MAPK10 gene related symptoms and diseases

All the information presented here about the MAPK10 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: HGNC,OMIM,NCBIGENE,ORPHANET, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to MAPK10 gene

Symptoms // Phenotype % Cases
Intellectual disability Very Common - Between 80% and 100% cases
Relative macrocephaly Very Common - Between 80% and 100% cases
Generalized tonic-clonic seizures Very Common - Between 80% and 100% cases
Falls Very Common - Between 80% and 100% cases
Generalized myoclonic seizures Very Common - Between 80% and 100% cases

Other less frequent symptoms and clinical features

Patients with MAPK10 gene alterations may also develop some of the following symptoms and phenotypes:
  • Commonly - More than 50% cases

  • Focal-onset seizure
  • Epileptic encephalopathy
  • Gingival overgrowth
  • Intellectual disability, progressive
  • Tented upper lip vermilion
  • Atonic seizures
  • Mental deterioration
  • Abnormality of the periventricular white matter

And 31 more phenotypes, you can get all of them using our tools for rare diseases.

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Rare diseases associated to MAPK10 gene

Here you will find a list of rare diseases related to the MAPK10. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


LENNOX-GASTAUT SYNDROME


Description

Lennox-Gastaut syndrome (LGS) belongs to the group of severe childhood epileptic encephalopathies.

Most common symptoms of LENNOX-GASTAUT SYNDROME

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Ptosis
  • Low-set ears


More info about LENNOX-GASTAUT SYNDROME

SOURCES: OMIM ORPHANET


Potential gene panels for MAPK10 gene

Ataxia Exome Panel Panel

United States.

By Genetic Services Laboratory University of Chicago Ataxia Exome Panel that also includes the following genes: BCS1L RTN2 SACS SCN1A SCN2A SCN8A SCO1 SDHA SDHD SLC16A2

More info about this panel

MAPK10. Complete sequencing Panel

Spain.

By Instituto de Medicina Genomica Instituto de Medicina Genomica

This panel specifically test the MAPK10 gene.

More info about this panel

Epileptic encephalopathy, Lennox-Gastaut type (sequence analysis MAPK10 gene) Panel

Portugal.

By CGC Genetics

This panel specifically test the MAPK10 gene.

More info about this panel

Epileptic encephalopathy (NGS panel for 67 genes) Panel

Portugal.

By CGC Genetics Epileptic encephalopathy (NGS panel for 67 genes) that also includes the following genes: SCN1A SCN1B SCN2A SCN8A SCN9A ST3GAL3 SLC2A1 SLC9A6 SPTAN1 CDKL5

More info about this panel

Epileptic encephalopathy panel Panel

Netherlands.

By Genome Diagnostics Laboratory University Medical Center Utrecht Epileptic encephalopathy panel that also includes the following genes: SCN1A SCN1B SCN2A SCN8A SCN9A SLC2A1 SPTAN1 CDKL5 STXBP1 SYNGAP1

More info about this panel

Epileptic encephalopathy, Lennox-Gastaut type Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the MAPK10 gene.

More info about this panel

AllNeuro panel Panel

Germany.

By Centogene AG - the Rare Disease Company AllNeuro panel that also includes the following genes: BCS1L ROR2 RPL10 BDNF RPS6KA3 RTN2 RYR1 SACS BIN1 SBF1

More info about this panel

Epileptic encephalopathy, Lennox Gastaut type Panel

Austria.

By Praxis fuer Humangenetik Wien

This panel specifically test the MAPK10 gene.

More info about this panel

Epileptic encephalopathy, Lennox Gastaut type Panel

Slovakia.

By MedGene

This panel specifically test the MAPK10 gene.

More info about this panel

Epileptic encephalopathies Panel

Spain.

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases Epileptic encephalopathies that also includes the following genes: SCN1A SCN2A SCN8A ST3GAL3 SLC2A1 SPTAN1 CDKL5 STXBP1 TREX1 WWOX

More info about this panel

Neurology: Sequencing Panel Panel

United States.

By EGL Genetic Diagnostics Eurofins Clinical Diagnostics Neurology: Sequencing Panel that also includes the following genes: SCN1A SCN1B SCN2A SCN8A SCN9A SHH ST3GAL3 ST3GAL5 STIL SIX3

More info about this panel

Epilepsy NGS Panel Panel

United States.

By Fulgent Genetics Fulgent Genetics Epilepsy NGS Panel that also includes the following genes: BCS1L SCN10A SCN1A SCN1B SCN2A SCN2B SCN3A SCN4A SCN4B SCN5A

More info about this panel

Essential Epilepsy NGS Panel Panel

United States.

By Fulgent Genetics Fulgent Genetics Essential Epilepsy NGS Panel that also includes the following genes: SCN1A SCN1B SCN2A SCN8A SCN9A ST3GAL3 ST3GAL5 SLC2A1 SLC35A2 SLC9A6

More info about this panel

Comprehensive Epilepsy NGS Panel Panel

United States.

By Fulgent Genetics Fulgent Genetics Comprehensive Epilepsy NGS Panel that also includes the following genes: BCS1L RYR3 SCN10A SCN1A SCN1B SCN2A SCN2B SCN3A SCN4A SCN4B

More info about this panel

MAPK10 Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the MAPK10 gene.

More info about this panel

Lennox-Gastaut syndrome Panel

Spain.

By Bioarray

This panel specifically test the MAPK10 gene.

More info about this panel

Lennox-Gastaut Syndrome, Sequencing MAPK10 Gene Panel

Spain.

By Reference Laboratory Genetics

This panel specifically test the MAPK10 gene.

More info about this panel

Tempus xO assay Panel

United States.

By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2

More info about this panel


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