Zinc Deficiency, Transient Neonatal; Tnzd

Description

Transient neonatal zinc deficiency occurs in breast-fed infants as a consequence of low milk zinc concentration in their nursing mothers, which cannot be corrected by maternal zinc supplementation. A large amount of zinc, an essential trace mineral, is required for normal growth particularly in infants, and breast milk normally contains adequate zinc to meet the requirement for infants up to 4 to 6 months of age. Zinc deficiency can lead to dermatitis, alopecia, decreased growth, and impaired immune function. The disorder shows autosomal dominant inheritance with incomplete penetrance (summary by Chowanadisai et al., 2006).Some aspects of TNZD resemble the more severe disorder acrodermatitis enteropathica (AEZ ), an autosomal recessive disorder caused by mutation in the zinc transporter SLC39A4 (OMIM ). However, infants with transient neonatal zinc deficiency do not require zinc supplementation following weaning and have normal zinc absorption, whereas those with AEZ require lifelong zinc supplementation (summary by Chowanadisai et al., 2006).

Clinical Features

Phenotypes and symptoms related to Zinc Deficiency, Transient Neonatal; Tnzd

  • Alopecia
  • Abnormality of the skin
  • Eczema
  • Inflammatory abnormality of the skin
  • Abnormal intestine morphology
  • Abnormality of zinc homeostasis

Incidence and onset information

Not enough data available about incidence and published cases.


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Zinc Deficiency, Transient Neonatal; Tnzd Recommended genes panels

Panel Name, Specifity and genes Tested/covered
SLC30A2 Sequencing.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center in United States.

SLC30A2
Specificity
100 %
Genes
100 %
SLC30A2. Complete sequencing.

By Instituto de Medicina Genomica Instituto de Medicina Genomica in Spain.

SLC30A2
Specificity
100 %
Genes
100 %
Breast milk zinc deficiency: SLC30A2 gene sequence analysis.

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases in Spain.

SLC30A2
Specificity
100 %
Genes
100 %
SLC30A2.

By Fulgent Genetics Fulgent Genetics in United States.

SLC30A2
Specificity
100 %
Genes
100 %
Zinc deficiency, transient neonatal.

By Bioarray in Spain.

SLC30A2
Specificity
100 %
Genes
100 %
ZINC DEFICIENCY IN BREAST MILK.

By Laboratorio de Genetica Clinica SL in Spain.

SLC30A2
Specificity
100 %
Genes
100 %
Zinc Deficiency in Breast Milk , Sequencing SLC30A2 Gene.

By Reference Laboratory Genetics in Spain.

SLC30A2
Specificity
100 %
Genes
100 %

Alternate names

Zinc Deficiency, Transient Neonatal; Tnzd Is also known as zinc deficiency, neonatal, due to low breast milk zinc.



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