Yt Blood Group Antigen

Description

The antibody defining the very common antigen Yt(a) was the cause of a cross-matching difficulty investigated by Eaton et al. (1956). It was presumed to be the result of previous transfusions. Among 1,051 English people, 4 negatives were found. Positives showed 2 grades of strength of reaction; on the assumption that the weaker reactors represented heterozygotes, an estimate of gene frequency simply by counting was possible.Telen et al. (1990) found that the Yt (Cartwright) red cell antigen resided on an unidentified phosphatidylinositol (PI)-linked protein. Telen and Whitsett (1992) identified a patient with the hitherto unreported Yt(a-b-) phenotype in whom studies allowed localization of the Yt antigens to the acetylcholinesterase molecule. Telen and Whitsett (1992) found that binding of antibodies to several membrane proteins including CD55 (OMIM ), CD58 (OMIM ), and CD59 (OMIM ) were normal, whereas 4 monoclonal antibodies to different acetylcholinesterase epitopes reacted only weakly with Yt(a-b-) erythrocytes. In addition, enzymatic assay of acetylcholinesterase activity of Yt(a-b-) erythrocytes demonstrated only 15% of the normal amount of enzyme activity. The use of anti-Yt(a) in radioimmunoprecipitation experiments demonstrated the expected 160 kD of the acetylcholinesterase molecule from normal erythrocyte membrane proteins, but not from Yt(a-b-) erythrocytes. Spring et al. (1992) obtained similar results. Thus, acetylcholinesterase is the PI-linked protein that represents the Yt antigen.

Incidence and onset information

Not enough data available about incidence and published cases.

Genes related to Yt Blood Group Antigen

  • ACHE

Yt Blood Group Antigen Recommended genes panels

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Acetylcholinesterase deficiency

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ACHE

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Alternate names

Yt Blood Group Antigen Is also known as cartwright antigen.

Sources

OMIM

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