LCK gene related symptoms and diseases

All the information presented here about the LCK gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: ORPHANET,NCBIGENE,HGNC,OMIM, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to LCK gene

Symptoms // Phenotype % Cases
Failure to thrive Very Common - Between 80% and 100% cases
Lymphopenia Very Common - Between 80% and 100% cases
Retinal vasculitis Very Common - Between 80% and 100% cases
Panniculitis Very Common - Between 80% and 100% cases
Protracted diarrhea Very Common - Between 80% and 100% cases

Other less frequent symptoms and clinical features

Patients with LCK gene alterations may also develop some of the following symptoms and phenotypes:
  • Commonly - More than 50% cases

  • Decreased proportion of CD4-positive T cells
  • Impaired T cell function
  • Severe combined immunodeficiency
  • Pericarditis
  • Combined immunodeficiency
  • Vasculitis
  • Decreased antibody level in blood
  • Anemia

And 10 more phenotypes, you can get all of them using our tools for rare diseases.

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Rare diseases associated to LCK gene

Here you will find a list of rare diseases related to the LCK. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


SEVERE COMBINED IMMUNODEFICIENCY DUE TO LCK DEFICIENCY


Alternate names

SEVERE COMBINED IMMUNODEFICIENCY DUE TO LCK DEFICIENCY Is also known as scid due to lck deficiency, severe combined immunodeficiency due to lymphocyte-specific protein tyrosine kinase deficiency, scid due to lymphocyte-specific protein tyrosine kinase deficiency

Most common symptoms of SEVERE COMBINED IMMUNODEFICIENCY DUE TO LCK DEFICIENCY

  • Failure to thrive
  • Anemia
  • Fever
  • Diarrhea
  • Immunodeficiency


More info about SEVERE COMBINED IMMUNODEFICIENCY DUE TO LCK DEFICIENCY

SOURCES: OMIM ORPHANET


Potential gene panels for LCK gene

CentoICU platinum plus Panel

Germany.

By Centogene AG - the Rare Disease Company CentoICU platinum plus that also includes the following genes: RMRP BCS1L BDNF RPS19 RPS6KA3 SALL1 SCN1A SCN2A SFTPB SFTPC

More info about this panel

New Born testing (CentoICU) Panel

Germany.

By Centogene AG - the Rare Disease Company New Born testing (CentoICU) that also includes the following genes: RMRP BCS1L BDNF RPS19 RPS6KA3 SALL1 SCN1A SCN2A SFTPB SFTPC

More info about this panel

Immunodeficiency type 22 Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the LCK gene.

More info about this panel

Combined immunodeficiencies Panel Panel

Germany.

By CeGaT GmbH Combined immunodeficiencies Panel that also includes the following genes: RMRP SEMA3E STAT5B STIM1 STK4 TAPBP TBX1 THBD TNFRSF4 CD40

More info about this panel

Invitae Comprehensive Severe Combined Immunodeficiency (SCID) and Combined Immunodeficiency (CID) Panel Panel

United States.

By Invitae Invitae Comprehensive Severe Combined Immunodeficiency (SCID) and Combined Immunodeficiency (CID) Panel that also includes the following genes: STK4 TAPBP TNFRSF4 CD27 CD40LG ZAP70 CARD11 CD3D CD3E CD3G

More info about this panel

Invitae Primary Immunodeficiency Panel Panel

United States.

By Invitae Invitae Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC SEMA3E SH2D1A SH3BP2 SLC7A7 SMARCAL1 BTK STAT1 STAT2

More info about this panel

Invitae Combined Immunodeficiency (CID) Panel Panel

United States.

By Invitae Invitae Combined Immunodeficiency (CID) Panel that also includes the following genes: STK4 TAPBP TNFRSF4 CD27 CD40LG ZAP70 CARD11 CD3G CD8A LRBA

More info about this panel

LCK Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the LCK gene.

More info about this panel

Primary Immunodeficiency Panel Panel

Finland.

By Blueprint Genetics Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC CFB BLM SH2D1A SLC7A7 SMARCAL1 SMARCD2 SRP72 BTK

More info about this panel

Severe Combined Immunodeficiency Panel Panel

Finland.

By Blueprint Genetics Severe Combined Immunodeficiency Panel that also includes the following genes: RMRP BLM SH2D1A SMARCAL1 STAT1 STAT2 STAT3 STAT5B STIM1 STK4

More info about this panel

Caris MI TumorSeek 592-Gene NGS Panel Panel

United States.

By Caris Life Sciences Caris MI TumorSeek 592-Gene NGS Panel that also includes the following genes: BCL6 BCL7A BCL9 BCR ROS1 RPL10 RPL22 RPL5 RPN1 RUNX1

More info about this panel

Providence Personalized Medicine Panel - Solid Tumor Panel

United States.

By Providence Regional Laboratories Providence Health and Services Providence Personalized Medicine Panel - Solid Tumor that also includes the following genes: BCR ROS1 RUNX1 SDHA SDHB SDHC SDHD SF3B1 SRSF2 FOXL2

More info about this panel

Tempus xO assay Panel

United States.

By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2

More info about this panel


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