GCK gene related symptoms and diseases

All the information presented here about the GCK gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: HGNC,OMIM,NCBIGENE,ORPHANET, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to GCK gene

Symptoms // Phenotype % Cases
Diabetes mellitus Common - Between 50% and 80% cases
Type II diabetes mellitus Common - Between 50% and 80% cases
Hyperglycemia Common - Between 50% and 80% cases
Intellectual disability Uncommon - Between 30% and 50% cases
Motor delay Uncommon - Between 30% and 50% cases

Other less frequent symptoms and clinical features

Patients with GCK gene alterations may also develop some of the following symptoms and phenotypes:
  • Not very common - Between 30% and 50% cases

  • Transient neonatal diabetes mellitus
  • Retinopathy
  • Insulin resistance
  • Global developmental delay
  • Failure to thrive
  • Dehydration
  • Intrauterine growth retardation
  • Downturned corners of mouth

And 80 more phenotypes, you can get all of them using our tools for rare diseases.

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Rare diseases associated to GCK gene

Here you will find a list of rare diseases related to the GCK. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


HYPERINSULINISM DUE TO GLUCOKINASE DEFICIENCY


Alternate names

HYPERINSULINISM DUE TO GLUCOKINASE DEFICIENCY Is also known as hyperinsulinemic hypoglycemia due to glucokinase deficiency

Description

Hyperinsulism due to glucokinase deficiency (HIGCK) is a form of diazoxide-sensitive diffuse hyperinsulinism (see this term), caused by a lowered threshold for insulin release, characterized by an excessive/ uncontrolled insulin secretion (inappropriate for the level of glycemia) and recurrent episodes of profound hypoglycemia induced by fasting and protein rich meals, requiring rapid and intensive treatment to prevent neurological sequelae.

Most common symptoms of HYPERINSULINISM DUE TO GLUCOKINASE DEFICIENCY

  • Intellectual disability
  • Seizures
  • Muscle weakness
  • Fatigue
  • Diabetes mellitus


More info about HYPERINSULINISM DUE TO GLUCOKINASE DEFICIENCY

SOURCES: ORPHANET MESH OMIM

MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 2; MODY2


Alternate names

MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 2; MODY2 Is also known as mody, glucokinase-related, mody, type 2

Description

MODY is a form of NIDDM (OMIM ) characterized by monogenic autosomal dominant transmission and early age of onset. For a general phenotypic description and a discussion of genetic heterogeneity of MODY, see {606391}.In a review of the various forms of MODY, Fajans et al. (2001) stated that glucokinase-related MODY2 is a common form of the disorder, especially in children with mild hyperglycemia and in women with gestational diabetes and a family history of diabetes. It has been described in persons of all racial and ethnic groups. More than 130 MODY-associated mutations have been found in the glucokinase gene. Heterozygous mutations in glucokinase are associated with a mild form of nonprogressive hyperglycemia that is usually asymptomatic at diagnosis and is treated with diet alone. The mild fasting hyperglycemia with blood glucose concentrations of 110 to 145 mg/deciliter and impaired glucose tolerance in most affected carriers may be recognized by biochemical testing at a young age, possibly as early as birth. About 50% of the women who are carriers may have gestational diabetes. Less than 50% of the carriers have overt diabetes; many of those who do are obese or elderly. Two percent of MODY2 patients require insulin therapy. Diabetes-associated complications are rare in this form of MODY. MODY was found in 13% of the Caucasian NIDDM families collected in France by Froguel et al. (1991). Gidh-Jain et al. (1993) found that GCK mutations accounted for 56% of MODY families in France.

Most common symptoms of MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 2; MODY2

  • Type II diabetes mellitus
  • Hyperglycemia
  • Glucose intolerance
  • Maternal diabetes
  • Maturity-onset diabetes of the young


More info about MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 2; MODY2

SOURCES: OMIM

MODY


Alternate names

MODY Is also known as maturity-onset diabetes of the young, mason-type diabetes

Description

MODY (maturity-onset diabetes of the young) is a rare, familial, clinically and genetically heterogeneous form of diabetes characterized by young age of onset (generally 10-45 years of age) with maintenance of endogenous insulin production, lack of pancreatic beta-cell autoimmunity, absence of obesity and insulin resistance and extra-pancreatic manifestations in some subtypes.

Most common symptoms of MODY

  • Hypertension
  • Diabetes mellitus
  • Retinopathy
  • Type II diabetes mellitus
  • Insulin resistance


More info about MODY

SOURCES: OMIM ORPHANET

PERMANENT NEONATAL DIABETES MELLITUS


Alternate names

PERMANENT NEONATAL DIABETES MELLITUS Is also known as monogenic diabetes of infancy, pndm

Description

Permanent neonatal diabetes mellitus (PNDM) is a monogenic form of neonatal diabetes (NDM, see this term) characterized by persistent hyperglycemia within the first 12 months of life in general, requiring continuous insulin treatment.

