IKZF3 gene related symptoms and diseases

All the information presented here about the IKZF3 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: ORPHANET,OMIM,NCBIGENE,HGNC, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to IKZF3 gene

Symptoms // Phenotype % Cases
Neoplasm Very Common - Between 80% and 100% cases
Rheumatoid arthritis Very Common - Between 80% and 100% cases
Lung adenocarcinoma Very Common - Between 80% and 100% cases
Lymphocytosis Very Common - Between 80% and 100% cases
Cellular immunodeficiency Very Common - Between 80% and 100% cases

Other less frequent symptoms and clinical features

Patients with IKZF3 gene alterations may also develop some of the following symptoms and phenotypes:
  • Commonly - More than 50% cases

  • Chronic lymphatic leukemia
  • Lymphoproliferative disorder
  • B-cell lymphoma
  • Acute leukemia
  • Hodgkin lymphoma
  • Hyperthyroidism
  • Systemic lupus erythematosus
  • Anemia

And 10 more phenotypes, you can get all of them using our tools for rare diseases.

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Rare diseases associated to IKZF3 gene

Here you will find a list of rare diseases related to the IKZF3. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA


Alternate names

B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA Is also known as b-cll, small lymphocytic lymphoma, b-cell chronic lymphoid leukemia, leukemia, chronic lymphatic

Description

B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma (see this term), and the most common form of leukemia in Western countries, affecting elderly adults (mean age of 67 and 72 years) with a slight male predominance (1.7:1), and characterized by a highly variable clinical presentation that can include asymptomatic disease or non-specific B-symptoms such as unintentional weight loss, severe fatigue, fever (without evidence of infection), and night sweats as well as cervical lymphadenopathy, splenomegaly and frequent infections. Some patients can also develop autoimmune complications such as autoimmune hemolytic anemia or immune thrombocytopenia (see these terms). The clinical course is extremely heterogeneous with survival ranging from a few months to several decades.

Most common symptoms of B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA

  • Neoplasm
  • Anemia
  • Splenomegaly
  • Recurrent infections
  • Thrombocytopenia


More info about B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA

SOURCES: OMIM ORPHANET


Potential gene panels for IKZF3 gene

IKZF3 Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the IKZF3 gene.

More info about this panel

Focus::CLL™ NGS Panel Panel

United States.

By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::CLL™ NGS Panel that also includes the following genes: SF3B1 BRAF BTK MED12 TP53 TRAF2 XPO1 ZMYM3 IKZF3 CARD11

More info about this panel

Focus::DLBCL&FL™ NGS Panel Panel

United States.

By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::DLBCL&FL™ NGS Panel that also includes the following genes: BCL6 SGK1 BRAF ARID1A BTK STAT3 STAT6 SYK TNFAIP3 FAS

More info about this panel

Focus::Lymphoma™ NGS Panel Panel

United States.

By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::Lymphoma™ NGS Panel that also includes the following genes: BCL6 SGK1 BRAF ARID1A BTK STAT3 STAT6 SYK TNFAIP3 FAS

More info about this panel

FoundationOne® Heme Panel

United States.

By Foundation Medicine, Inc. FoundationOne® Heme that also includes the following genes: BCL6 BCL7A ROS1 RUNX1 BLM SDHA SDHB SDHC SDHD SF3B1

More info about this panel

Tempus xO assay Panel

United States.

By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2

More info about this panel


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