

By PreventionGenetics PreventionGenetics (United States).

SOX18, VEGFC, GJC2, FAT4, PIEZO1, CCBE1, FLT4, FOXC2, GATA2, GJA1, KIF11, PTPN14
Specificity
9 %
Genes
34 %
Milroy Disease (Lymphedema Type I) via FLT4 Gene Sequencing with CNV Detection.

By PreventionGenetics PreventionGenetics (United States).

FLT4
Specificity
100 %
Genes
34 %

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Sources and references

You can check the following sources for additional information.

ORPHANET MESH OMIM Genetic Syndrome Finder

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