Lymphoma, Hodgkin, Classic; Chl
Description
Classic Hodgkin lymphoma is a lymph node cancer of germinal center B-cell origin. Hodgkin lymphoma tumors consist of a minority of malignant cells, known as 'Reed-Sternberg' (RS) cells, mixed with reactive lymphocytes and other benign inflammatory cells. A defining feature of RS cells is the presence of 2 nuclei (summary by Salipante et al., 2009).
Clinical Features
Top most frequent phenotypes and symptoms related to Lymphoma, Hodgkin, Classic; Chl
- Ataxia
- Neoplasm
- Peripheral neuropathy
- Hepatomegaly
- Fever
- Fatigue
- Respiratory insufficiency
- Splenomegaly
- Hyperhidrosis
- Weight loss
And another 20 symptoms. If you need more information about this disease we can help you.
Incidence and onset information
— Based on the latest data available LYMPHOMA, HODGKIN, CLASSIC; CHL have a estimated incidence of 2.38 per 100k worldwide.— No data available about the known clinical features onset.
Alternative names
Lymphoma, Hodgkin, Classic; Chl Is also known as hodgkin disease.
Researches and researchers
Doctors, researchs, and experts related to Lymphoma, Hodgkin, Classic; Chl extracted from public data.
Lymphoma, Hodgkin, Classic; Chl Experts map
Current Researchs and researchers
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Principal investigator of clinical trial - Investigator of clinical trial - Coordinator of research network
PIERRE-BENITE — Pr Bertrand COIFFIER
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Institution/s:
— CHU de Lyon HCL - GH Sud
— CHU de Lyon HCL - GH Sud -
Research area/topic::
Groupe d'étude des lymphomes de l'adulte
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Institution/s:
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Principal investigator of clinical trial - Coordinator of research network PIERRE-BENITE — Pr Gilles SALLES
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Institution/s:
— CHU de Lyon HCL - GH Sud
— CHU de Lyon HCL - GH Sud -
Research area/topic::
Groupe d'étude des lymphomes de l'adulte
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Institution/s:
Lymphoma, Hodgkin, Classic; Chl Recommended genes panels
| Panel Name, Specifity and genes Tested/covered |
|---|
 Tier 1: Hereditary Lymphoma and Immunodeficiency Panel.
By Genetic Services Laboratory University of Chicago (United States).
TP53, POT1, TERF2IP, ACD, KLHDC8B, MLH1, MSH2, MSH6, NPAT, PMS2
Specificity
10 %
Genes
100 % |
|
KLHDC8B.
By Fulgent Genetics Fulgent Genetics (United States).
KLHDC8B
Specificity
100 %
Genes
100 % |
 CEN4GEN Comprehensive Hereditary Cancer Syndrome: Gene sequencing Panel.
By CEN4GEN Institute for Genomics and Molecular Diagnostics (Canada).
RNASEL, RUNX1, BLM, SDHA, SDHB, SDHC, SDHD, BMPR1A, BRCA1, BRCA2, SMARCA4, SMARCB1, STK11, BUB1B, EPCAM, TERT, TGFBR1, TINF2, TP53, TSC1 , (...)
View the complete list with 122 more genes
Specificity
1 %
Genes
100 % |
You can get up to -5 more panels with our dedicated tool
Learn moreSources and references
You can check the following sources for additional information.
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