KEL gene related symptoms and diseases

All the information presented here about the KEL gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,HGNC,OMIM, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to KEL gene

Symptoms // Phenotype % Cases
Anemia Very Common - Between 80% and 100% cases
Abnormality of the nervous system Very Common - Between 80% and 100% cases
Hemolytic anemia Very Common - Between 80% and 100% cases
Acanthocytosis Very Common - Between 80% and 100% cases

Rare diseases associated to KEL gene

Here you will find a list of rare diseases related to the KEL. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


BLOOD GROUP--KELL SYSTEM; KEL

Alternate names

BLOOD GROUP--KELL SYSTEM; KEL Is also known as blood group--kell-cellano system

Description

The Kell blood group system is formed by 2 disulfide-linked proteins, Kell and XK. The Kell protein is a type II membrane glycoprotein sharing sequence homology with members of the M13 family of zinc-dependent metalloproteases and possessing enzymatic activity characteristic of that group (summary by Claperon et al., 2007).The Kell blood group system is highly polymorphic, expressing over 25 antigens that have been classified in to 5 antithetical sets of high and low prevalence antigens with the others being independently expressed or having unknown antithetical partners. The different phenotypes are due to single-nucleotide mutations that result in an amino acid substitution (summary by Sha et al., 2006). See, for example, Kell (designated K or K1)/Cellano (k, K2) (T193M; {613883.0001}).Yu et al. (2001) noted that the Kell antigens are the most potent immunogens aside from the A and B antigens of the ABO system (OMIM ) and the D antigen (OMIM ) of the Rh system (see {111700}).

Most common symptoms of BLOOD GROUP--KELL SYSTEM; KEL

  • Anemia
  • Abnormality of the nervous system
  • Hemolytic anemia
  • Acanthocytosis


More info about BLOOD GROUP--KELL SYSTEM; KEL

SOURCES: OMIM


Potential gene panels for KEL gene

Kell K/k Antigen (KEL) Genotyping Panel

United States.

By ARUP Laboratories, Molecular Genetics and Genomics

This panel specifically test the KEL gene.

More info about this panel
United States.

Hemolytic anemia, Kell-system related Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the KEL gene.

More info about this panel
Germany.

Kell (K1/K2) Panel

United States.

By BloodCenter of Wisconsin Diagnostic Laboratories BloodCenter of Wisconsin, part of Versiti

This panel specifically test the KEL gene.

More info about this panel
United States.

Kell (K6/K7) (Jsa/Jsb) Panel

United States.

By BloodCenter of Wisconsin Diagnostic Laboratories BloodCenter of Wisconsin, part of Versiti

This panel specifically test the KEL gene.

More info about this panel
United States.

Red Cell Genotyping Panel Panel

United States.

By BloodCenter of Wisconsin Diagnostic Laboratories BloodCenter of Wisconsin, part of Versiti Red Cell Genotyping Panel that also includes the following genes: RHCE RHD SLC14A1 ACKR1 GYPA GYPB KEL BCAM ART4

More info about this panel
United States.

KEL Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the KEL gene.

More info about this panel
United States.

NeoTYPE® Discovery Profile for Solid Tumors Panel

United States.

By NeoGenomics Laboratories NeoGenomics Laboratories, Inc. NeoTYPE® Discovery Profile for Solid Tumors that also includes the following genes: BCL6 ROS1 RUNX1 BLM SDHA SDHB SDHC SDHD SF3B1 FOXL2

More info about this panel
United States.

Tempus xT assay Panel

United States.

By Tempus Labs, Inc. Tempus xT assay that also includes the following genes: BCL6 RIT1 BCL7A BCR ROS1 RPL5 RPS15 RPS6KB1 RUNX1 RXRA

More info about this panel
United States.

Tempus xO assay Panel

United States.

By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2

More info about this panel
United States.

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