Most common symptoms of PERMANENT NEONATAL DIABETES MELLITUS

  • Intellectual disability
  • Global developmental delay
  • Hearing impairment
  • Ataxia
  • Failure to thrive


More info about PERMANENT NEONATAL DIABETES MELLITUS

SOURCES: ORPHANET

DIABETES MELLITUS, PERMANENT NEONATAL; PNDM


Alternate names

DIABETES MELLITUS, PERMANENT NEONATAL; PNDM Is also known as diabetes mellitus, permanent, of infancy, pdmi

Description

Neonatal diabetes mellitus (NDM), defined as insulin-requiring hyperglycemia within the first 3 months of life, is a rare entity, with an estimated incidence of 1 in 400,000 neonates (Shield, 2000). In about half of the neonates, diabetes is transient (see {601410}) and resolves at a median age of 3 months, whereas the rest have a permanent insulin-dependent form of diabetes (PNDM). In a significant number of patients with transient neonatal diabetes mellitus, type II diabetes (see {125853}) appears later in life (Arthur et al., 1997). PNDM is distinct from childhood-onset autoimmune diabetes mellitus type I (IDDM ).Massa et al. (2005) noted that the diagnostic time limit for PNDM has changed over the years, ranging from onset within 30 days of birth to 3 months of age. However, as patients with the clinical phenotype caused by mutation in the KCNJ11 gene have been identified with onset up to 6 months of age, Massa et al. (2005) suggested that the term 'permanent diabetes mellitus of infancy' (PDMI) replace PNDM as a more accurate description, and include those who present up to 6 months of age. The authors suggested that the new acronym be linked to the gene product (e.g., GCK-PDMI, KCNJ11-PDMI) to avoid confusion with patients with early-onset, autoimmune type I diabetes.Colombo et al. (2008) proposed that, because individuals with INS gene mutations may present with diabetes well beyond 6 months of age and cannot be distinguished from patients with type 1 diabetes except for the absence of type 1 diabetes autoantibodies, the term PNDM should be replaced with 'monogenic diabetes of infancy (MDI),' a broad definition including any form of diabetes, permanent or transient, with onset during the first years of life and caused by a single gene defect.

Most common symptoms of DIABETES MELLITUS, PERMANENT NEONATAL; PNDM

  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Failure to thrive
  • Muscle weakness


More info about DIABETES MELLITUS, PERMANENT NEONATAL; PNDM

SOURCES: OMIM ORPHANET

DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM


Alternate names

DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM Is also known as noninsulin-dependent diabetes mellitus, maturity-onset diabetes, diabetes mellitus, type ii, t2d

Most common symptoms of DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM

  • Diabetes mellitus
  • Type II diabetes mellitus
  • Insulin resistance
  • Type I diabetes mellitus
  • Hyperinsulinemia


More info about DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM

SOURCES: OMIM ORPHANET


Potential gene panels for GCK gene

MitoMet®Plus aCGH Analysis Panel

United States.

By Baylor Miraca Genetics Laboratories MitoMet®Plus aCGH Analysis that also includes the following genes: RGS9 RHO GRK1 RLBP1 RNASEL BCS1L RP1 RP2 RP9 RPE65

More info about this panel

Congenital Hyperinsulinism Evaluation Panel

United States.

By Athena Diagnostics Inc Congenital Hyperinsulinism Evaluation that also includes the following genes: GCK GLUD1 ABCC8 KCNJ11

More info about this panel

Neonatal Diabetes Mellitus Evaluation Panel

United States.

By Athena Diagnostics Inc Neonatal Diabetes Mellitus Evaluation that also includes the following genes: GCK ABCC8 INS PDX1 KCNJ11

More info about this panel

Monogenic Diabetes (MODY) Five Gene Evaluation (GCK,HNF1A,HNF1B,HNF4A,IPF1) Panel

United States.

By Athena Diagnostics Inc Monogenic Diabetes (MODY) Five Gene Evaluation (GCK,HNF1A,HNF1B,HNF4A,IPF1) that also includes the following genes: HNF1A HNF1B GCK HNF4A PDX1

More info about this panel

GCK (NDM) DNA Sequencing Test Panel

United States.

By Athena Diagnostics Inc

This panel specifically test the GCK gene.

More info about this panel

GCK (CH) DNA Sequencing Test Panel

United States.

By Athena Diagnostics Inc

This panel specifically test the GCK gene.

More info about this panel

GCK (MODY2) DNA Sequencing and Deletion Test Panel

United States.

By Athena Diagnostics Inc

This panel specifically test the GCK gene.

More info about this panel

Monogenic Diabetes (MODY) Four Gene Evaluation (GCK,HNF1A, HNF1B, HNF4A) Panel

United States.

By Athena Diagnostics Inc Monogenic Diabetes (MODY) Four Gene Evaluation (GCK,HNF1A, HNF1B, HNF4A) that also includes the following genes: HNF1A HNF1B GCK HNF4A

More info about this panel

Monogenic Diabetes (MODY) Three Gene Evaluation (GCK,HNF1A, HNF1B) Panel

United States.

