Nail Disorder, Nonsyndromic Congenital, 3; Ndnc3
Description
A white appearance of the nails can result from whitening of the nail plate (true leukonychia), the nail bed (pseudoleukonychia), or neither (apparent leukonychia), and can be due to a variety of factors including infectious, metabolic, or systemic diseases, trauma, or drugs. One of the rare causes of whitening of the nail plate is hereditary leukonychia (summary by Kiuru et al., 2011). Leukonychia may involve all of the nail (leukonychia totalis) or only part of the nail (leukonychia partialis), or can appear as one or more transverse bands (leukonychia striata) or white spots (leukonychia punctata).For a list of other nonsyndromic congenital nail disorders and a discussion of genetic heterogeneity, see NDNC1 (OMIM ).
Genes related to Nail Disorder, Nonsyndromic Congenital, 3; Ndnc3
- PLCD1
Clinical Features
Top most frequent phenotypes and symptoms related to Nail Disorder, Nonsyndromic Congenital, 3; Ndnc3
- Pain
- Diabetes mellitus
- Photophobia
- Carious teeth
- Palmoplantar keratoderma
- Ectodermal dysplasia
- Type II diabetes mellitus
- Nephrolithiasis
- Abnormality of the fingernails
- Psoriasiform dermatitis
Incidence and onset information
— Not enough data available about incidence and published cases.
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Nail Disorder, Nonsyndromic Congenital, 3; Ndnc3 Recommended genes panels
| Panel Name, Specifity and genes Tested/covered |
|---|
|
PLCD1.
By Fulgent Genetics Fulgent Genetics in United States.
PLCD1
Specificity
100 %
Genes
100 % |
Alternate names
Nail Disorder, Nonsyndromic Congenital, 3; Ndnc3 Is also known as leukonychia totalis and/or partialis, porcelain nails;.
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