Hypertension, and Stage 5 chronic kidney disease

Diseases related with Hypertension and Stage 5 chronic kidney disease

In the following list you will find some of the most common rare diseases related to Hypertension and Stage 5 chronic kidney disease that can help you solving undiagnosed cases.


Top matches:

High match IGA NEPHROPATHY, SUSCEPTIBILITY TO, 3; IGAN3


Related symptoms:

  • Hypertension
  • Proteinuria
  • Stage 5 chronic kidney disease
  • Hematuria
  • Nephropathy


SOURCES: OMIM MENDELIAN

More info about IGA NEPHROPATHY, SUSCEPTIBILITY TO, 3; IGAN3

High match POLYCYSTIC KIDNEY DISEASE 5; PKD5


PKD5, a form of autosomal recessive polycystic kidney disease (ARPKD), is characterized by early childhood onset of progressive renal dysfunction associated with enlarged hyperechogenic kidneys that often results in end-stage renal disease in the second or third decade of life. Arterial hypertension is apparent in early childhood (summary by Lu et al., 2017).For a discussion of genetic heterogeneity of polycystic kidney disease, see PKD1 (OMIM ).

Related symptoms:

  • Hypertension
  • Abnormality of the kidney
  • Stage 5 chronic kidney disease
  • Hepatic fibrosis
  • Polycystic kidney dysplasia


SOURCES: OMIM MENDELIAN

More info about POLYCYSTIC KIDNEY DISEASE 5; PKD5

High match HEMATURIA, BENIGN FAMILIAL; BFH


Benign familial hematuria is an autosomal dominant condition manifest as nonprogressive isolated microscopic hematuria that does not result in renal failure. It is characterized pathologically by thinning of the glomerular basement membrane (GBM), and can be considered the mildest end of the spectrum of renal diseases due to type IV collagen defects of the basement membrane. The most severe end of the spectrum is represented by Alport syndrome ({301050}; {203780}, {104200}), which results in end-stage renal failure and may be associated with hearing loss and ocular anomalies (review by Lemmink et al. (1996)).

HEMATURIA, BENIGN FAMILIAL; BFH Is also known as tmn|thin membrane nephropathy|thin-basement-membrane nephropathy

Related symptoms:

  • Hearing impairment
  • Hypertension
  • Renal insufficiency
  • Proteinuria
  • Stage 5 chronic kidney disease


SOURCES: OMIM MESH MENDELIAN

More info about HEMATURIA, BENIGN FAMILIAL; BFH

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Other less relevant matches:

High match ATYPICAL HEMOLYTIC-UREMIC SYNDROME WITH C3 ANOMALY


ATYPICAL HEMOLYTIC-UREMIC SYNDROME WITH C3 ANOMALY Is also known as ahus with c3 anomaly|hemolytic-uremic syndrome without diarrhea with c3 anomaly|atypical hus with c3 anomaly|d-hus with c3 anomaly|ahus, susceptibility to, 5

Related symptoms:

  • Hypertension
  • Thrombocytopenia
  • Proteinuria
  • Stage 5 chronic kidney disease
  • Hematuria


SOURCES: ORPHANET OMIM MENDELIAN

More info about ATYPICAL HEMOLYTIC-UREMIC SYNDROME WITH C3 ANOMALY

High match FOCAL SEGMENTAL GLOMERULOSCLEROSIS 3, SUSCEPTIBILITY TO; FSGS3


Focal segmental glomerulosclerosis (FSGS) is a pathologic entity associated clinically with proteinuria, the nephrotic syndrome (NPHS), and progressive loss of renal function. It is a common cause of end-stage renal disease (ESRD) (Meyrier, 2005).For a general phenotypic description and a discussion of genetic heterogeneity of focal segmental glomerulosclerosis and nephrotic syndrome, see FSGS1 (OMIM ).

