LGI1 gene related symptoms and diseases

All the information presented here about the LGI1 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,OMIM,ORPHANET,HGNC, Mendelian Rare Disease Search Engine.

Table of contents:

Main symptoms and clinical features
Other symptoms and clinical features
Related Diseases
Current trends
Suitable testing panels

Top 5 symptoms and clinical features associated to LGI1 gene

Symptoms // Phenotype	% Cases
Seizures	Very Common - Between 80% and 100% cases
Visual hallucinations	Very Common - Between 80% and 100% cases
Focal sensory auditory seizure	Very Common - Between 80% and 100% cases
Deja vu	Very Common - Between 80% and 100% cases
Focal aware seizure	Very Common - Between 80% and 100% cases

Other less frequent symptoms and clinical features

Patients with LGI1 gene alterations may also develop some of the following symptoms and phenotypes:

Commonly - More than 50% cases
Focal sensory seizure
Auditory hallucinations
Generalized tonic-clonic seizures with focal onset
Glioma
Aphasia
Generalized tonic-clonic seizures
Focal impaired awareness seizure
Mutism

And 7 more phenotypes, you can get all of them using our tools for rare diseases.

Rare diseases associated to LGI1 gene

Here you will find a list of rare diseases related to the LGI1. You can also use our tool to get a more accurate diagnosis based on your current symptoms.

AUTOSOMAL DOMINANT EPILEPSY WITH AUDITORY FEATURES

Alternate names

AUTOSOMAL DOMINANT EPILEPSY WITH AUDITORY FEATURES Is also known as partial epilepsy with auditory aura, partial epilepsy with auditory features, adlte, adeaf, autosomal dominant lateral temporal lobe epilepsy, adpeaf, epilepsy, lateral temporal lobe, autosomal dominant, epilepsy, partial, with auditory features

Description

Autosomal dominant lateral temporal lobe epilepsy is a specific form of temporal lobe epilepsy characterized by partial seizures originating from the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature (summary by Winawer et al., 2000). Genetic Heterogeneity of Temporal Lobe EpilepsySee also ETL2 (OMIM ), which maps to chromosome 12q; ETL3 (OMIM ), which maps to chromosome 4q; ETL4 (OMIM ), which maps to chromosome 9q; ETL5 (OMIM ), caused by mutation in the CPA6 gene (OMIM ) on chromosome 8q13; ETL6 (OMIM ), which maps to chromosome 3q25-q26; ETL7 (OMIM ), caused by mutation in the RELN gene (OMIM ) on chromosome 7q22; and ETL8 (OMIM ), caused by mutation in the GAL gene (OMIM ) on chromosome 11q13.

Most common symptoms of AUTOSOMAL DOMINANT EPILEPSY WITH AUDITORY FEATURES

Seizures
Generalized tonic-clonic seizures
Vertigo
Focal-onset seizure
Febrile seizures

More info about AUTOSOMAL DOMINANT EPILEPSY WITH AUDITORY FEATURES

SOURCES: ORPHANET OMIM

Search interest in LGI1

Potential gene panels for LGI1 gene

Epilepsy Advanced Sequencing and CNV Evaluation - Generalized, Absence, Focal,Febrile and Myoclonic Epilepsies Panel

United States.

By Athena Diagnostics Inc Epilepsy Advanced Sequencing and CNV Evaluation - Generalized, Absence, Focal,Febrile and Myoclonic Epilepsies that also includes the following genes: SCN1A SCN1B SCN2A SCN3A SCN5A SCN9A ST3GAL5 SLC2A1 SLC35A2 SLC6A1

LGI1 gene related symptoms and diseases

Top 5 symptoms and clinical features associated to LGI1 gene

Other less frequent symptoms and clinical features

Commonly - More than 50% cases

Rare diseases associated to LGI1 gene

AUTOSOMAL DOMINANT EPILEPSY WITH AUDITORY FEATURES

Alternate names

Description

Most common symptoms of AUTOSOMAL DOMINANT EPILEPSY WITH AUDITORY FEATURES

Search interest in LGI1

Potential gene panels for LGI1 gene

Epilepsy Advanced Sequencing and CNV Evaluation - Generalized, Absence, Focal,Febrile and Myoclonic Epilepsies Panel

Epilepsy Advanced Sequencing and CNV Evaluation Panel

Epilepsy Advanced Sequencing and CNV Evaluation - Syndromic Disorders Panel

NGS Epilepsy/Seizure Panel Panel

Childhood Epilepsy Panel

Epilepsy/Seizure Panel

Comprehensive Epilepsy Panel Panel

Childhood-Onset Epilepsy Panel Panel

CustomNext: Neuro Panel

Neurodevelopment-Expanded Panel

EpiFirst-Focal Panel

EpilepsyNext Panel

EpiRapid reflex EpilepsyNext Panel

MECP2, SCN1B, GABRG2, LGI1, POLG, POLG2, SLC25A22, SPTAN1, SRPX2. NextGeneDx.Complete sequencing by NGS Panel

LGI1. Complete sequencing Panel

CHOP Epilepsy Panel Panel

Epilepsy familial temporal lobe 1 (sequence analysis of LGI1 gene) Panel

Early Infantile Epileptic Encephalopathy Sequencing Panel with CNV Detection Panel

Comprehensive Epilepsy and Seizure Sequencing Panel with CNV Detection Panel

Epilespy, Autosomal Dominant Lateral Temporal, via LGI1 Gene Sequencing with CNV Detection Panel

Epilepsy and Seizure Plus Sequencing Panel with CNV Detection Panel

Familial Focal Epilepsy Panel

Neurogenetic Disorders - panels Panel

Brain Malformations / Neuronal Migration Disorders Panel

Epilepsy Panel

Focal epilepsy panel Panel

AllNeuro panel Panel

Autosomal dominant lateral temporal lobe epilepsy Panel

Idiopathic Generalized and Focal Epilepsy Panel Panel

Single gene testing LGI1 Panel

Epilepsy Panel

Epilepsy, lateral temporal lobe Panel

Epilepsy, lateral temporal lobe Panel

Invitae Epilepsy Panel Panel

Epilepsy, Autosomal dominant lateral temporal lobe: LGI1 gene sequence analysis Panel

EPILEPSY HEREDITARY PANEL Panel

Epilepsy and Seizure Disorders: Sequencing Panel Panel

Neurology: Sequencing Panel Panel

Epilepsy and Seizure Disorders: Deletion/Duplication Panel Panel

Epilepsy NGS Panel Panel

LGI1 Panel

Essential Epilepsy NGS Panel Panel

Idiopathic Generalized Epilepsy NGS Panel Panel

Early-Onset Epileptic Encephalopathy NGS Panel Panel

Comprehensive Epilepsy NGS Panel Panel

Comprehensive Epilepsy Panel Panel

Idiopathic Generalized and Focal Epilepsy Panel Panel

Autosomal dominant lateral temporal lobe epilepsy Panel

EPILEPSY WITH AUDITORY FEATURES (AUTOSOMAL DOMINANT) Panel

EPILEPSY,LATERAL TEMPORAL LOBE (AUTOSOMAL DOMINANT) Panel

PROGRESSIVE MYOCLONIC EPILEPSY/GEFs+ NGS PANEL Panel

Temporal Lobe Lateral Epilepsy, Sequencing LGI1 Gene Panel

Familial Epilepsy and Related Disorders , Panel Massive Sequencing (NGS) 34 Genes Panel

Glioma (Susceptibility to Somatic) , Panel Massive Sequencing (NGS) 12 Genes Panel