MAP3K6 gene related symptoms and diseases

All the information presented here about the MAP3K6 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,ORPHANET,OMIM,HGNC, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to MAP3K6 gene

Symptoms // Phenotype % Cases
Neoplasm Very Common - Between 80% and 100% cases
Cleft palate Very Common - Between 80% and 100% cases
Carcinoma Very Common - Between 80% and 100% cases
Cleft lip Very Common - Between 80% and 100% cases
Cleft upper lip Very Common - Between 80% and 100% cases

Other less frequent symptoms and clinical features

Patients with MAP3K6 gene alterations may also develop some of the following symptoms and phenotypes:
  • Commonly - More than 50% cases

  • Oral cleft
  • Breast carcinoma
  • Stomach cancer
  • Chronic atrophic gastritis
  • Helicobacter pylori infection
  • Acrania
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Rare diseases associated to MAP3K6 gene

Here you will find a list of rare diseases related to the MAP3K6. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


HEREDITARY DIFFUSE GASTRIC CANCER


Alternate names

HEREDITARY DIFFUSE GASTRIC CANCER Is also known as hereditary diffuse cancer of stomach, hereditary diffuse gastric adenocarcinoma, familial diffuse cancer of stomach, familial diffuse gastric cancer, gastric cancer, familial diffuse, fdgc, hdgc, gastric cancer, hereditary diffuse

Description

Hereditary diffuse gastric cancer is a rare epithelial tumor of the stomach, characterized by the development of diffuse (signet ring cell) gastric cancer at a young age, associated with germline heterozygous mutations of CDH1, MAP3K6 and CTNNA1 genes. In early stages it presents with non-specific and vague symptoms, in advanced stages it may cause nausea and vomiting, dysphagia, loss of appetite, abdominal mass or weight loss. Women have an increased risk of lobular breast cancer as well.

Most common symptoms of HEREDITARY DIFFUSE GASTRIC CANCER

  • Neoplasm
  • Cleft palate
  • Carcinoma
  • Cleft lip
  • Cleft upper lip


More info about HEREDITARY DIFFUSE GASTRIC CANCER

SOURCES: OMIM ORPHANET


Potential gene panels for MAP3K6 gene

FoundationOneĀ® Heme Panel

United States.

By Foundation Medicine, Inc. FoundationOneĀ® Heme that also includes the following genes: BCL6 BCL7A ROS1 RUNX1 BLM SDHA SDHB SDHC SDHD SF3B1

More info about this panel

Tempus xO assay Panel

United States.

By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2

More info about this panel


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