KRT74 gene related symptoms and diseases
All the information presented here about the KRT74 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: ORPHANET,OMIM,HGNC,NCBIGENE, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to KRT74 gene
| Symptoms // Phenotype | % Cases |
|---|---|
| Hypotrichosis | Common - Between 50% and 80% cases |
| Hyperhidrosis | Common - Between 50% and 80% cases |
| Alopecia | Common - Between 50% and 80% cases |
| Brittle hair | Common - Between 50% and 80% cases |
| Hair-nail ectodermal dysplasia | Uncommon - Between 30% and 50% cases |
Other less frequent symptoms and clinical features
Patients with KRT74 gene alterations may also develop some of the following symptoms and phenotypes:Not very common - Between 30% and 50% cases
- Onycholysis
- Sparse body hair
- Palmoplantar hyperkeratosis
- Ectodermal dysplasia
- Nail dystrophy
- Sparse hair
- Hyperkeratosis
- Hypotrichosis of the scalp
And 31 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to KRT74 gene
Here you will find a list of rare diseases related to the KRT74. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
HYPOTRICHOSIS SIMPLEX OF THE SCALP
Alternate names
HYPOTRICHOSIS SIMPLEX OF THE SCALP Is also known as hypotrichosis, spanish type, htss1, hypotrichosis simplex of the scalp 1, htss, hereditary hypotrichosis simplex of the scalp
Description
Hypotrichosis simplex of the scalp (HSS) is characterized by diffuse progressive hair loss that is confined to the scalp.
Most common symptoms of HYPOTRICHOSIS SIMPLEX OF THE SCALP
- Alopecia
- Hypotrichosis
- Sparse scalp hair
- Hypotrichosis of the scalp
More info about HYPOTRICHOSIS SIMPLEX OF THE SCALP
PURE HAIR AND NAIL ECTODERMAL DYSPLASIA
Alternate names
PURE HAIR AND NAIL ECTODERMAL DYSPLASIA Is also known as hair-nail ectodermal dysplasia, hned, phned, ectodermal dysplasia, 'pure' hair/nail type
Description
Pure hair and nail ectodermal dysplasia is characterised by the association of onychodystrophy and severe hypotrichosis, which is mainly limited to the scalp but may also affect the eyelashes and eyebrows. Less than 20 cases have been reported so far. The mode of transmission is autosomal dominant.
Most common symptoms of PURE HAIR AND NAIL ECTODERMAL DYSPLASIA
- Alopecia
- Hyperhidrosis
- Hyperkeratosis
- Sparse hair
- Papule
More info about PURE HAIR AND NAIL ECTODERMAL DYSPLASIA
WOOLLY HAIR
Alternate names
WOOLLY HAIR Is also known as wooly hair, familial woolly hair syndrome, hereditary woolly hair syndrome, familial wooly hair syndrome, hereditary wooly hair syndrome
Description
Woolly hair is a rare congenital abnormality of the structure of the scalp hair marked by extreme kinkiness of the hair.
Most common symptoms of WOOLLY HAIR
- Strabismus
- Cataract
- Hyperhidrosis
- Hyperkeratosis
- Nevus
More info about WOOLLY HAIR
ECTODERMAL DYSPLASIA 7, HAIR/NAIL TYPE; ECTD7
Description
Some ectodermal dysplasias are here classified as congenital disorders characterized by abnormal development in 2 or more ectodermal structures (hair, nails, teeth, and sweat glands) without other systemic findings. Ectodermal dysplasia of the hair/nail type is a rare congenital condition characterized by hypotrichosis and nail dystrophy without nonectodermal or other ectodermal manifestations.
Most common symptoms of ECTODERMAL DYSPLASIA 7, HAIR/NAIL TYPE; ECTD7
- Alopecia
- Hyperhidrosis
- Nail dystrophy
- Hypotrichosis
- Ectodermal dysplasia
More info about ECTODERMAL DYSPLASIA 7, HAIR/NAIL TYPE; ECTD7
SOURCES: OMIM
HYPOTRICHOSIS 3; HYPT3
Alternate names
HYPOTRICHOSIS 3; HYPT3 Is also known as hypotrichosis simplex of the scalp 2, htss2
Description
Hypotrichosis simplex can affect all body hair (generalized; see {605389}) or be limited to the scalp. Usually patients with the scalp-limited form of hypotrichosis present with normal hair at birth; they experience a progressive, gradual loss of scalp hair beginning at the middle of the first decade and leading to almost complete loss of scalp hair by the third decade. A few sparse, fine, short hairs remain in some individuals. Body hair, beard, eyebrows, axillary hair, teeth, and nails develop normally. Light and electron microscopy of hairs from patients with early hypotrichosis simplex revealed no structural changes, whereas hairs from patients with advanced hypotrichosis showed focal areas of defective cuticular structure. Men and women are equally affected (summary by Betz et al., 2000).For a discussion of genetic heterogeneity of nonsyndromic hypotrichosis, see HYPT1 (OMIM ).
Most common symptoms of HYPOTRICHOSIS 3; HYPT3
- Hyperhidrosis
- Sparse hair
- Hypotrichosis
- Sparse scalp hair
- Hypotrichosis of the scalp
More info about HYPOTRICHOSIS 3; HYPT3
SOURCES: OMIM
Search interest in KRT74
Potential gene panels for KRT74 gene
Hypotrichosis 3 (sequence analysis of KRT74 gene) Panel
Portugal.
By CGC Genetics
This panel specifically test the KRT74 gene.
