Gamma-glutamylcysteine Synthetase Deficiency, Hemolytic Anemia Due To

Description

Gamma-glutamylcysteine synthetase deficiency is 1 of 4 diseases involving enzymes in the gamma-glutamyl cycle (Meister, 1974). The other 3 disorders are glutathione synthetase deficiency (OMIM ), 5-oxoprolinuria, which is a severe or generalized form of glutathione synthetase deficiency (OMIM ), and gamma-glutamyl transpeptidase deficiency (OMIM ). All except gamma-glutamyl transpeptidase deficiency are accompanied by hemolytic anemia (Larsson and Anderson, 2001).

Clinical Features

Phenotypes and symptoms related to Gamma-glutamylcysteine Synthetase Deficiency, Hemolytic Anemia Due To

  • Myopathy
  • Anemia
  • Abnormality of metabolism/homeostasis
  • Hemolytic anemia
  • Polyneuropathy
  • Spinocerebellar tract degeneration
  • Nonspherocytic hemolytic anemia
  • Late-onset spinocerebellar degeneration

Incidence and onset information

Not enough data available about incidence and published cases.


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Gamma-glutamylcysteine Synthetase Deficiency, Hemolytic Anemia Due To Recommended genes panels

Panel Name, Specifity and genes Tested/covered
Red Blood Cell Enzymopathies Panel by Next Generation Sequencing (NGS).

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center in United States.

ALDOA, GPX1, GPI, AK1, NT5C3A, HK1, PFKM, G6PD, PKLR, PGK1, GCLC, GSR, TPI1, GSS
Specificity
8 %
Genes
100 %
Hemolytic Anemia Panel by next-generation sequencing (NGS).

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center in United States.

ALDOA, ALAS2, GPX1, GPI, AK1, NT5C3A, HK1, PFKM, SLC2A1, G6PD, COL4A1, PIEZO1, KIF23, GATA1, KLF1, PKLR, CDAN1, SEC23B, PGK1, ABCG5 , (...)

View the complete list with 18 more genes
Specificity
3 %
Genes
100 %
GCLC Sequencing.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center in United States.

GCLC
Specificity
100 %
Genes
100 %
GCLC Deletion/duplication analysis.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center in United States.

GCLC
Specificity
100 %
Genes
100 %
Hemolytic Anemia Deletion/Duplication Panel.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center in United States.

ALDOA, GPX1, GPI, AK1, NT5C3A, HK1, PFKM, SLC2A1, G6PD, PIEZO1, KIF23, GATA1, KLF1, PKLR, CDAN1, SEC23B, PGK1, ABCG5, ABCG8, SLC4A1 , (...)

View the complete list with 14 more genes
Specificity
3 %
Genes
100 %
Red Blood Cell Enzymopathies Deletion/Duplication Panel.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center in United States.

ALDOA, GPX1, GPI, AK1, NT5C3A, HK1, PFKM, G6PD, PKLR, PGK1, GCLC, GSR, TPI1, GSS
Specificity
8 %
Genes
100 %
Ataxia Exome Panel.

By Genetic Services Laboratory University of Chicago in United States.

FMR1, TTR, UBE3A, AARS2, ABHD12, PC, UQCRQ, UQCRB, HLCS, BTD, ATP7B, ATPAF2, AUH, BCKDHA, BCKDHB, BCS1L, TWNK, C12orf65, ADSL, PRKCG , (...)

View the complete list with 460 more genes
Specificity
1 %
Genes
100 %
Hereditary Hemolytic Anemia Sequencing, 28 Genes.

By ARUP Laboratories, Molecular Genetics and Genomics in United States.

ALDOA, GPI, AK1, NT5C3A, CYB5R3, HK1, PFKM, ADA, G6PD, UGT1A1, PIEZO1, PKLR, PGK1, SLC4A1, EPB41, SPTB, SPTA1, ANK1, EPB42, GCLC , (...)

View the complete list with 8 more genes
Specificity
4 %
Genes
100 %
RBC Enzymopathies (NGS panel of 14 genes).

By CGC Genetics in Portugal.

ALDOA, GPX1, GPI, AK1, NT5C3A, HK1, PFKM, G6PD, PKLR, PGK1, GCLC, GSR, TPI1, GSS
Specificity
8 %
Genes
100 %
Gamma-glutamylcysteine synthetase deficiency (sequence analysis of GCLC gene).

By CGC Genetics in Portugal.

GCLC
Specificity
100 %
Genes
100 %
NGS Panel for Hereditary hemolytic anemia including membranopathies (spherocytosis, elliptocytosis, xerocytosis, stomatocytosis, pyropoikylocytosis) and enzymopathies.

By BLOODGENETICS BLOODGENETICS in Spain.

ALDOA, ABCB6, GPX1, GPI, AK1, NT5C3A, CYB5R3, HK1, PFKM, ADA, SLC2A1, G6PD, UGT1A1, PIEZO1, PKLR, PGK1, ABCG5, ABCG8, SLC4A1, GYPC , (...)

View the complete list with 13 more genes
Specificity
4 %
Genes
100 %
Hereditary Hemolytic Anemia Comprehensive Sequencing, Varies.

By Mayo Clinic Genetic Testing Laboratories Mayo Clinic in United States.

ALDOA, HBB, GPI, AK1, NT5C3A, HK1, PFKM, FANCC, RPS19, SLC2A1, G6PD, UGT1A1, PIEZO1, KIF23, GATA1, KLF1, PKLR, CDAN1, SEC23B, PGK1 , (...)

View the complete list with 20 more genes
Specificity
3 %
Genes
100 %
GCLC.

By Fulgent Genetics Fulgent Genetics in United States.

GCLC
Specificity
100 %
Genes
100 %

Alternate names

Gamma-glutamylcysteine Synthetase Deficiency, Hemolytic Anemia Due To Is also known as ;gamma-glutamylcysteine synthetase deficiency.



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