Xeroderma Pigmentosum Group C

Description

Xeroderma pigmentosum is a genetically heterogeneous condition characterized by increased sensitivity to ultraviolet (UV) irradiation and increased risk of skin cancer resulting from a defect in DNA repair. XPC is the most common form of XP in the white population, accounting for over a third of all cases in this group (review by Li et al., 1993).For a general discussion of xeroderma pigmentosum, see XPA (OMIM ).

  Similar diseases  

Genes related to Xeroderma Pigmentosum Group C

  • XPC

Clinical Features

Top most frequent phenotypes and symptoms related to Xeroderma Pigmentosum Group C

  • Defective DNA repair after ultraviolet radiation damage
  • Cutaneous melanoma
  • Entropion
  • Squamous cell carcinoma of the skin
  • Poikiloderma
  • Keratitis
  • Telangiectasia
  • Basal cell carcinoma
  • Ectropion
  • Dermal atrophy
View the complete list of symptoms

Incidence and onset information

Not enough data available about incidence and published cases.
— Childhood onset

Xeroderma Pigmentosum Group C Recommended genes panels

Panel Name, Specifity and genes Tested/covered
XPC. Complete sequencing.

XPC
Specificity
100 %
Genes
100 %
Compare panel coverage
Xeroderma pigmentosum disease (sequence analysis of XPC gene).

XPC
Specificity
100 %
Genes
100 %
Compare panel coverage
OncoRisk Plus (NGS panel for 89 genes).

PMS2, SLX4, BLM, DICER1, ERCC2, ERCC4, FANCG, EZH2, FANCL, TSC1, TMEM127, XPA, WRN, CEP57, CYLD, RAD51D, PRF1, PTCH1, RUNX1, BRCA1 , (...)

View the complete list with 69 more genes
Specificity
2 %
Genes
100 %
Compare panel coverage
Xeroderma Pigmentosum via the XPC Gene.

XPC
Specificity
100 %
Genes
100 %
Compare panel coverage
Xeroderma Pigmentosum Sequencing Panel.

ERCC4, ERCC2, XPA, ERCC5, DDB2, POLH, XPC, ERCC3
Specificity
13 %
Genes
100 %
Compare panel coverage
Hereditary Cancer Syndromes - panels.

ATM, BRCA2, BRIP1, BRCA1, CDH1, CDKN1C, CDKN2A, CHEK2, DICER1, GREM1, HNF1A, EGFR, EPCAM, ERCC2, FANCB, FH, MSH6, NBN, PTCH1, SMAD4 , (...)

View the complete list with 80 more genes
Specificity
1 %
Genes
100 %
Compare panel coverage
Xeroderma pigmentosum, group C.

XPC
Specificity
100 %
Genes
100 %
Compare panel coverage
Disorders associated with malignancy Panel.

TSC1, TINF2, NOP10, PMS2, RTEL1, ATM, ERCC2, ERCC8, PTCH1, NF1, WRAP53, DKC1, TERT, SDHB, PTEN, MSH2, PRKAR1A, PDGFRB, RHBDF2, MSH6 , (...)

View the complete list with 25 more genes
Specificity
3 %
Genes
100 %
Compare panel coverage
Xeroderma pigmentosum Panel.

ERCC2, XPA, ERCC4, XPC, ERCC3, DDB2, POLH, ERCC5
Specificity
13 %
Genes
100 %
Compare panel coverage
Ataxia and differential diagnoses Panel.

CYP27A1, POLR3A, CACNA1A, COX20, GMPPB, RARS, APTX, NHLRC1, KIF1C, CLCN2, ATP7B, NEU1, PDP1, SNAP25, NPC1, CA8, RPGRIP1L, SLC17A5, CWF19L1, TDP1 , (...)

View the complete list with 184 more genes
Specificity
1 %
Genes
100 %
Compare panel coverage
Cancer Predisposition.

HRAS, PTEN, WT1, TP53, SMAD4, SDHB, PRKAR1A, PALB2, NF1, MUTYH, EGFR, CHEK2, DICER1, RAD51C, RET, PTCH1, MET, STK11, VHL, NBN , (...)

View the complete list with 69 more genes
Specificity
2 %
Genes
100 %
Compare panel coverage
ONCOLOGY, PANEL.

BRCA1, ATM, BRCA2, BRIP1, CDH1, CDKN1B, DKC1, CDKN2A, CHEK2, GREM1, ERCC2, FANCB, FH, MSH6, NBN, PTCH1, SMAD4, MLH1, MSH2, PRKAR1A , (...)

View the complete list with 60 more genes
Specificity
2 %
Genes
100 %
Compare panel coverage
Inheritest NGS, Comprehensive.

ADA, ADAMTS2, ALPL, AGL, HSD17B4, ATM, ATP7B, BCS1L, BCKDHB, BBS10, BCKDHA, CLN8, CLRN1, CFTR, GAA, GLDC, HADHA, LAMB3, FKTN, GBA , (...)

