MLH3 gene related symptoms and diseases
All the information presented here about the MLH3 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: HGNC,NCBIGENE,ORPHANET,OMIM, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to MLH3 gene
| Symptoms // Phenotype | % Cases |
|---|---|
| Neoplasm | Uncommon - Between 30% and 50% cases |
| Hereditary nonpolyposis colorectal carcinoma | Uncommon - Between 30% and 50% cases |
| Carcinoma | Uncommon - Between 30% and 50% cases |
| Leiomyosarcoma | Uncommon - Between 30% and 50% cases |
| Colon cancer | Uncommon - Between 30% and 50% cases |
Other less frequent symptoms and clinical features
Patients with MLH3 gene alterations may also develop some of the following symptoms and phenotypes:Not very common - Between 30% and 50% cases
- Endometrial carcinoma
Rarely - Less than 30% cases
- Neoplasm of the pancreas
- Pituitary adenoma
- Intestinal polyposis
- Agnosia
- Dysgraphia
- Hepatocellular carcinoma
- Amaurosis fugax
And 53 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to MLH3 gene
Here you will find a list of rare diseases related to the MLH3. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
LYNCH SYNDROME
Alternate names
LYNCH SYNDROME Is also known as coca2, colon cancer, familial nonpolyposis, type 2, fcc2
Most common symptoms of LYNCH SYNDROME
- Seizures
- Neoplasm
- Muscular hypotonia
- Flexion contracture
- Visual impairment
More info about LYNCH SYNDROME
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 7; HNPCC7
Most common symptoms of COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 7; HNPCC7
- Hereditary nonpolyposis colorectal carcinoma
More info about COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 7; HNPCC7
COLORECTAL CANCER; CRC
Alternate names
COLORECTAL CANCER; CRC Is also known as colon cancer
Description
Colorectal cancer is a heterogeneous disease that is common in both men and women. In addition to lifestyle and environmental risk factors, gene defects can contribute to an inherited predisposition to CRC. CRC is caused by changes in different molecular pathogenic pathways, such as chromosomal instability, CpG island methylator phenotype, and microsatellite instability. Chromosome instability is the most common alteration and is present in almost 85% of all cases (review by Schweiger et al., 2013).
Most common symptoms of COLORECTAL CANCER; CRC
- Neoplasm
- Carcinoma
- Oligodontia
- Colon cancer
- Colitis
More info about COLORECTAL CANCER; CRC
SOURCES: OMIM
ENDOMETRIAL CANCER
Description
Cancer that forms in the tissue lining the uterus (the small, hollow, pear-shaped organ in a woman's pelvis in which a fetus develops). Most endometrial cancers are adenocarcinomas (cancers that begin in cells that make and release mucus and other fluids).
Most common symptoms of ENDOMETRIAL CANCER
- Endometrial carcinoma
More info about ENDOMETRIAL CANCER
SOURCES: OMIM
Search interest in MLH3
Potential gene panels for MLH3 gene
Nonpolyposis hereditary colorectal cancer (sequence analysis of MLH3 gene) Panel
Portugal.
By CGC Genetics
This panel specifically test the MLH3 gene.
More info about this panel Portugal.
Hereditary colon cancer (panel NGS of 21 genes) Panel
Portugal.
By CGC Genetics Hereditary colon cancer (panel NGS of 21 genes) that also includes the following genes: BMPR1A STK11 EPCAM TGFBR2 TP53 CDH1 GALNT12 APC SMAD4 MLH1
More info about this panel Portugal.
Hereditary nonpolyposis colorectal cancer (metilation analysis and deletions/duplications analysis of MLH1, MLH3, MSH2, MSH3, MSH6, PMS2 and MGMT by MS-MLPA) Panel
Portugal.
By CGC Genetics Hereditary nonpolyposis colorectal cancer (metilation analysis and deletions/duplications analysis of MLH1, MLH3, MSH2, MSH3, MSH6, PMS2 and MGMT by MS-MLPA) that also includes the following genes: MLH1 MLH3 MSH2 MSH3 MSH6 PMS2
More info about this panel Portugal.
Hereditary nonpolyposis colorectal cancer (metilation analysis and deletions/duplications analysis of MLH1, MLH3, MSH2, MSH3, MSH6, PMS2 and MGMT by MS-MLPA) Panel
Portugal.
By CGC Genetics Hereditary nonpolyposis colorectal cancer (metilation analysis and deletions/duplications analysis of MLH1, MLH3, MSH2, MSH3, MSH6, PMS2 and MGMT by MS-MLPA) that also includes the following genes: MLH1 MLH3 MSH2 MSH3 MSH6 PMS2
More info about this panel Portugal.
Hereditary colon cancer (panel NGS of 21 genes) Panel
Portugal.
By CGC Genetics Hereditary colon cancer (panel NGS of 21 genes) that also includes the following genes: BMPR1A STK11 EPCAM TGFBR2 TP53 CDH1 GALNT12 APC SMAD4 MLH1
More info about this panel Portugal.
Hereditary colorectal cancer Panel
Poland.
By Laboratory of Genetics BioTe21 Adam Master Hereditary colorectal cancer that also includes the following genes: BMPR1A STK11 APC SMAD4 MLH1 MLH3 MSH2 MSH6 MUTYH PMS2
More info about this panel Poland.
Cancer Sequencing Panel with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics Cancer Sequencing Panel with CNV Detection that also includes the following genes: RUNX1 BLM SDHA SDHB SDHC SDHD BMPR1A BRCA1 BRCA2 SMARCA4
More info about this panel United States.
