ITGA2 gene related symptoms and diseases

All the information presented here about the ITGA2 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,ORPHANET,HGNC,OMIM, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to ITGA2 gene

Symptoms // Phenotype % Cases
Thrombocytopenia Very Common - Between 80% and 100% cases
Bruising susceptibility Uncommon - Between 30% and 50% cases
Abnormal bleeding Uncommon - Between 30% and 50% cases
Prolonged bleeding time Uncommon - Between 30% and 50% cases
Abnormal thrombocyte morphology Uncommon - Between 30% and 50% cases

Other less frequent symptoms and clinical features

Patients with ITGA2 gene alterations may also develop some of the following symptoms and phenotypes:
  • Not very common - Between 30% and 50% cases

  • Decreased platelet glycoprotein IIb-IIIa
  • Purpura
  • Petechiae
  • Neonatal alloimmune thrombocytopenia
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Rare diseases associated to ITGA2 gene

Here you will find a list of rare diseases related to the ITGA2. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


BLEEDING DIATHESIS DUE TO INTEGRIN ALPHA2-BETA1 DEFICIENCY


Alternate names

BLEEDING DIATHESIS DUE TO INTEGRIN ALPHA2-BETA1 DEFICIENCY Is also known as glycoprotein ia deficiency, gp ia deficiency, collagen platelet receptor deficiency

Most common symptoms of BLEEDING DIATHESIS DUE TO INTEGRIN ALPHA2-BETA1 DEFICIENCY

  • Thrombocytopenia
  • Bruising susceptibility
  • Abnormal bleeding
  • Prolonged bleeding time
  • Abnormal thrombocyte morphology


More info about BLEEDING DIATHESIS DUE TO INTEGRIN ALPHA2-BETA1 DEFICIENCY

SOURCES: ORPHANET OMIM MESH

FETAL AND NEONATAL ALLOIMMUNE THROMBOCYTOPENIA


Alternate names

FETAL AND NEONATAL ALLOIMMUNE THROMBOCYTOPENIA Is also known as nait

Description

Foetal/neonatal alloimmune thrombocytopaenia (NAIT) results from maternal alloimmunisation against foetal platelet antigens inherited from the father and different from those present in the mother, and usually presents as a severe isolated thrombocytopaenia in otherwise healthy newborns.

Most common symptoms of FETAL AND NEONATAL ALLOIMMUNE THROMBOCYTOPENIA

  • Thrombocytopenia
  • Purpura
  • Petechiae
  • Neonatal alloimmune thrombocytopenia


More info about FETAL AND NEONATAL ALLOIMMUNE THROMBOCYTOPENIA

SOURCES: ORPHANET


Potential gene panels for ITGA2 gene

Platelet Disorders Panel

United States.

By Knight Diagnostic Laboratories - Molecular Diagnostic Center Oregon Health & Science University Platelet Disorders that also includes the following genes: RUNX1 STIM1 TBXA2R TBXAS1 USF1 VPS33B VWF WAS GP6 HPS3

More info about this panel

ITGA2 Panel

Germany.

By Institute for Human Genetics University Clinic Freiburg

This panel specifically test the ITGA2 gene.

More info about this panel

Bleeding Disorders Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Bleeding Disorders Sequencing Panel with CNV Detection that also includes the following genes: RUNX1 TBXA2R TBXAS1 VWF WAS ADAMTS13 ABCG5 ABCG8 GP6 HPS3

More info about this panel

Platelet Function Disorder Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Platelet Function Disorder Sequencing Panel with CNV Detection that also includes the following genes: TBXA2R TBXAS1 GP6 HPS3 HPS4 CD36 HPS5 DTNBP1 P2RY12 HPS6

More info about this panel

Glycoprotein Ia C807T polymorphism Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the ITGA2 gene.

More info about this panel

Glycoprotein 1a Deficiency (ITGA2) Panel

Germany.

By MVZ Dortmund Dr. Eberhard & Partner

This panel specifically test the ITGA2 gene.

More info about this panel

Platelet Antigen Genotyping Panel Panel

United States.

By BloodCenter of Wisconsin Diagnostic Laboratories BloodCenter of Wisconsin, part of Versiti Platelet Antigen Genotyping Panel that also includes the following genes: CD109 GP1BA ITGA2 ITGA2B ITGB3

More info about this panel

ITGA2 Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the ITGA2 gene.

More info about this panel

Thrombocytopenia Panel Panel

Finland.

By Blueprint Genetics Thrombocytopenia Panel that also includes the following genes: RUNX1 SRC THBD WAS WIPF1 ADAMTS13 ABCG5 ABCG8 TUBB1 ACTN1

More info about this panel

Comprehensive Hematology Panel Panel

Finland.

By Blueprint Genetics Comprehensive Hematology Panel that also includes the following genes: RHAG RIT1 RPL11 RPL15 RPL35A RPL5 RPS10 RPS19 RPS24 RPS26

More info about this panel


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