Familial Or Sporadic Hemiplegic Migraine

Description

Hemiplegic migraine (HM) is a rare variety of migraine with aura characterized by the presence of a motor weakness during the aura. Hemiplegic migraine has two main forms depending on the familial history: patients with at least one first- or second-degree relative who has aura including motor weakness have familial hemiplegic migraine (FHM); patients without such familial history have sporadic hemiplegic migraine (SHM).

Clinical Features

Top most frequent phenotypes and symptoms related to Familial Or Sporadic Hemiplegic Migraine

  • Seizures
  • Ataxia
  • Nystagmus
  • Sensorineural hearing impairment
  • Blindness
  • Vomiting
  • Headache
  • Photophobia
  • EEG abnormality
  • Neurological speech impairment

And another 11 symptoms. If you need more information about this disease we can help you.

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Incidence and onset information

— Based on the latest data available FAMILIAL OR SPORADIC HEMIPLEGIC MIGRAINE have a estimated prevalence of 10 per 100k worldwide.
No data available about the known clinical features onset.

Researches and researchers

Doctors, researchs, and experts related to Familial Or Sporadic Hemiplegic Migraine extracted from public data.

Familial Or Sporadic Hemiplegic Migraine Experts map



Current Researchs and researchers

  • MÜNCHEN — Pr Martin DICHGANS

    Clinical expert - Responsible for diagnostic tests - Investigator of research project - Coordinator of research network - Director of laboratory

    • Institution/s:
      — Neurologische Klinik und Poliklinik, LMU Klinikum der Universität München - Campus Großhadern
      — Klinikum der Universität München
    • Research area/topic::

      Genetics of familial and sporadic hemiplegic migraine (Investigations on CACNA1A, ATP1A2 und SCN1A genes)


  • TÜBINGEN — Dr Tobias FREILINGER

    Investigator of research project

    • Institution/s:
      — Zentrum für Neurologie, Hertie-Institut für klinische Hirnforschung (HIH)
    • Research area/topic::

      Genetics of familial and sporadic hemiplegic migraine (Investigations on CACNA1A, ATP1A2 und SCN1A genes)


  • MILANO — Dr Maria Pia ABBRACCHIO

    Investigator of research project

    • Institution/s:
      — Università degli Studi di Milano - Scienze Farmacologiche e Biomolecolari
    • Research area/topic::

      Genetic and micro-environmental factors regulate the role of atp as transmitter of pain in a migraine model


  • PADOVA — Pr Daniela PIETROBON

    Investigator of research project

    • Institution/s:
      — Università degli Studi di Padova- Polo A.Vallisneri
    • Research area/topic::

      Familial hemiplegic migraine mechanisms


  • PORTO — Pr Isabel SILVEIRA

    Investigator of research project

    • Institution/s:
      — Instituto de Biologia Molecular e Celular
    • Research area/topic::

      CACNA1A gene involvement in cognition and synaptic function in calcium channel disease.


  • PORTO — Dr Isabel ALONSO

    Responsible for diagnostic tests - Investigator of research project

    • Institution/s:
      — Instituto de Biologia Molecular e Celular
      — Instituto de Biologia Molecular e Celular
    • Research area/topic::

      Search for disease modifiers in spinocerebellar ataxias: human and animal-based approaches.



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Familial Or Sporadic Hemiplegic Migraine Recommended genes panels

Panel Name, Specifity and genes Tested/covered
SCA6 (CACNA1A) Repeat Expansion Test.

By Athena Diagnostics Inc (United States).

CACNA1A
Specificity
100 %
Genes
25 %
Ataxia, Common Repeat Expansion Evaluation.

By Athena Diagnostics Inc (United States).

ATXN1, ATXN10, ATXN2, ATXN7, ATXN8OS, TBP, CACNA1A, ATXN3
Specificity
13 %
Genes
25 %
Episodic Ataxia Evaluation.

By Athena Diagnostics Inc (United States).

SLC1A3, CACNA1A, CACNB4, KCNA1
Specificity
25 %
Genes
25 %
Ataxia, Comprehensive Evaluation.

By Athena Diagnostics Inc (United States).

SACS, ATXN1, ATXN10, ATXN2, ATXN7, ATXN8OS, SLC1A3, SPTBN2, TBP, TTPA, VAMP1, CACNA1A, CACNB4, APTX, TGM6, COQ8A, SYNE1, TDP1, TTBK2, SYT14 , (...)

View the complete list with 22 more genes
Specificity
3 %
Genes
25 %
Ataxia, Supplemental Dominant Evaluation.

By Athena Diagnostics Inc (United States).

SLC1A3, SPTBN2, VAMP1, CACNA1A, CACNB4, TGM6, TTBK2, AFG3L2, EEF2, FGF14, ITPR1, KCNA1, KCNC3, KCND3, PDYN, PRKCG
Specificity
7 %
Genes
25 %
Ataxia, Complete Dominant Evaluation.

By Athena Diagnostics Inc (United States).

ATXN1, ATXN10, ATXN2, ATXN7, ATXN8OS, SLC1A3, SPTBN2, TBP, VAMP1, CACNA1A, CACNB4, TGM6, TTBK2, ATN1, AFG3L2, EEF2, FGF14, ITPR1, KCNA1, KCNC3 , (...)

View the complete list with 5 more genes
Specificity
4 %
Genes
25 %
Hemiplegic Migraine Sequencing Evaluation.

By Athena Diagnostics Inc (United States).

SCN1A, CACNA1A, ATP1A2
Specificity
100 %
Genes
75 %
CACNA1A Sequencing Test.

By Athena Diagnostics Inc (United States).

CACNA1A
Specificity
100 %
Genes
25 %

We have 342 more panels available in our App

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Sources and references

You can check the following sources for additional information.

OMIM ORPHANET Genetic Syndrome Finder

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