More info about this panel Portugal.
Ectodermal dysplasia (NGS panel for 8 genes) Panel
Portugal.
By CGC Genetics Ectodermal dysplasia (NGS panel for 8 genes) that also includes the following genes: EDARADD KRT74 EDAR EDA GJB6 HOXC13 KRT85 MSX1
More info about this panel Portugal.
Hypotrichosis (NGS panel of 10 genes) Panel
Portugal.
By CGC Genetics Hypotrichosis (NGS panel of 10 genes) that also includes the following genes: RPL21 SNRPE LPAR6 APCDD1 CDSN LIPH DSG4 KRT71 KRT74 HR
More info about this panel Portugal.
Ectodermal dysplasia (NGS panel for 8 genes) Panel
Portugal.
By CGC Genetics Ectodermal dysplasia (NGS panel for 8 genes) that also includes the following genes: EDARADD KRT74 EDAR EDA GJB6 HOXC13 KRT85 MSX1
More info about this panel Portugal.
Hypotrichosis (NGS panel of 10 genes) Panel
Portugal.
By CGC Genetics Hypotrichosis (NGS panel of 10 genes) that also includes the following genes: RPL21 SNRPE LPAR6 APCDD1 CDSN LIPH DSG4 KRT71 KRT74 HR
More info about this panel Portugal.
Hypotrichosis Comprehensive panel Panel
United States.
By Connective Tissue Gene Tests Hypotrichosis Comprehensive panel that also includes the following genes: RPL21 SNRPE LPAR6 APCDD1 CDSN LIPH DSG4 KRT71 KRT74 HR
More info about this panel United States.
Ectodermal dysplasia Comprehensive panel Panel
United States.
By Connective Tissue Gene Tests Ectodermal dysplasia Comprehensive panel that also includes the following genes: EDARADD KDF1 KRT74 EDAR EDA GJB6 HOXC13 KRT85 MSX1
More info about this panel United States.
Ectodermal dysplasia Deletion / Duplication panel Panel
United States.
By Connective Tissue Gene Tests Ectodermal dysplasia Deletion / Duplication panel that also includes the following genes: EDARADD KDF1 KRT74 EDAR EDA GJB6 HOXC13 KRT85 MSX1
More info about this panel United States.
Hypotrichosis NGS panel Panel
United States.
By Connective Tissue Gene Tests Hypotrichosis NGS panel that also includes the following genes: RPL21 SNRPE LPAR6 APCDD1 CDSN LIPH DSG4 KRT71 KRT74 HR
More info about this panel United States.
Hypotrichosis Deletion / Duplication panel Panel
United States.
By Connective Tissue Gene Tests Hypotrichosis Deletion / Duplication panel that also includes the following genes: RPL21 SNRPE LPAR6 APCDD1 CDSN LIPH DSG4 KRT71 KRT74 HR
More info about this panel United States.
Ectodermal dysplasia NGS panel Panel
United States.
By Connective Tissue Gene Tests Ectodermal dysplasia NGS panel that also includes the following genes: EDARADD KDF1 KRT74 EDAR EDA GJB6 HOXC13 KRT85 MSX1
More info about this panel United States.
Nonsyndromic hypotrichosis panel Panel
Germany.
By Centogene AG - the Rare Disease Company Nonsyndromic hypotrichosis panel that also includes the following genes: RPL21 SNRPE LPAR6 APCDD1 CDSN LIPH DSG4 KRT71 KRT74 HR
More info about this panel Germany.
Autosomal dominant woolly hair with hypotrichosis Panel
Germany.
By Centogene AG - the Rare Disease Company
This panel specifically test the KRT74 gene.
More info about this panel Germany.
Ectodermal dysplasia (including hypotrichosis and hypoplastic hair) Panel Panel
Germany.
By CeGaT GmbH Ectodermal dysplasia (including hypotrichosis and hypoplastic hair) Panel that also includes the following genes: BCS1L SNRPE SOX18 ST14 TRPS1 IFT122 WNT10A EDARADD SHOC2 LPAR6
More info about this panel Germany.
KRT74 Panel
United States.
By Fulgent Genetics Fulgent Genetics
This panel specifically test the KRT74 gene.
More info about this panel United States.
HYPOTRICHOSIS SIMPLEX Panel
Spain.
By Laboratorio de Genetica Clinica SL HYPOTRICHOSIS SIMPLEX that also includes the following genes: RPL21 SNRPE LPAR6 APCDD1 LIPH DSG4 KRT71 KRT74 KRT25
More info about this panel Spain.
Woolly hair Panel
Spain.
By Laboratorio de Genetica Clinica SL Woolly hair that also includes the following genes: LPAR6 LIPH KRT71 KRT74 KRT25
More info about this panel Spain.
Woolly hair/Hypothricosis Simplex: NGS Panel Panel
Spain.
By Laboratorio de Genetica Clinica SL Woolly hair/Hypothricosis Simplex: NGS Panel that also includes the following genes: RPL21 SNRPE LPAR6 APCDD1 CDSN LIPH DSG4 KRT71 KRT74 KRT25
More info about this panel Spain.
Hypotricosis , Panel Massive Sequencing (NGS) 8 Genes Panel
Spain.
By Reference Laboratory Genetics Hypotricosis , Panel Massive Sequencing (NGS) 8 Genes that also includes the following genes: RPL21 LPAR6 APCDD1 CDSN LIPH DSG4 KRT74 HR
More info about this panel Spain.
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