NANOS1 gene related symptoms and diseases

All the information presented here about the NANOS1 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,ORPHANET,HGNC,OMIM, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to NANOS1 gene

Symptoms // Phenotype % Cases
Azoospermia Very Common - Between 80% and 100% cases
Infertility Uncommon - Between 30% and 50% cases
Abnormal male germ cell morphology Uncommon - Between 30% and 50% cases
Decreased testicular size Uncommon - Between 30% and 50% cases
Increased circulating gonadotropin level Uncommon - Between 30% and 50% cases

Other less frequent symptoms and clinical features

Patients with NANOS1 gene alterations may also develop some of the following symptoms and phenotypes:
  • Not very common - Between 30% and 50% cases

  • Abnormal spermatogenesis
  • Obstructive azoospermia
  • Non-obstructive azoospermia
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Rare diseases associated to NANOS1 gene

Here you will find a list of rare diseases related to the NANOS1. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


SPERMATOGENIC FAILURE 12; SPGF12


Most common symptoms of SPERMATOGENIC FAILURE 12; SPGF12

  • Infertility
  • Azoospermia
  • Abnormal male germ cell morphology


More info about SPERMATOGENIC FAILURE 12; SPGF12

SOURCES: OMIM

MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION


Description

Male infertility with azoospermia or oligospermia due to single gene mutation is a rare, genetic male infertility due to sperm disorder characterized by the absence of a measurable amount of spermatozoa in the ejaculate (azoospermia), or a number of sperm in the ejaculate inferior to 15 million/mL (oligozoospermia), resulting from a mutation in a single gene known to cause azoo- or oligo-spermia. Sperm morphology may be normal.

Most common symptoms of MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION

  • Decreased testicular size
  • Azoospermia
  • Increased circulating gonadotropin level
  • Abnormal spermatogenesis
  • Obstructive azoospermia


More info about MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION

SOURCES: ORPHANET


Potential gene panels for NANOS1 gene

Spermatogenic failure 12 (SPGF12, sequence analysis of NANOS1 gene) Panel

Portugal.

By CGC Genetics

This panel specifically test the NANOS1 gene.

More info about this panel

Male Infertility Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Male Infertility Sequencing Panel with CNV Detection that also includes the following genes: SEMA3A SEMA3E FOXL2 BRDT SOX10 SOX2 SOX3 SOX9 SRA1 SRD5A2

More info about this panel

Disorders of Sex Development (DSD) and Infertility Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Disorders of Sex Development (DSD) and Infertility Sequencing Panel with CNV Detection that also includes the following genes: ROR2 SALL1 BMP15 BMP4 SEMA3A SEMA3E BMP7 FOXL2 BRDT SOS1

More info about this panel

Oligo-astheno-teratozoospermia Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the NANOS1 gene.

More info about this panel


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