Glomerulopathy With Fibronectin Deposits 1; Gfnd1

Description

Glomerulopathy with fibronectin deposits (GFND) is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. Pathologic examination shows enlarged glomeruli with mesangial and subendothelial fibrillary deposits that show strong immunoreactivity to fibronectin (FN1 ) (Castelletti et al., 2008). Genetic Heterogeneity of Glomerulopathy with Fibronectin DepositsThe GFND1 locus maps to chromosome 1q32. See also GFND2 (OMIM ), which is caused by mutation in the FN1 gene (OMIM ) on chromosome 2q35.

Clinical Features

Top most frequent phenotypes and symptoms related to Glomerulopathy With Fibronectin Deposits 1; Gfnd1

  • Hypertension
  • Edema
  • Renal insufficiency
  • Acidosis
  • Carcinoma
  • Proteinuria
  • Stroke
  • Stage 5 chronic kidney disease
  • Nephropathy
  • Hematuria

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Incidence and onset information

— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)
No data available about the known clinical features onset.

Alternative names

Glomerulopathy With Fibronectin Deposits 1; Gfnd1 Is also known as glomerulopathy with giant fibrillar deposits, lobular glomerulopathy, familial.

Researches and researchers

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Sources and references

You can check the following sources for additional information.

OMIM Genetic Syndrome Finder

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