FOXN1 gene related symptoms and diseases
All the information presented here about the FOXN1 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,ORPHANET,HGNC,OMIM, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to FOXN1 gene
Symptoms // Phenotype | % Cases |
---|---|
Immunodeficiency | Very Common - Between 80% and 100% cases |
Alopecia | Very Common - Between 80% and 100% cases |
Nail dystrophy | Very Common - Between 80% and 100% cases |
Hypotrichosis | Very Common - Between 80% and 100% cases |
Ridged nail | Very Common - Between 80% and 100% cases |
Other less frequent symptoms and clinical features
Patients with FOXN1 gene alterations may also develop some of the following symptoms and phenotypes:Commonly - More than 50% cases
- Decrease in T cell count
- Nail pits
- Severe T-cell immunodeficiency
- Congenital alopecia totalis
- Decreased proportion circulating T-helper cells
Rare diseases associated to FOXN1 gene
Here you will find a list of rare diseases related to the FOXN1. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
ALYMPHOID CYSTIC THYMIC DYSGENESIS
Alternate names
ALYMPHOID CYSTIC THYMIC DYSGENESIS Is also known as winged helix deficiency, severe t-cell immunodeficiency-congenital alopecia-nail dystrophy syndrome, foxn1 deficiency
Description
Alymphoid cystic thymic dysgenesis is a rare, genetic, primary immunodeficiency due to a defect in adaptive immunity characterized by the triad of congenital athymia (resulting in severe T-cell immunodeficiency), congenital alopecia totalis and nail dystrophy. Patients present neonatal or infantile-onset, severe, recurrent, life-threatening infections and low or absent circulating T cells. Additional features reported include erythroderma, lymphoadenopathy, diarrhea and failure to thrive.
Most common symptoms of ALYMPHOID CYSTIC THYMIC DYSGENESIS
- Immunodeficiency
- Alopecia
- Nail dystrophy
- Hypotrichosis
- Ridged nail
More info about ALYMPHOID CYSTIC THYMIC DYSGENESIS
Search interest in FOXN1
Potential gene panels for FOXN1 gene
Severe Combined Immunodeficiency and T Cell Disorders Panel by next-generation sequencing (NGS) Panel
By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center Severe Combined Immunodeficiency and T Cell Disorders Panel by next-generation sequencing (NGS) that also includes the following genes: RMRP STAT5B STIM1 TBX1 FOXN1 ZAP70 CD3D CD3E DCLRE1C ADA
More info about this panelFOXN1 Sequencing Panel
By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center
This panel specifically test the FOXN1 gene.
More info about this panelSevere Combined Immunodeficiency and T Cell Disorders Deletion/Duplication Panel Panel
By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center Severe Combined Immunodeficiency and T Cell Disorders Deletion/Duplication Panel that also includes the following genes: RMRP STAT5B STIM1 TBX1 FOXN1 ZAP70 CD3D CD3E ADA NHEJ1
More info about this panelFOXN1 Deletion/duplication analysis Panel
By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center
This panel specifically test the FOXN1 gene.
More info about this panelSevere combined immunodeficiency Seq + Del/Dup Panel Panel
By Division of Genomic Diagnostics The Children's Hospital of Philadelphia Severe combined immunodeficiency Seq + Del/Dup Panel that also includes the following genes: TBX1 WAS FOXN1 DCLRE1C ADA DOCK8 CHD7 NHEJ1 IKBKG IL2RG
More info about this panelSevere combined immunodeficency Seq Analysis Panel
By Division of Genomic Diagnostics The Children's Hospital of Philadelphia Severe combined immunodeficency Seq Analysis that also includes the following genes: TBX1 WAS FOXN1 DCLRE1C ADA DOCK8 CHD7 NHEJ1 IKBKG IL2RG
More info about this panelSevere combined immunodeficiency Del/dup Panel Panel
By Division of Genomic Diagnostics The Children's Hospital of Philadelphia Severe combined immunodeficiency Del/dup Panel that also includes the following genes: TBX1 WAS FOXN1 DCLRE1C ADA DOCK8 CHD7 NHEJ1 IKBKG IL2RG
More info about this panelT-cell immunodeficiency, congenital alopecia, and nail dystrophy (sequence analysis of FOXN1 gene) Panel
By CGC Genetics
This panel specifically test the FOXN1 gene.