View the complete list with 120 more genes
Specificity
1 %
Genes
100 %
Compare panel coverage
XPC-related xeroderma pigmentosum.

XPC
Specificity
100 %
Genes
100 %
Compare panel coverage
Hereditary Cancer NGS Panel.

HRAS, WT1, PTPN11, PTEN, RBBP8, BRCA2, PRKAR1A, ERCC4, XRCC3, MSH3, ERCC2, RET, EXO1, APC, CTNNB1, MSH6, PMS2, SDHC, MPL, TP53 , (...)

View the complete list with 92 more genes
Specificity
1 %
Genes
100 %
Compare panel coverage
Xeroderma Pigmentosum NGS Panel.

XPA, ERCC2, ERCC4, ERCC5, DDB2, ERCC3, XPC
Specificity
15 %
Genes
100 %
Compare panel coverage
Xeroderma Pigmentosum NGS Panel.

XPA, ERCC1, ERCC4, ERCC2, XPC, ERCC5, DDB2, ERCC3, POLH
Specificity
12 %
Genes
100 %
Compare panel coverage
XPC.

XPC
Specificity
100 %
Genes
100 %
Compare panel coverage
Comprehensive Cancer Panel.

TMEM127, RET, CDH1, CDKN1B, MPL, XPA, EXO1, MAX, EGLN1, BRIP1, FANCB, KIF1B, CYLD, RBBP8, MUTYH, ERCC4, FANCL, ROBO2, ERCC2, MSH3 , (...)

View the complete list with 104 more genes
Specificity
1 %
Genes
100 %
Compare panel coverage
Hereditary Melanoma and Skin Cancer Panel.

BRCA2, BRCA1, CDKN2A, ERCC2, PTCH1, ERCC4, TP53, WRN, PTEN, XPA, BAP1, CDK4, DDB2, ERCC3, ERCC5, MITF, RB1, SUFU, XPC
Specificity
6 %
Genes
100 %
Compare panel coverage
Xeroderma Pigmentosum Panel.

ERCC2, ERCC4, XPA, DDB2, ERCC3, ERCC5, XPC
Specificity
15 %
Genes
100 %
Compare panel coverage
Comprehensive Hereditary Cancer Panel.

ATM, BRCA2, BRIP1, BRCA1, CDH1, CDKN1B, DKC1, CDKN1C, CDKN2A, CHEK2, DICER1, GREM1, HNF1A, EGFR, EPCAM, ERCC2, EXO1, FANCB, FH, MSH6 , (...)

View the complete list with 96 more genes
Specificity
1 %
Genes
100 %
Compare panel coverage
Xeroderma pigmentosum complementation group C.

XPC
Specificity
100 %
Genes
100 %
Compare panel coverage
CarrierMap.

ADA, GJB2, PUS1, ATP7A, PTS, ADAMTS2, ALPL, AR, ACOX1, RARS2, ABCD1, AGL, AMH, ARG1, BTD, HSD17B4, ATM, ABCA12, ATP7B, ATP6V1B1 , (...)

View the complete list with 281 more genes
Specificity
1 %
Genes
100 %
Compare panel coverage
XERODERMA PIGMENTOSUM.

ERCC1, XPA, ERCC4, ERCC2, ERCC5, DDB2, POLH, XPC, ERCC3
Specificity
12 %
Genes
100 %
Compare panel coverage
Xeroderma Pigmentosum Group C , Sequencing XPC Gene.

XPC
Specificity
100 %
Genes
100 %
Compare panel coverage
152 Integrated Advantage NGS Solid Tumor Panel.

CTNNB1, MAP2K4, XPA, TOP2A, NRAS, PLK1, RAD51C, KRAS, GSTP1, ERCC1, CYP2D6, ABCB1, CDKN1B, MYD88, TSC1, JAK3, AR, ATRX, PDGFRB, MAP2K1 , (...)

View the complete list with 132 more genes
Specificity
1 %
Genes
100 %
Compare panel coverage
Tempus xT assay.

ING1, PRKAR1A, WRN, DDR2, TSC1, IFNAR2, KDM5A, HLA-A, U2AF1, BRIP1, FANCL, PTPN13, STAT5A, TRAF3, CSF1R, HNF1B, MAPK1, SMARCA4, INPP4B, NTRK1 , (...)

View the complete list with 571 more genes
Specificity
1 %
Genes
100 %
Compare panel coverage
Tempus xO assay.

CSK, TWIST1, NUMBL, FBXW11, MSH3, EZH1, PIM1, KLF12, CDX2, ESPL1, SETD1A, HOXC11, INTS12, EIF1AX, NAB1, NRG3, SKI, SF1, PBX3, PAK5 , (...)

View the complete list with 1693 more genes
Specificity
1 %
Genes
100 %
Compare panel coverage

Alternate names

Xeroderma Pigmentosum Group C Is also known as xpcc, xp, group c, xeroderma pigmentosum iii;xp3.

Sources

OMIM

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