By Athena Diagnostics Inc Monogenic Diabetes (MODY) Three Gene Evaluation (GCK,HNF1A, HNF1B) that also includes the following genes: HNF1A HNF1B GCK

More info about this panel

Monogenic Diabetes (MODY) Two Gene Evaluation (GCK,HNF1A) Panel

United States.

By Athena Diagnostics Inc Monogenic Diabetes (MODY) Two Gene Evaluation (GCK,HNF1A) that also includes the following genes: HNF1A GCK

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Maturity-Onset Diabetes of the Young Panel

United States.

By Knight Diagnostic Laboratories - Molecular Diagnostic Center Oregon Health & Science University Maturity-Onset Diabetes of the Young that also includes the following genes: BLK SLC2A2 HNF1A HNF1B KLF11 WFS1 NEUROG3 IER3IP1 RFX6 CP

More info about this panel

Level 1: Congenital Hyperinsulinisim Panel Panel

United States.

By Genetic Diagnostic Laboratory University of Pennsylvania School of Medicine Level 1: Congenital Hyperinsulinisim Panel that also includes the following genes: GCK GLUD1 ABCC8 KCNJ11

More info about this panel

Level 2: Expanded Congenital Hyperinsulinism Panel Panel

United States.

By Genetic Diagnostic Laboratory University of Pennsylvania School of Medicine Level 2: Expanded Congenital Hyperinsulinism Panel that also includes the following genes: SLC16A1 GCK GLUD1 HADH ABCC8 KCNJ11

More info about this panel

Maturity-onset Diabetes of the Young Panel Panel

United States.

By Genetic Diagnostic Laboratory University of Pennsylvania School of Medicine Maturity-onset Diabetes of the Young Panel that also includes the following genes: BLK HNF1A HNF1B KLF11 CEL AKT2 GCK HNF4A ABCC8 INS

More info about this panel

MODY Deletion/Duplication Panel Panel

United States.

By Genetic Services Laboratory University of Chicago MODY Deletion/Duplication Panel that also includes the following genes: BLK HNF1A HNF1B KLF11 CEL APPL1 GCK HNF4A ABCC8 INS

More info about this panel

Neonatal Diabetes Mellitus and Maturity-Onset Diabetes of the Young Deletion/Duplication Panel Panel

United States.

By Genetic Services Laboratory University of Chicago Neonatal Diabetes Mellitus and Maturity-Onset Diabetes of the Young Deletion/Duplication Panel that also includes the following genes: BLK SLC2A2 STAT3 KLF11 WFS1 ZBTB20 NEUROG3 LRBA CDKN1C CEL

More info about this panel

Neonatal Diabetes Mellitus and Maturity-Onset Diabetes of the Young Panel Panel

United States.

By Genetic Services Laboratory University of Chicago Neonatal Diabetes Mellitus and Maturity-Onset Diabetes of the Young Panel that also includes the following genes: BLK SLC2A2 STAT3 KLF11 WFS1 ZBTB20 NEUROG3 LRBA CDKN1C CEL

More info about this panel

Tier 1 Panel: Diazoxide Unresponsive Hyperinsulinism Panel

United States.

By Genetic Services Laboratory University of Chicago Tier 1 Panel: Diazoxide Unresponsive Hyperinsulinism that also includes the following genes: GCK ABCC8 KCNJ11

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Comprehensive Neonatal Diabetes Mutation Analysis Panel

United States.

By Genetic Services Laboratory University of Chicago Comprehensive Neonatal Diabetes Mutation Analysis that also includes the following genes: ZFP57 EIF2AK3 GATA4 GATA6 GCK MNX1 HYMAI ABCC8 INS FOXP3

More info about this panel

GCK deletion/duplication analysis Panel

United States.

By Genetic Services Laboratory University of Chicago

This panel specifically test the GCK gene.

More info about this panel

GCK sequencing Panel

United States.

By Genetic Services Laboratory University of Chicago

This panel specifically test the GCK gene.

More info about this panel

Comprehensive Familial Hyperinsulinism Panel Panel

United States.

By Genetic Services Laboratory University of Chicago Comprehensive Familial Hyperinsulinism Panel that also includes the following genes: SLC16A1 HNF1A UCP2 KDM6A GCK GLUD1 HADH HNF4A ABCC8 INSR

More info about this panel

MODY Panel Panel

United States.

By Genetic Services Laboratory University of Chicago MODY Panel that also includes the following genes: BLK HNF1A HNF1B KLF11 CEL APPL1 GCK HNF4A ABCC8 INS

More info about this panel

Neonatal Diabetes Mellitus Deletion/Duplication Analysis Panel

United States.

By Genetic Services Laboratory University of Chicago Neonatal Diabetes Mellitus Deletion/Duplication Analysis that also includes the following genes: ZFP57 EIF2AK3 GCK ABCC8 INS FOXP3 PDX1 KCNJ11

More info about this panel

Neonatal Diabetes Mellitus Sequencing Panel Panel

United States.

