ZNF141 gene related symptoms and diseases

All the information presented here about the ZNF141 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: OMIM,ORPHANET,HGNC,NCBIGENE, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to ZNF141 gene

Symptoms // Phenotype % Cases
Postaxial hand polydactyly Very Common - Between 80% and 100% cases
Syndactyly Uncommon - Between 30% and 50% cases
Polydactyly Uncommon - Between 30% and 50% cases
Abnormality of the foot Uncommon - Between 30% and 50% cases
Postaxial polydactyly Uncommon - Between 30% and 50% cases

Other less frequent symptoms and clinical features

Patients with ZNF141 gene alterations may also develop some of the following symptoms and phenotypes:
  • Not very common - Between 30% and 50% cases

  • Broad thumb
  • Preaxial polydactyly
  • Triphalangeal thumb
  • Abnormal facial shape
  • Hyperhidrosis
  • Broad phalanges of the 5th finger
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Rare diseases associated to ZNF141 gene

Here you will find a list of rare diseases related to the ZNF141. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


POSTAXIAL POLYDACTYLY TYPE A


Alternate names

POSTAXIAL POLYDACTYLY TYPE A Is also known as postaxial polydactyly, type a, papa, polydactyly, postaxial

Description

Polydactyly refers to the occurrence of supernumerary digits and is the most frequent of congenital hand and foot deformities. Based on the location of the extra digits, polydactyly can be classified into preaxial, involving the thumb or great toe; postaxial, affecting the fifth digit; and central, involving the 3 central digits. Postaxial polydactyly (PAP) is further subclassified into 2 types: in type A, a well-formed extra digit articulates with the fifth or a sixth metacarpal, whereas in type B, a rudimentary, poorly developed extra digit is present (summary by Umm-e-Kalsoom et al., 2012). Genetic Heterogeneity of Postaxial PolydactylyOther forms of postaxial polydactyly type A include PAPA2 (OMIM ) on chromosome 13q21; PAPA3 (OMIM ) on chromosome 19p13; PAPA4 (OMIM ) on chromosome 7q22; PAPA5 (OMIM ) on chromosome 13q13; PAPA6 (OMIM ), caused by mutation in the ZNF141 gene (OMIM ) on chromosome 4p16; PAPA7 (OMIM ), caused by mutation in the IQCE gene (OMIM ) on chromosome 7p22; and PAPA8 (OMIM ), caused by mutation in the GLI1 gene (OMIM ) on chromosome 12q13.

Most common symptoms of POSTAXIAL POLYDACTYLY TYPE A

  • Syndactyly
  • Polydactyly
  • Abnormality of the foot
  • Postaxial polydactyly
  • Postaxial hand polydactyly


More info about POSTAXIAL POLYDACTYLY TYPE A

SOURCES: OMIM ORPHANET

POLYDACTYLY, POSTAXIAL, TYPE A6; PAPA6


Most common symptoms of POLYDACTYLY, POSTAXIAL, TYPE A6; PAPA6

  • Abnormal facial shape
  • Hyperhidrosis
  • Postaxial hand polydactyly
  • Broad phalanges of the 5th finger


More info about POLYDACTYLY, POSTAXIAL, TYPE A6; PAPA6

SOURCES: OMIM


Potential gene panels for ZNF141 gene

ZNF141 Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the ZNF141 gene.

More info about this panel


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