More info about this panelB-positive SCID panel Panel
By Centogene AG - the Rare Disease Company B-positive SCID panel that also includes the following genes: RMRP STAT5B STIM1 TBX1 FOXN1 ZAP70 CD3D CD3E CD247 ORAI1
More info about this panelComprehensive SCID panel Panel
By Centogene AG - the Rare Disease Company Comprehensive SCID panel that also includes the following genes: RMRP STAT5B STIM1 TBX1 FOXN1 ZAP70 CD3D CD3E CD247 DCLRE1C
More info about this panelT-cell immunodeficiency, congenital alopecia, and nail dystrophy Panel
By Centogene AG - the Rare Disease Company
This panel specifically test the FOXN1 gene.
More info about this panelCombined immunodeficiencies Panel Panel
By CeGaT GmbH Combined immunodeficiencies Panel that also includes the following genes: RMRP SEMA3E STAT5B STIM1 STK4 TAPBP TBX1 THBD TNFRSF4 CD40
More info about this panelInvitae Primary Immunodeficiency Panel Panel
By Invitae Invitae Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC SEMA3E SH2D1A SH3BP2 SLC7A7 SMARCAL1 BTK STAT1 STAT2
More info about this panelInvitae Syndromic Combined Immunodeficiency (CID) Panel Panel
By Invitae Invitae Syndromic Combined Immunodeficiency (CID) Panel that also includes the following genes: RMRP SEMA3E SMARCAL1 STAT3 STAT5B STIM1 TBX1 TCN2 TERC TERT
More info about this panelSevere Combined Immunodeficiency (SCID) B+: Sequencing Panel Panel
By EGL Genetic Diagnostics Eurofins Clinical Diagnostics Severe Combined Immunodeficiency (SCID) B+: Sequencing Panel that also includes the following genes: STAT5B STIM1 TBX1 FOXN1 ZAP70 CD3D CD3E CD247 ORAI1 IL2RG
More info about this panelSevere Combined Immunodeficiency (SCID) B+/B-: Sequencing Panel Panel
By EGL Genetic Diagnostics Eurofins Clinical Diagnostics Severe Combined Immunodeficiency (SCID) B+/B-: Sequencing Panel that also includes the following genes: STAT5B STIM1 TBX1 FOXN1 ZAP70 CD3D CD3E CD247 DCLRE1C ADA
More info about this panelFOXN1 Panel
By Fulgent Genetics Fulgent Genetics
This panel specifically test the FOXN1 gene.
More info about this panelPrimary Immunodeficiency Panel Panel
By Blueprint Genetics Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC CFB BLM SH2D1A SLC7A7 SMARCAL1 SMARCD2 SRP72 BTK
More info about this panelSevere Combined Immunodeficiency Panel Panel
By Blueprint Genetics Severe Combined Immunodeficiency Panel that also includes the following genes: RMRP BLM SH2D1A SMARCAL1 STAT1 STAT2 STAT3 STAT5B STIM1 STK4
More info about this panelSEVERE COMBINED IMMUNODEFICIENCY (SCID): NGS PANEL Panel
By Laboratorio de Genetica Clinica SL SEVERE COMBINED IMMUNODEFICIENCY (SCID): NGS PANEL that also includes the following genes: STAT1 STIM1 FOXN1 ZAP70 CARD11 CD3D CD3E CD247 DCLRE1C ADA
More info about this panelSevere Combined Immune Deficiency (SCID) , Panel Massive Sequencing (NGS) 18 Genes Panel
By Reference Laboratory Genetics Severe Combined Immune Deficiency (SCID) , Panel Massive Sequencing (NGS) 18 Genes that also includes the following genes: STAT5B STIM1 FOXN1 ZAP70 CD3D CD3E DCLRE1C ADA NHEJ1 ORAI1
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