By Genetic Services Laboratory University of Chicago Neonatal Diabetes Mellitus Sequencing Panel that also includes the following genes: ZFP57 EIF2AK3 GATA4 GATA6 GCK MNX1 ABCC8 INS FOXP3 PDX1

More info about this panel

GCK-Related Hyperinsulinism Panel

New Zealand.

By Molecular Genetics Laboratory - Diagnostics Genetics LabPLUS - Auckland City Hospital

This panel specifically test the GCK gene.

More info about this panel

Maturity onset diabetes of the young (MODY) Panel Panel

New Zealand.

By Molecular Genetics Laboratory - Diagnostics Genetics LabPLUS - Auckland City Hospital Maturity onset diabetes of the young (MODY) Panel that also includes the following genes: HNF1A HNF1B GCK HNF4A

More info about this panel

MODY Panel Panel

United States.

By Ambry Genetics MODY Panel that also includes the following genes: HNF1A HNF1B GCK HNF4A PDX1

More info about this panel

GCK mutation analysis Panel

Netherlands.

By Laboratory of genome diagnostics Academic Medical Center, University of Amsterdam

This panel specifically test the GCK gene.

More info about this panel

GCK. Complete sequencing Panel

Spain.

By Instituto de Medicina Genomica Instituto de Medicina Genomica

This panel specifically test the GCK gene.

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HNF4,GCK,HNF1A,HNF1B, NextGeneDx.Complete sequencing by NGS Panel

Spain.

By Instituto de Medicina Genomica Instituto de Medicina Genomica HNF4,GCK,HNF1A,HNF1B, NextGeneDx.Complete sequencing by NGS that also includes the following genes: HNF1A HNF1B GCK HNF4A

More info about this panel

MODY 2 (sequence analysis of GCK gene) Panel

Portugal.

By CGC Genetics

This panel specifically test the GCK gene.

More info about this panel

GCK-Related Hyperinsulinism Panel

Portugal.

By CGC Genetics

This panel specifically test the GCK gene.

More info about this panel

GCK-Related Permanent Neonatal Diabetes Mellitus Panel

Portugal.

By CGC Genetics

This panel specifically test the GCK gene.

More info about this panel

MODY (deletion/duplication analysis of GCK, HNF1A, HNF1B and HNF4A genes) Panel

Portugal.

By CGC Genetics MODY (deletion/duplication analysis of GCK, HNF1A, HNF1B and HNF4A genes) that also includes the following genes: HNF1A HNF1B GCK HNF4A

More info about this panel

Permanent neonatal diabetes mellitus (deletion/duplication analysis of GCK gene) Panel

Portugal.

By CGC Genetics

This panel specifically test the GCK gene.

More info about this panel

MODY (NGS panel for 13 genes) Panel

Portugal.

By CGC Genetics MODY (NGS panel for 13 genes) that also includes the following genes: BLK HNF1A HNF1B KLF11 CEL GCK HNF4A ABCC8 INS PDX1

More info about this panel

Diabetes mellitus permanent neonatal (NGS panel for 13 genes) Panel

Portugal.

By CGC Genetics Diabetes mellitus permanent neonatal (NGS panel for 13 genes) that also includes the following genes: SLC19A2 HNF1B IER3IP1 RFX6 PTF1A GLIS3 GATA6 GCK ABCC8 INS

More info about this panel

Familial hyperinsulinism (NGS panel of 9 genes) Panel

Portugal.

By CGC Genetics Familial hyperinsulinism (NGS panel of 9 genes) that also includes the following genes: SLC16A1 UCP2 GCK GLUD1 HADH HNF4A ABCC8 INSR KCNJ11

More info about this panel

Familial hyperinsulinism (NGS panel of 9 genes) Panel

Portugal.

By CGC Genetics Familial hyperinsulinism (NGS panel of 9 genes) that also includes the following genes: SLC16A1 UCP2 GCK GLUD1 HADH HNF4A ABCC8 INSR KCNJ11

More info about this panel

Permanent neonatal diabetes mellitus Panel

Germany.

By Laboratory for Molecular Diagnostics Center for Nephrology and Metabolic Disorders Permanent neonatal diabetes mellitus that also includes the following genes: GCK ABCC8 INS KCNJ11

More info about this panel

Maturity-onset diabetes of the young, type 2 Panel

Germany.

By Laboratory for Molecular Diagnostics Center for Nephrology and Metabolic Disorders

This panel specifically test the GCK gene.

More info about this panel

Hyperinsulinemic hypoglycemia familial 3 Panel

Germany.

By Laboratory for Molecular Diagnostics Center for Nephrology and Metabolic Disorders

This panel specifically test the GCK gene.

More info about this panel

Permanent neonatal diabetes mellitus Panel

Germany.

By Laboratory for Molecular Diagnostics Center for Nephrology and Metabolic Disorders Permanent neonatal diabetes mellitus that also includes the following genes: GCK ABCC8 INS KCNJ11

More info about this panel

Maturity Onset Diabetes of the Young (Types 1 to 10) Panel

Germany.

