1. Mendelian
  2. Rare Diseases
  3. AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IIA; ALPS2A

Autoimmune Lymphoproliferative Syndrome, Type Iia; Alps2a

Table of contents:

Genes related to Autoimmune Lymphoproliferative Syndrome, Type Iia; Alps2a

  • CASP10

View recommended genes panels

Clinical Features

Top most frequent phenotypes and symptoms related to Autoimmune Lymphoproliferative Syndrome, Type Iia; Alps2a

  • Anemia
  • Hepatomegaly
  • Fever
  • Splenomegaly
  • Thrombocytopenia
  • Hepatosplenomegaly
  • Skin rash
  • Lymphadenopathy
  • Hemolytic anemia
  • Gastrointestinal hemorrhage

And another 31 symptoms. If you need more information about this disease we can help you.

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Incidence and onset information

— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)
— No data available about the known clinical features onset.

Alternative names

Autoimmune Lymphoproliferative Syndrome, Type Iia; Alps2a Is also known as alps2, autoimmune lymphoproliferative syndrome, type ii.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.

Autoimmune Lymphoproliferative Syndrome, Type Iia; Alps2a Recommended genes panels

Panel Name, Specifity and genes Tested/covered
CASP10 Sequencing.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center (United States).

CASP10
Specificity
100 %
Genes
100 %
Autoimmune Lymphoproliferative Syndrome Panel by next-generation sequencing (NGS).

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center (United States).

FAS, FASLG, CASP10, CASP8, MAGT1, FADD, ITK, KRAS, NRAS
Specificity
12 %
Genes
100 %
Autoimmune Lymphoproliferative Syndrome Deletion/Duplication Panel.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center (United States).

FAS, FASLG, CASP10, CASP8, MAGT1, FADD, ITK, KRAS, NRAS
Specificity
12 %
Genes
100 %
CASP10 Deletion/duplication analysis.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center (United States).

CASP10
Specificity
100 %
Genes
100 %
Tier 2: Hereditary Lymphoma and Immunodeficiency Panel.

By Genetic Services Laboratory University of Chicago (United States).

BLM, SH2D1A, BRCA1, BRCA2, STXBP2, FAS, CD27, FASLG, WAS, IKZF1, CASP10, CARD11, TNFRSF13B, ADA, DOCK8, CTLA4, MAGT1, ITK, NBN, NF1 , (...)

View the complete list with 3 more genes
Specificity
5 %
Genes
100 %
CASP10. Complete sequencing.

By Instituto de Medicina Genomica Instituto de Medicina Genomica (Spain).

CASP10
Specificity
100 %
Genes
100 %
Autoimmune lymphoproliferative syndrome type II (sequence analysis of CASP10 gene).

By CGC Genetics (Portugal).

CASP10
Specificity
100 %
Genes
100 %
Autoimmune Lymphoproliferative Syndrome/ALPS Sequencing Panel with CNV Detection.

By PreventionGenetics PreventionGenetics (United States).

SH2D1A, STAT3, FAS, FASLG, CASP10, CASP8, LRBA, CTLA4, MAGT1, FADD, XIAP, ITK, KRAS, NRAS, PIK3CD, PRKCD
Specificity
7 %
Genes
100 %

You can get up to 14 more panels with our dedicated tool

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Sources and references

You can check the following sources for additional information.

OMIM MESH Rare Disease Symptoms Checker

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