FOCAL SEGMENTAL GLOMERULOSCLEROSIS 3, SUSCEPTIBILITY TO; FSGS3 Is also known as glomerulosclerosis, focal segmental, 3, susceptibility to

Related symptoms:

  • Failure to thrive
  • Anemia
  • Hypertension
  • Renal insufficiency
  • Proteinuria


SOURCES: OMIM MENDELIAN

More info about FOCAL SEGMENTAL GLOMERULOSCLEROSIS 3, SUSCEPTIBILITY TO; FSGS3

High match POLYCYSTIC KIDNEY DISEASE 6 WITH OR WITHOUT POLYCYSTIC LIVER DISEASE; PKD6


Polycystic kidney disease-6 is an autosomal dominant renal disease characterized by the development of multiple small renal cysts and progression to renal insufficiency or end-stage renal disease (ESRD) most often after the sixth decade. The cysts are generally small (less than 1 to 3 cm) and the kidneys are not massively enlarged. Some patients may have evidence of chronic interstitial fibrosis and about half develop liver cysts (summary by Cornec-Le Gall et al., 2018).For a discussion of genetic heterogeneity of polycystic kidney disease, see PKD1 (OMIM ).

Related symptoms:

  • Hypertension
  • Renal insufficiency
  • Abnormality of the kidney
  • Stage 5 chronic kidney disease
  • Renal cyst


SOURCES: OMIM MENDELIAN

More info about POLYCYSTIC KIDNEY DISEASE 6 WITH OR WITHOUT POLYCYSTIC LIVER DISEASE; PKD6

High match FOCAL SEGMENTAL GLOMERULOSCLEROSIS 5; FSGS5


Focal segmental glomerulosclerosis (FSGS) is a pathologic entity associated clinically with proteinuria, the nephrotic syndrome (NPHS), and progressive loss of renal function. It is a common cause of end-stage renal disease (ESRD) (Meyrier, 2005).Dominant intermediate Charcot-Marie-Tooth disease E and focal segmental glomerulonephritis (CMTDIE ) is also caused by heterozygous mutation in the INF2 gene.For a general phenotypic description and a discussion of genetic heterogeneity of focal segmental glomerulosclerosis and nephrotic syndrome, see FSGS1 (OMIM ).

FOCAL SEGMENTAL GLOMERULOSCLEROSIS 5; FSGS5 Is also known as glomerulosclerosis, focal segmental, 5

Related symptoms:

  • Hypertension
  • Edema
  • Proteinuria
  • Stage 5 chronic kidney disease
  • Hematuria


SOURCES: MESH OMIM MENDELIAN

More info about FOCAL SEGMENTAL GLOMERULOSCLEROSIS 5; FSGS5

High match FAMILIAL JUVENILE HYPERURICEMIC NEPHROPATHY TYPE 1


Familial juvenile hyperuricemic nephropathy type 1 (FJHN1) is a rare kidney disorder characterized by hyperuricemia, progressive nephropathy, and gout occurring at an early age.

FAMILIAL JUVENILE HYPERURICEMIC NEPHROPATHY TYPE 1 Is also known as familial nephropathy with gout|umod-associated fjhn|hnfj|familial juvenile hyperuricemic nephropathy|gouty nephropathy, familial juvenile|familial juvenile gouty nephropathy|fjhn type 1|fjhn|hyperuricemic nephropathy, familial juvenile|umod-associated fam

Related symptoms:

  • Hypertension
  • Renal insufficiency
  • Arthritis
  • Abnormality of the kidney
  • Stage 5 chronic kidney disease


SOURCES: OMIM ORPHANET MENDELIAN

More info about FAMILIAL JUVENILE HYPERURICEMIC NEPHROPATHY TYPE 1

High match LIDDLE SYNDROME 1; LIDLS1


Liddle syndrome is an autosomal dominant disorder characterized by early-onset salt-sensitive hypertension, hypokalemia, metabolic alkalosis, and suppression of plasma renin activity and aldosterone secretion (summary by Yang et al., 2014). Genetic Heterogeneity of Liddle SyndromeLiddle syndrome-2 (OMIM ) is caused by mutation in the SCNN1G gene (OMIM ), which encodes the ENaC gamma subunit. Liddle syndrome-3 (OMIM ) is caused by mutation in the SCNN1A gene (OMIM ), which encodes the ENaC alpha subunit.Hanukoglu and Hanukoglu (2016) provided a detailed review of the ENaC gene family, including structure, function, tissue distribution, and associated inherited diseases.