By Laboratory for Molecular Diagnostics Center for Nephrology and Metabolic Disorders Maturity Onset Diabetes of the Young (Types 1 to 10) that also includes the following genes: BLK HNF1A HNF1B KLF11 CEL GCK HNF4A INS PDX1 NEUROD1

More info about this panel

Neonatal Diabetes Mellitus Panel

Germany.

By Laboratory for Molecular Diagnostics Center for Nephrology and Metabolic Disorders Neonatal Diabetes Mellitus that also includes the following genes: ZFP57 GCK ABCC8 INS PDX1 KCNJ11

More info about this panel

GCK-Related Hyperinsulinism Panel

United Kingdom.

By Exeter Molecular Genetics Laboratory

This panel specifically test the GCK gene.

More info about this panel

Maturity-Onset Diabetes of the Young Subtype GCK Panel

United Kingdom.

By Exeter Molecular Genetics Laboratory

This panel specifically test the GCK gene.

More info about this panel

Congenital Hyperinsulinism Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Congenital Hyperinsulinism Sequencing Panel with CNV Detection that also includes the following genes: SLC16A1 HNF1A UCP2 GCK GLUD1 HADH HNF4A ABCC8 KCNJ11

More info about this panel

Hyperglycemia and Hypoglycemia via GCK Gene Sequencing with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics

This panel specifically test the GCK gene.

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Maturity Onset Diabetes of the Young (MODY) Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Maturity Onset Diabetes of the Young (MODY) Sequencing Panel with CNV Detection that also includes the following genes: BLK HNF1A HNF1B KLF11 APPL1 GCK HNF4A ABCC8 INS PDX1

More info about this panel

GCK Panel

Slovakia.

By Department of Clinical Genetics St. Elisabeth Cancer Institute

This panel specifically test the GCK gene.

More info about this panel

Maturity-onset diabetes of the young type 2 Panel

Germany.

By Institute of Human Genetics Uniklinik RWTH Aachen

This panel specifically test the GCK gene.

More info about this panel

Nephrology Endocrinology and Electrolytes - panels Panel

Germany.

By MGZ Medical Genetics Center Nephrology Endocrinology and Electrolytes - panels that also includes the following genes: ROBO2 SALL1 BLK BMP4 BMP7 SIX1 SIX2 SIX5 SLC12A1 SLC12A3

More info about this panel

ABCC8-Related Hyperinsulinism Panel

Germany.

By Bioscientia GmbH Center for Human Genetics

This panel specifically test the GCK gene.

More info about this panel

Maturity-Onset Diabetes of the Young Type 2 Panel

Germany.

By Bioscientia GmbH Center for Human Genetics

This panel specifically test the GCK gene.

More info about this panel

Neonatal Diabetes Panel

Germany.

By Synlab MVZ Humane Genetik München Synlab MVZ Humane Genetik München Neonatal Diabetes that also includes the following genes: GCK ABCC8 KCNJ11

More info about this panel

Maturity Onset Diabetes of the Young Panel

Germany.

By Synlab MVZ Humane Genetik München Synlab MVZ Humane Genetik München Maturity Onset Diabetes of the Young that also includes the following genes: HNF1A HNF1B KLF11 GCK HNF4A PDX1 NEUROD1

More info about this panel

Hyperinsulinism Panel

Germany.

By Synlab MVZ Humane Genetik München Synlab MVZ Humane Genetik München Hyperinsulinism that also includes the following genes: GCK GLUD1 ABCC8 KCNJ11

More info about this panel

MODY panel Panel

Germany.

By Centogene AG - the Rare Disease Company MODY panel that also includes the following genes: BLK HNF1A HNF1B KLF11 CEL ZFP57 RFX6 GCK HNF4A ABCC8

More info about this panel

Maturity-onset diabetes of the young type 2 Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the GCK gene.

More info about this panel

Hyperinsulinemic hypoglycemia type 3 Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the GCK gene.

More info about this panel

CentoICU platinum plus Panel

Germany.

By Centogene AG - the Rare Disease Company CentoICU platinum plus that also includes the following genes: RMRP BCS1L BDNF RPS19 RPS6KA3 SALL1 SCN1A SCN2A SFTPB SFTPC

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New Born testing (CentoICU) Panel

Germany.

By Centogene AG - the Rare Disease Company New Born testing (CentoICU) that also includes the following genes: RMRP BCS1L BDNF RPS19 RPS6KA3 SALL1 SCN1A SCN2A SFTPB SFTPC

More info about this panel

Maturity-Onset Diabetes of the Young Type 2 Panel

Italy.

By Medical Genetics Laboratory Bambino Gesù Children's Hospital

This panel specifically test the GCK gene.

More info about this panel

ABCC8-Related Hyperinsulinism Panel

Germany.

By bio.logis Center for Human Genetics Diagnosticum ABCC8-Related Hyperinsulinism that also includes the following genes: GCK GLUD1 HADH HNF4A ABCC8 PDX1 KCNJ11

More info about this panel

Maturity onset diabetes mellitus in young Panel

Germany.