Colorectal Cancer Sequencing Panel with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics Colorectal Cancer Sequencing Panel with CNV Detection that also includes the following genes: BMPR1A STK11 EPCAM TP53 CDH1 GALNT12 GREM1 APC SMAD4 MLH1
More info about this panel United States.
Lynch Syndrome via MLH3 Gene Sequencing with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics
This panel specifically test the MLH3 gene.
More info about this panel United States.
Hnpcc Deep Intronic Panel
Germany.
By MGZ Medical Genetics Center Hnpcc Deep Intronic that also includes the following genes: EPCAM MLH1 MLH3 MSH2 MSH3 MSH6 PMS1 PMS2
More info about this panel Germany.
Colorectal cancer, hereditary nonpolyposis type 7 Panel
Germany.
By Centogene AG - the Rare Disease Company
This panel specifically test the MLH3 gene.
More info about this panel Germany.
MMR genes methylation analysis Panel
Germany.
By Centogene AG - the Rare Disease Company MMR genes methylation analysis that also includes the following genes: MGMT MLH1 MLH3 MSH2 MSH3 MSH6 PMS2
More info about this panel Germany.
COLON, BREAST AND OVARIAN CANCER Panel
Spain.
By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases COLON, BREAST AND OVARIAN CANCER that also includes the following genes: BMPR1A BRCA1 BRCA2 STK11 EPCAM TP53 XRCC2 CDH1 BRIP1 PALB2
More info about this panel Spain.
MLH3 Panel
United States.
By Fulgent Genetics Fulgent Genetics
This panel specifically test the MLH3 gene.
More info about this panel United States.
Colorectal Cancer Comprehensive Panel Panel
United States.
By Fulgent Genetics Fulgent Genetics Colorectal Cancer Comprehensive Panel that also includes the following genes: BMPR1A STK11 EPCAM TP53 GALNT12 GREM1 APC SMAD4 MLH1 MLH3
More info about this panel United States.
Comprehensive Hereditary Cancer Panel Panel
Finland.
By Blueprint Genetics Comprehensive Hereditary Cancer Panel that also includes the following genes: RIT1 RRAS RUNX1 BLM SDHA SDHB SDHC SDHD BMPR1A BRAF
More info about this panel Finland.
COLORECTAL CANCER, NONPOLYPOSIC (LYNCH SYNDROME) Panel
Spain.
By Laboratorio de Genetica Clinica SL COLORECTAL CANCER, NONPOLYPOSIC (LYNCH SYNDROME) that also includes the following genes: MLH1 MLH3 MSH2 MSH6 PMS1 PMS2
More info about this panel Spain.
COLORECTAL CANCER HEREDITARY NGS PANEL Panel
Spain.
By Laboratorio de Genetica Clinica SL COLORECTAL CANCER HEREDITARY NGS PANEL that also includes the following genes: BMPR1A STK11 EPCAM TGFBR2 TP53 GREM1 APC SMAD4 MLH1 MLH3
More info about this panel Spain.
BREAST AND OVARIAN CANCER NGS PANEL Panel
Spain.
By Laboratorio de Genetica Clinica SL BREAST AND OVARIAN CANCER NGS PANEL that also includes the following genes: BLM BRCA1 BRCA2 STK11 EPCAM TP53 WRN CDH1 PSMC3IP TNFRSF13B
More info about this panel Spain.
COLORECTAL CANCER, NONPOLYPOSIC (LYNCH SYNDROME) NGS PANEL Panel
Spain.
By Laboratorio de Genetica Clinica SL COLORECTAL CANCER, NONPOLYPOSIC (LYNCH SYNDROME) NGS PANEL that also includes the following genes: EPCAM TGFBR2 MLH1 MLH3 MSH2 MSH6 PMS1 PMS2
More info about this panel Spain.
Hereditary Non-Polyposis Colon Cancer , Sequencing MLH3 Gene Panel
Spain.
By Reference Laboratory Genetics
This panel specifically test the MLH3 gene.
More info about this panel Spain.
Familial Pancreatic Cancer , Panel Massive Sequencing (NGS) 16 Genes Panel
Spain.
By Reference Laboratory Genetics Familial Pancreatic Cancer , Panel Massive Sequencing (NGS) 16 Genes that also includes the following genes: BRCA1 BRCA2 STK11 TGFBR2 TP53 CDKN2A PALB2 APC KRAS SMAD4
More info about this panel Spain.
Tempus xT assay Panel
United States.
By Tempus Labs, Inc. Tempus xT assay that also includes the following genes: BCL6 RIT1 BCL7A BCR ROS1 RPL5 RPS15 RPS6KB1 RUNX1 RXRA
More info about this panel United States.
Tempus xO assay Panel
United States.
By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2
More info about this panel United States.
CEN4GEN Comprehensive Hereditary Cancer Syndrome: Gene sequencing Panel Panel
Canada.
By CEN4GEN Institute for Genomics and Molecular Diagnostics CEN4GEN Comprehensive Hereditary Cancer Syndrome: Gene sequencing Panel that also includes the following genes: RNASEL RUNX1 BLM SDHA SDHB SDHC SDHD BMPR1A BRCA1 BRCA2
More info about this panel Canada.
PrimBio Colorectal Cancer Panel Panel
United States.
By PrimBio Research Institute PrimBio Research Institute PrimBio Colorectal Cancer Panel that also includes the following genes: BLM BMPR1A SCG5 BRAF BRCA1 STK11 BUB1B EPCAM TCF7L2 TGFBR2
More info about this panel United States.
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