KEL gene related symptoms and diseases
All the information presented here about the KEL gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,HGNC,OMIM, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to KEL gene
Symptoms // Phenotype | % Cases |
---|---|
Anemia | Very Common - Between 80% and 100% cases |
Abnormality of the nervous system | Very Common - Between 80% and 100% cases |
Hemolytic anemia | Very Common - Between 80% and 100% cases |
Acanthocytosis | Very Common - Between 80% and 100% cases |
Rare diseases associated to KEL gene
Here you will find a list of rare diseases related to the KEL. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
BLOOD GROUP--KELL SYSTEM; KEL
Alternate names
BLOOD GROUP--KELL SYSTEM; KEL Is also known as blood group--kell-cellano system
Description
The Kell blood group system is formed by 2 disulfide-linked proteins, Kell and XK. The Kell protein is a type II membrane glycoprotein sharing sequence homology with members of the M13 family of zinc-dependent metalloproteases and possessing enzymatic activity characteristic of that group (summary by Claperon et al., 2007).The Kell blood group system is highly polymorphic, expressing over 25 antigens that have been classified in to 5 antithetical sets of high and low prevalence antigens with the others being independently expressed or having unknown antithetical partners. The different phenotypes are due to single-nucleotide mutations that result in an amino acid substitution (summary by Sha et al., 2006). See, for example, Kell (designated K or K1)/Cellano (k, K2) (T193M; {613883.0001}).Yu et al. (2001) noted that the Kell antigens are the most potent immunogens aside from the A and B antigens of the ABO system (OMIM ) and the D antigen (OMIM ) of the Rh system (see {111700}).
Most common symptoms of BLOOD GROUP--KELL SYSTEM; KEL
- Anemia
- Abnormality of the nervous system
- Hemolytic anemia
- Acanthocytosis
More info about BLOOD GROUP--KELL SYSTEM; KEL
SOURCES: OMIM
Search interest in KEL
Potential gene panels for KEL gene
Kell K/k Antigen (KEL) Genotyping Panel
By ARUP Laboratories, Molecular Genetics and Genomics
This panel specifically test the KEL gene.
More info about this panelHemolytic anemia, Kell-system related Panel
By Centogene AG - the Rare Disease Company
This panel specifically test the KEL gene.
More info about this panelKell (K1/K2) Panel
By BloodCenter of Wisconsin Diagnostic Laboratories BloodCenter of Wisconsin, part of Versiti
This panel specifically test the KEL gene.
More info about this panelKell (K6/K7) (Jsa/Jsb) Panel
By BloodCenter of Wisconsin Diagnostic Laboratories BloodCenter of Wisconsin, part of Versiti
This panel specifically test the KEL gene.
More info about this panelRed Cell Genotyping Panel Panel
By BloodCenter of Wisconsin Diagnostic Laboratories BloodCenter of Wisconsin, part of Versiti Red Cell Genotyping Panel that also includes the following genes: RHCE RHD SLC14A1 ACKR1 GYPA GYPB KEL BCAM ART4
More info about this panelKEL Panel
By Fulgent Genetics Fulgent Genetics
This panel specifically test the KEL gene.
More info about this panelNeoTYPE® Discovery Profile for Solid Tumors Panel
By NeoGenomics Laboratories NeoGenomics Laboratories, Inc. NeoTYPE® Discovery Profile for Solid Tumors that also includes the following genes: BCL6 ROS1 RUNX1 BLM SDHA SDHB SDHC SDHD SF3B1 FOXL2
More info about this panelTempus xT assay Panel
By Tempus Labs, Inc. Tempus xT assay that also includes the following genes: BCL6 RIT1 BCL7A BCR ROS1 RPL5 RPS15 RPS6KB1 RUNX1 RXRA
More info about this panelTempus xO assay Panel
By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2
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