By bio.logis Center for Human Genetics Diagnosticum Maturity onset diabetes mellitus in young that also includes the following genes: BLK HNF1A HNF1B KLF11 CEL GCK HNF4A INS PDX1 NEUROD1

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Nuclear encoded Mitochondriopathies Panel Panel

Germany.

By CeGaT GmbH Nuclear encoded Mitochondriopathies Panel that also includes the following genes: RMRP BCS1L MRPL3 SACS SCO1 SCO2 SDHA SDHB SDHC SDHD

More info about this panel

Single gene testing GCK Panel

Germany.

By CeGaT GmbH

This panel specifically test the GCK gene.

More info about this panel

GCK Panel

Spain.

By Innovagenomics Innovagenomics S.L

This panel specifically test the GCK gene.

More info about this panel

Maturity-Onset Diabetes of the Young Type 2 (GCK, MODY2) Panel

Germany.

By MVZ Dortmund Dr. Eberhard & Partner

This panel specifically test the GCK gene.

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Maturity Onset Diabetes of the Young (MODY) Panel

Estonia.

By Asper Biogene Asper Biogene LLC Maturity Onset Diabetes of the Young (MODY) that also includes the following genes: BLK HNF1A HNF1B KLF11 CEL ZFP57 RFX6 GCK HNF4A ABCC8

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Cardiovascular Diseases_General Panel Panel

Spain.

By Health in Code Cardiovascular Diseases_General Panel that also includes the following genes: RIT1 MRPL3 RRAS RYR1 RYR2 SAR1B BLK SCN10A SCN1B SCN2B

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Maturity-onsetdiabetes of the youngMODY Panel

Spain.

By Health in Code Maturity-onsetdiabetes of the youngMODY that also includes the following genes: BLK SLC2A2 HNF1A HNF1B KLF11 WFS1 NEUROG3 CEL IER3IP1 TBC1D4

More info about this panel

Dyslipidemias / Early atherosclerosis Panel

Spain.

By Health in Code Dyslipidemias / Early atherosclerosis that also includes the following genes: RYR1 SAR1B BLK SLCO1B1 SLC22A8 SLC2A2 HNF1A HNF1B KLF11 WFS1

More info about this panel

Diabetes mellitus, gestational Panel

Austria.

By Praxis fuer Humangenetik Wien

This panel specifically test the GCK gene.

More info about this panel

Diabetes mellitus, noninsulin-dependent, late onset Panel

Austria.

By Praxis fuer Humangenetik Wien

This panel specifically test the GCK gene.

More info about this panel

Hyperinsulinemic hypoglycemia, familial, 3 Panel

Austria.

By Praxis fuer Humangenetik Wien

This panel specifically test the GCK gene.

More info about this panel

MODY 02 Panel

Austria.

By Praxis fuer Humangenetik Wien

This panel specifically test the GCK gene.

More info about this panel

GCK Gene Sequencing Panel

Colombia.

By GENETIX Centro de Investigación en Genética Humana y Reproductiva

This panel specifically test the GCK gene.

More info about this panel

MODY 1/2/3 (Maturity onset diabetes of the young) Panel

Singapore.

By Molecular Diagnosis Centre National University Hospital MODY 1/2/3 (Maturity onset diabetes of the young) that also includes the following genes: HNF1A GCK HNF4A

More info about this panel

Diabetes mellitus, gestational Panel

Slovakia.

By MedGene

This panel specifically test the GCK gene.

More info about this panel

Diabetes mellitus, noninsulin-dependent, late onset Panel

Slovakia.

By MedGene

This panel specifically test the GCK gene.

More info about this panel

Hyperinsulinemic hypoglycemia, familial, 3 Panel

Slovakia.

By MedGene

This panel specifically test the GCK gene.

More info about this panel

MODY 02 Panel

Slovakia.

By MedGene

This panel specifically test the GCK gene.

More info about this panel

MODY type 2: GCK gene sequence analysis Panel

Spain.

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases

This panel specifically test the GCK gene.

More info about this panel

DIABETES (MODY) Panel

Spain.

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases DIABETES (MODY) that also includes the following genes: BLK SLC2A2 HNF1A HNF1B KLF11 GCK HNF4A PDX1 KCNJ11 NEUROD1

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Diabetes mellitus, neonatal permanent Panel

Spain.

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases Diabetes mellitus, neonatal permanent that also includes the following genes: SLC19A2 HNF1B WFS1 NEUROG3 RFX6 PTF1A GLIS3 EIF2AK3 GATA6 GCK

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FAMILIAR HYPERINSULINISM AND HYPERAMMONEMIA Panel

Spain.

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases FAMILIAR HYPERINSULINISM AND HYPERAMMONEMIA that also includes the following genes: SLC16A1 SLC25A15 HNF1A UCP2 GCK GLUD1 HADH HNF4A ABCC8 INSR

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Endocrine Disorders: Sequencing Panel Panel

United States.

By EGL Genetic Diagnostics Eurofins Clinical Diagnostics Endocrine Disorders: Sequencing Panel that also includes the following genes: BLK BMP15 SLC2A2 TAC3 TACR3 HNF1A HNF1B KLF11 WFS1 ZMPSTE24

More info about this panel

Maturity Onset Diabetes of the Young (MODY): Sequencing Panel Panel

United States.

