INSL3 gene related symptoms and diseases

All the information presented here about the INSL3 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: OMIM,NCBIGENE,HGNC, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to INSL3 gene

Symptoms // Phenotype % Cases
Cryptorchidism Very Common - Between 80% and 100% cases
Hypogonadism Very Common - Between 80% and 100% cases
Abnormality of the kidney Very Common - Between 80% and 100% cases
Infertility Very Common - Between 80% and 100% cases
Renal agenesis Very Common - Between 80% and 100% cases

Other less frequent symptoms and clinical features

Patients with INSL3 gene alterations may also develop some of the following symptoms and phenotypes:
  • Commonly - More than 50% cases

  • Azoospermia
  • Bilateral cryptorchidism
  • Unilateral cryptorchidism
  • Delayed menarche
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Rare diseases associated to INSL3 gene

Here you will find a list of rare diseases related to the INSL3. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


CRYPTORCHIDISM, UNILATERAL OR BILATERAL


Alternate names

CRYPTORCHIDISM, UNILATERAL OR BILATERAL Is also known as undescended testis

Description

Cryptorchidism, or failure of testicular descent, is a common human congenital abnormality with a multifactorial etiology that likely reflects the involvement of endocrine, environmental, and hereditary factors. Cryptorchidism can result in infertility and increases risk for testicular tumors. Testicular descent from abdomen to scrotum occurs in 2 distinct phases: the transabdominal phase and the inguinoscrotal phase (summary by Gorlov et al., 2002).

Most common symptoms of CRYPTORCHIDISM, UNILATERAL OR BILATERAL

  • Cryptorchidism
  • Hypogonadism
  • Abnormality of the kidney
  • Infertility
  • Renal agenesis


More info about CRYPTORCHIDISM, UNILATERAL OR BILATERAL

SOURCES: OMIM


Potential gene panels for INSL3 gene

Male Infertility Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Male Infertility Sequencing Panel with CNV Detection that also includes the following genes: SEMA3A SEMA3E FOXL2 BRDT SOX10 SOX2 SOX3 SOX9 SRA1 SRD5A2

More info about this panel

Disorders of Sex Development (DSD) and Infertility Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Disorders of Sex Development (DSD) and Infertility Sequencing Panel with CNV Detection that also includes the following genes: ROR2 SALL1 BMP15 BMP4 SEMA3A SEMA3E BMP7 FOXL2 BRDT SOS1

More info about this panel

Disorders of Sex Development (DSD) Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Disorders of Sex Development (DSD) Sequencing Panel with CNV Detection that also includes the following genes: ROR2 SALL1 BMP15 BMP4 SEMA3A BMP7 FOXL2 SOS1 SOX10 SOX2

More info about this panel

Male Factor Infertility Panel

Estonia.

By Asper Biogene Asper Biogene LLC Male Factor Infertility that also includes the following genes: TEKT2 XIST USP26 PRDM9 RXFP2 RBMXL2 DDX25 CFTR UTP14C NLRP14

More info about this panel

INSL3 Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the INSL3 gene.

More info about this panel


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