LIDDLE SYNDROME 1; LIDLS1 Is also known as lidls|liddle syndrome|pseudoaldosteronism|pseudohyperaldosteronism

Related symptoms:

  • Hypertension
  • Renal insufficiency
  • Stroke
  • Stage 5 chronic kidney disease
  • Abnormality of the cardiovascular system


SOURCES: OMIM MENDELIAN

More info about LIDDLE SYNDROME 1; LIDLS1

High match IMMUNOGLOBULIN-MEDIATED MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS


Nephrotic syndrome type 7 is an autosomal recessive renal disease characterized by onset of nephrotic syndrome with proteinuria usually in the first decade of life. The disorder is progressive, and some patients develop end-stage renal disease within several years. Renal biopsy typically shows membranoproliferative glomerulonephritis. Some patients may benefit from immunosuppressive therapy (summary by Ozaltin et al., 2013).Atypical hemolytic uremic syndrome-7 is characterized by acute onset in the first year of life of microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. After the acute episode, most patients develop chronic renal insufficiency. Unlike other genetic forms of aHUS, AHUS7 is not related to abnormal activation of the complement system (summary by Lemaire et al., 2013).For a general phenotypic description and a discussion of genetic heterogeneity of nephrotic syndrome, see NPHS1 (OMIM ).For a general phenotypic description and a discussion of genetic heterogeneity of aHUS, see AHUS1 (OMIM ).

IMMUNOGLOBULIN-MEDIATED MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS Is also known as ig-mediated mpgn|immunoglobulin-mediated mpgn|ig-mediated membranoproliferative glomerulonephritis|nephrotic syndrome, type 7, with membranoproliferative glomerulonephritis

Related symptoms:

  • Anemia
  • Hypertension
  • Renal insufficiency
  • Thrombocytopenia
  • Proteinuria


SOURCES: ORPHANET OMIM MENDELIAN

More info about IMMUNOGLOBULIN-MEDIATED MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS

Top 5 symptoms//phenotypes associated to Hypertension and Stage 5 chronic kidney disease

Symptoms // Phenotype % cases
Renal insufficiency Common - Between 50% and 80% cases
Proteinuria Common - Between 50% and 80% cases
Hematuria Uncommon - Between 30% and 50% cases
Microscopic hematuria Uncommon - Between 30% and 50% cases
Focal segmental glomerulosclerosis Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Hypertension and Stage 5 chronic kidney disease. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Nephrotic syndrome Glomerulosclerosis Abnormality of the kidney Nephropathy

Rare Symptoms - Less than 30% cases


Renal cyst Hemolytic-uremic syndrome Chronic kidney disease Glomerulonephritis Anemia Microangiopathic hemolytic anemia Gout Elevated serum creatinine Acute kidney injury Thrombocytopenia Hyperechogenic kidneys Polycystic kidney dysplasia IgA deposition in the glomerulus Decreased circulating renin level Hypokalemia Hyperaldosteronism Alkalosis Metabolic alkalosis Decreased circulating aldosterone level Hypokalemic metabolic alkalosis Pseudohypoaldosteronism Hypokalemic alkalosis Abnormality of the cardiovascular system Nephrosclerosis Hemolytic anemia Meningitis Glomerulopathy Membranoproliferative glomerulonephritis Myocardial infarction Tubulointerstitial nephritis Stroke Hepatic cysts Anuria Failure to thrive Thin glomerular basement membrane Hearing impairment Hepatic fibrosis Mesangial hypercellularity Decreased glomerular filtration rate Multiple glomerular cysts Edema Hypoalbuminemia Arthritis Nephritis Hyperuricemia Increased blood urea nitrogen Tubular atrophy Thickening of the glomerular basement membrane



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