By EGL Genetic Diagnostics Eurofins Clinical Diagnostics Maturity Onset Diabetes of the Young (MODY): Sequencing Panel that also includes the following genes: HNF1A GCK HNF4A PDX1

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Endocrine Disorders: Deletion/Duplication Panel Panel

United States.

By EGL Genetic Diagnostics Eurofins Clinical Diagnostics Endocrine Disorders: Deletion/Duplication Panel that also includes the following genes: BLK BMP15 SLC2A2 TAC3 TACR3 HNF1A HNF1B KLF11 WFS1 ZMPSTE24

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Diabetes-Obesity NGS Panel Panel

United States.

By Fulgent Genetics Fulgent Genetics Diabetes-Obesity NGS Panel that also includes the following genes: BDNF SDCCAG8 SIM1 HNF1A HNF1B WFS1 ARL6 NEUROG3 TRIM32 CEL

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Hyperinsulinism NGS Panel Panel

United States.

By Fulgent Genetics Fulgent Genetics Hyperinsulinism NGS Panel that also includes the following genes: SLC16A1 UCP2 GCK GLUD1 HADH HNF4A ABCC8 INS INSR PDX1

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Intellectual Disability NGS Panel Panel

United States.

By Fulgent Genetics Fulgent Genetics Intellectual Disability NGS Panel that also includes the following genes: BCS1L RPS6KA3 SACS BIN1 SCN1A SCN8A SDCCAG8 SGCA SGSH ST3GAL3

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MODY Neonatal Diabetes NGS Panel Panel

United States.

By Fulgent Genetics Fulgent Genetics MODY Neonatal Diabetes NGS Panel that also includes the following genes: BLK SLC2A2 HNF1A HNF1B KLF11 WFS1 NEUROG3 CEL IER3IP1 ZFP57

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Nuclear-Mito NGS Panel Panel

United States.

By Fulgent Genetics Fulgent Genetics Nuclear-Mito NGS Panel that also includes the following genes: RNASEL BCS1L RPL35A MRPL3 RYR1 RYR2 SACS ACSM3 SARDH ATXN7

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GCK Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the GCK gene.

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MODY Panel Panel

Finland.

By Blueprint Genetics MODY Panel that also includes the following genes: BLK HNF1A HNF1B KLF11 RFX6 GCK HNF4A ABCC8 INS PDX1

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Comprehensive Monogenic Diabetes Panel Panel

Finland.

By Blueprint Genetics Comprehensive Monogenic Diabetes Panel that also includes the following genes: BLK SLC16A1 SLC2A2 HNF1A HNF1B KLF11 UCP2 WFS1 NEUROG3 ZFP57

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Comprehensive Metabolism Panel Panel

Finland.

By Blueprint Genetics Comprehensive Metabolism Panel that also includes the following genes: BCS1L CNNM2 RYR1 CNNM4 SCN4A SEC23B SGSH SI SLC40A1 SLC12A3

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Hypoglycemia, Hyperinsulinism and Ketone Metabolism Panel Panel

Finland.

By Blueprint Genetics Hypoglycemia, Hyperinsulinism and Ketone Metabolism Panel that also includes the following genes: SLC16A1 SLC2A2 HNF1A UCP2 RBCK1 NHLRC1 PTF1A ACSF3 AGL ENO3

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MODY syndrome type 2 Panel

Spain.

By Bioarray

This panel specifically test the GCK gene.

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Familial Hyperinsulinism NGS and Deletion/Duplication Panel Panel

United States.

By DDC Clinic Molecular Diagnostics Laboratory DDC Clinic, Center for Special Needs Children Familial Hyperinsulinism NGS and Deletion/Duplication Panel that also includes the following genes: SLC16A1 HNF1A UCP2 GCK GLUD1 HADH HNF4A ABCC8 INSR KCNJ11

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GCK Gene Sequencing and Deletion/Duplication Analysis Panel

United States.

By DDC Clinic Molecular Diagnostics Laboratory DDC Clinic, Center for Special Needs Children

This panel specifically test the GCK gene.

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Maturity-Onset Diabetes of the Young NGS and Deletion/Duplication Panel Panel

United States.

By DDC Clinic Molecular Diagnostics Laboratory DDC Clinic, Center for Special Needs Children Maturity-Onset Diabetes of the Young NGS and Deletion/Duplication Panel that also includes the following genes: BLK HNF1A HNF1B KLF11 CEL GCK HNF4A ABCC8 INS PDX1

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GCK Gene Sequencing and Deletion/Duplication Analysis Panel

United States.

By DDC Clinic Molecular Diagnostics Laboratory DDC Clinic, Center for Special Needs Children

This panel specifically test the GCK gene.

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Monogenic Diabetes NGS and Deletion/Duplication Panel Panel

United States.

