Colorectal Cancer, Hereditary Nonpolyposis, Type 5; Hnpcc5

Description

Hereditary nonpolyposis colorectal cancer type 5 is a cancer predisposition syndrome characterized by onset of colorectal cancer and/or extracolonic cancers, particularly endometrial cancer, usually in mid-adulthood. The disorder shows autosomal dominant inheritance with incomplete penetrance (summary by Castellsague et al., 2015).For a phenotypic description and a discussion of genetic heterogeneity of hereditary nonpolyposis colorectal cancer (HNPCC), see HNPCC1 (OMIM ).

Clinical Features

Top most frequent phenotypes and symptoms related to Colorectal Cancer, Hereditary Nonpolyposis, Type 5; Hnpcc5

  • Neoplasm
  • Carcinoma
  • Lymphoma
  • Breast carcinoma
  • Colon cancer
  • Ovarian neoplasm
  • Hodgkin lymphoma
  • Neoplasm of the pancreas
  • Stomach cancer
  • Ovarian carcinoma

And another 2 symptoms. If you need more information about this disease we can help you.

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Incidence and onset information

Not enough data available about incidence and published cases.
No data available about the known clinical features onset.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.


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Colorectal Cancer, Hereditary Nonpolyposis, Type 5; Hnpcc5 Recommended genes panels

Panel Name, Specifity and genes Tested/covered
HNPCC MSI & IHC Screening.

By Baylor Miraca Genetics Laboratories (United States).

EPCAM, MLH1, MSH2, MSH6, PMS2
Specificity
20 %
Genes
100 %
MSH6 Comprehensive - Sequence & Deletion/Duplication Analysis.

By Baylor Miraca Genetics Laboratories (United States).

MSH6
Specificity
100 %
Genes
100 %
MSH6 Deletion/Duplication Analysis.

By Baylor Miraca Genetics Laboratories (United States).

MSH6
Specificity
100 %
Genes
100 %
MSH6 Sequence Analysis.

By Baylor Miraca Genetics Laboratories (United States).

MSH6
Specificity
100 %
Genes
100 %
MSH6 Sequence Analysis (Familial Mutation/Variant Analysis).

By Baylor Miraca Genetics Laboratories (United States).

MSH6
Specificity
100 %
Genes
100 %
Mismatch Repair Proteins Immunohistochemistry.

By Baylor Miraca Genetics Laboratories (United States).

MLH1, MSH2, MSH6, PMS2
Specificity
25 %
Genes
100 %
Hereditary Brain, CNS, PNS Cancer Panel.

By Baylor Miraca Genetics Laboratories (United States).

TP53, VHL, SUFU, PALB2, ALK, APC, MEN1, MLH1, MRE11, MSH2, MSH6, NBN, NF2, ATM, PMS2, PHOX2B, PTCH1
Specificity
6 %
Genes
100 %
Hereditary Brain, CNS, PNS Cancer Panel.

By Baylor Miraca Genetics Laboratories (United States).

TP53, VHL, SUFU, PALB2, ALK, APC, MEN1, MLH1, MRE11, MSH2, MSH6, NBN, NF2, ATM, PMS2, PHOX2B, PTCH1
Specificity
6 %
Genes
100 %

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Sources and references

You can check the following sources for additional information.

MESH OMIM Rare Disease Symptoms Checker

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