By DDC Clinic Molecular Diagnostics Laboratory DDC Clinic, Center for Special Needs Children Monogenic Diabetes NGS and Deletion/Duplication Panel that also includes the following genes: BLK SLC16A1 SLC2A2 HNF1A HNF1B KLF11 UCP2 WFS1 NEUROG3 CEL

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FAMILIAL HYPERINSULINEMIC HYPOGLYCEMIA (FAMILIAL HYPERINSULINISM) Panel

Spain.

By Laboratorio de Genetica Clinica SL FAMILIAL HYPERINSULINEMIC HYPOGLYCEMIA (FAMILIAL HYPERINSULINISM) that also includes the following genes: GCK GLUD1 INSR KCNJ11

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MATURITY-ONSET DIABETES OF THE YOUNG (MODY) TYPE 2 Panel

Spain.

By Laboratorio de Genetica Clinica SL

This panel specifically test the GCK gene.

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DIABETES MODY & NEONATAL DIABETES : NGS PANEL Panel

Spain.

By Laboratorio de Genetica Clinica SL DIABETES MODY & NEONATAL DIABETES : NGS PANEL that also includes the following genes: BLK SLC2A2 HNF1A HNF1B KLF11 NEUROG3 IER3IP1 ZFP57 RFX6 PTF1A

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FAMILIAL HYPERINSULINEMIC HYPOGLYCEMIA (FAMILIAL HYPERINSULINISM) NGS PANEL Panel

Spain.

By Laboratorio de Genetica Clinica SL FAMILIAL HYPERINSULINEMIC HYPOGLYCEMIA (FAMILIAL HYPERINSULINISM) NGS PANEL that also includes the following genes: SLC16A1 GCK GLUD1 HADH ABCC8 INSR KCNJ11

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MODY panel Panel

Canada.

By LifeLabs Genetics MODY panel that also includes the following genes: BLK HNF1A HNF1B KLF11 CEL ZFP57 RFX6 GCK HNF4A ABCC8

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Diabetes MODY Type 2, Sequencing GCK Gene Panel

Spain.

By Reference Laboratory Genetics

This panel specifically test the GCK gene.

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Diabetes MODY Type 2 , Deletions-Duplications (MLPA) GCK Gene Panel

Spain.

By Reference Laboratory Genetics

This panel specifically test the GCK gene.

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Diabetes MODY Types 1-2-3 , Deletions-Duplications (MLPA) HNF4A, GCK, HNF1A Genes Panel

Spain.

By Reference Laboratory Genetics Diabetes MODY Types 1-2-3 , Deletions-Duplications (MLPA) HNF4A, GCK, HNF1A Genes that also includes the following genes: HNF1A GCK HNF4A

More info about this panel

Diabetes MODY, Panel Massive Sequencing (NGS) 11 Genes Panel

Spain.

By Reference Laboratory Genetics Diabetes MODY, Panel Massive Sequencing (NGS) 11 Genes that also includes the following genes: BLK SLC2A2 HNF1A HNF1B KLF11 GCK HNF4A PDX1 KCNJ11 NEUROD1

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Permanent Neonatal Diabetes Mellitus , Panel Massive Sequencing (NGS) 16 Genes Panel

Spain.

By Reference Laboratory Genetics Permanent Neonatal Diabetes Mellitus , Panel Massive Sequencing (NGS) 16 Genes that also includes the following genes: SLC19A2 HNF1B WFS1 NEUROG3 RFX6 PTF1A GLIS3 EIF2AK3 GATA6 GCK

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Hyperinsulinism-Hyperammonemia syndrome , Panel Massive Sequencing (NGS) 12 Genes Panel

Spain.

By Reference Laboratory Genetics Hyperinsulinism-Hyperammonemia syndrome , Panel Massive Sequencing (NGS) 12 Genes that also includes the following genes: SLC16A1 SLC25A15 HNF1A UCP2 GCK GLUD1 HADH HNF4A ABCC8 INSR

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Familial Hypoglycemia Hyperinsulinemia , Panel Massive Sequencing (NGS) 7 Genes Panel

Spain.

By Reference Laboratory Genetics Familial Hypoglycemia Hyperinsulinemia , Panel Massive Sequencing (NGS) 7 Genes that also includes the following genes: SLC16A1 GCK GLUD1 HADH ABCC8 INSR KCNJ11

More info about this panel

Maturity-onset diabetes of the young, type 2 Panel

Germany.

By Labor Dr. Wisplinghoff

This panel specifically test the GCK gene.

More info about this panel

Permanent Neonatal Diabetes Mellitus: gene sequencing panel Panel

Canada.

By CEN4GEN Institute for Genomics and Molecular Diagnostics Permanent Neonatal Diabetes Mellitus: gene sequencing panel that also includes the following genes: GCK ABCC8 INS PDX1 KCNJ11

More info about this panel

Familial Hyperinsulinism: gene sequencing panel Panel

Canada.

By CEN4GEN Institute for Genomics and Molecular Diagnostics Familial Hyperinsulinism: gene sequencing panel that also includes the following genes: UCP2 GCK GLUD1 HADH HNF4A ABCC8 KCNJ11

More info about this panel


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