FLT4 gene related symptoms and diseases
All the information presented here about the FLT4 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,OMIM,HGNC,ORPHANET, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to FLT4 gene
Symptoms // Phenotype | % Cases |
---|---|
Neoplasm | Uncommon - Between 30% and 50% cases |
Tetralogy of Fallot | Uncommon - Between 30% and 50% cases |
Ventricular septal defect | Uncommon - Between 30% and 50% cases |
Hemangioma | Uncommon - Between 30% and 50% cases |
Arrhythmia | Uncommon - Between 30% and 50% cases |
Other less frequent symptoms and clinical features
Patients with FLT4 gene alterations may also develop some of the following symptoms and phenotypes:Not very common - Between 30% and 50% cases
- Pulmonic stenosis
Rarely - Less than 30% cases
- Increased body weight
- Right ventricular hypertrophy
- Pulmonary valve atresia
- Overriding aorta
- Endocarditis
- Abnormal nasal morphology
- Right ventricular failure
And 100 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to FLT4 gene
Here you will find a list of rare diseases related to the FLT4. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
POLYCYSTIC OVARY SYNDROME 1; PCOS1
Alternate names
POLYCYSTIC OVARY SYNDROME 1; PCOS1 Is also known as pco, pco1, hyperandrogenemia, stein-leventhal syndrome, pcos
Description
a health problem that can affect a woman's menstrual cycle, fertility, hormones, insulin production, heart, blood vessels, and appearance
Most common symptoms of POLYCYSTIC OVARY SYNDROME 1; PCOS1
- Neoplasm
- Abnormality of metabolism/homeostasis
- Obesity
- Diabetes mellitus
- Apnea
More info about POLYCYSTIC OVARY SYNDROME 1; PCOS1
TETRALOGY OF FALLOT
Description
Tetralogy of Fallot is a congenital cardiac malformation that consists of an interventricular communication, also known as a ventricular septal defect, obstruction of the right ventricular outflow tract, override of the ventricular septum by the aortic root, and right ventricular hypertrophy.
Most common symptoms of TETRALOGY OF FALLOT
- Growth delay
- Muscle weakness
- Cryptorchidism
- Anemia
- Brachydactyly
More info about TETRALOGY OF FALLOT
MILROY DISEASE
Alternate names
MILROY DISEASE Is also known as hereditary lymphedema type i, nonne-milroy lymphedema, congenital primary lymphedema
Description
Milroy disease is a frequent form of primary lymphedema (see this term) characterized generally by painless, chronic lower-limb lymphedema found at birth or developing in the early neonatal period.
More info about MILROY DISEASE
SOURCES: ORPHANET
LYMPHEDEMA, HEREDITARY, IA; LMPH1A
Alternate names
LYMPHEDEMA, HEREDITARY, IA; LMPH1A Is also known as primary congenital lymphedema, pcl, nonne-milroy lymphedema, lymphedema, early-onset, milroy disease
Description
Hereditary primary lymphedema is caused by anatomic or functional defects in the lymphatic system, resulting in chronic swelling of body parts. There may be accompanying nail and skin changes, such as nail dysplasia or papillomatosis. Onset is usually at birth or in early childhood but can occur later, and the severity is variable (summary by Gordon et al., 2013 and Balboa-Beltran et al., 2014).
Most common symptoms of LYMPHEDEMA, HEREDITARY, IA; LMPH1A
- Scoliosis
- Strabismus
- Cleft palate
- Ptosis
- Ventricular septal defect
More info about LYMPHEDEMA, HEREDITARY, IA; LMPH1A
SOURCES: OMIM
HEMANGIOMA, CAPILLARY INFANTILE
Alternate names
HEMANGIOMA, CAPILLARY INFANTILE Is also known as hci, hemangioma, hereditary capillary
Description
Capillary hemangiomas are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births (Mulliken and Young, 1988). Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma. Hemangiomas are classified as distinct from vascular malformations (see, e.g., CMC1, {163000}; {108010}; and CCM, {116860}), in that the latter are present from birth, tend to grow with the individual, do not regress, and show normal rates of endothelial cell turnover (Spring and Bentz, 2005; Legiehn and Heran, 2006). Legiehn and Heran (2006) noted that the term 'hemangioma' in adults is considered inaccurate and should be discarded.Most hemangiomas occur sporadically, but some families with autosomal dominant inheritance have been reported (Walter et al., 1999).
Most common symptoms of HEMANGIOMA, CAPILLARY INFANTILE
- Neoplasm
- Hemangioma
- Capillary hemangioma
More info about HEMANGIOMA, CAPILLARY INFANTILE
Search interest in FLT4
Potential gene panels for FLT4 gene
NGS Vascular Disorders Panel Panel
By Greenwood Genetic Center Diagnostic Laboratories Greenwood Genetic Center NGS Vascular Disorders Panel that also includes the following genes: SOX18 TEK VEGFC GLMN KRIT1 STAMBP GJC2 ACVRL1 CCM2 CCBE1
More info about this panelFLT4 Panel
By Institute for Human Genetics University Clinic Freiburg
This panel specifically test the FLT4 gene.
More info about this panelLymphedema NGS Multi-Gene Panel (36 Genes) Panel
By Laboratory of genome diagnostics Academic Medical Center, University of Amsterdam Lymphedema NGS Multi-Gene Panel (36 Genes) that also includes the following genes: BRAF SOS1 SOX18 VEGFC CBL SHOC2 GJC2 TUBGCP6 CDK19 SPRED1
More info about this panelFLT4. Complete sequencing Panel
By Instituto de Medicina Genomica Instituto de Medicina Genomica
This panel specifically test the FLT4 gene.
More info about this panelMilroy disease (sequence analysis of 17 to 26 exon of FLT4 gene) Panel
By CGC Genetics
This panel specifically test the FLT4 gene.
More info about this panelMilroy disease (sequence analysis of FLT4 gene) Panel
By CGC Genetics
This panel specifically test the FLT4 gene.
More info about this panelLymphedema Sequencing Panel with CNV Detection Panel
By PreventionGenetics PreventionGenetics Lymphedema Sequencing Panel with CNV Detection that also includes the following genes: SOX18 VEGFC GJC2 FAT4 PIEZO1 CCBE1 FLT4 FOXC2 GATA2 GJA1
More info about this panelMilroy Disease (Lymphedema Type I) via FLT4 Gene Sequencing with CNV Detection Panel
By PreventionGenetics PreventionGenetics
This panel specifically test the FLT4 gene.
More info about this panelLymphedema, hereditary, type 1A Panel
By Centogene AG - the Rare Disease Company
This panel specifically test the FLT4 gene.
More info about this panelSingle gene testing FLT4 Panel
By CeGaT GmbH
This panel specifically test the FLT4 gene.
More info about this panelVascular and lymphatic disorders Panel Panel
By CeGaT GmbH Vascular and lymphatic disorders Panel that also includes the following genes: SOX18 TREX1 SERPING1 VEGFC KRIT1 GJC2 ACVRL1 CCM2 FAT4 CCBE1
More info about this panelPrimary lymphedema and Hydrops fetalis Panel
By Center for Human Genetics Cliniques Universitaires Saint Luc Primary lymphedema and Hydrops fetalis that also includes the following genes: SOS1 SOX18 VEGFC GJC2 FAT4 PIEZO1 CCBE1 EPHB4 FLT4 FOXC2
More info about this panelMilroy disease: FLT4 (VEGFR3) gene sequence analysis (exons 17-26) Panel
By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases
This panel specifically test the FLT4 gene.
More info about this panelLYMPHEDEMA Panel
By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases LYMPHEDEMA that also includes the following genes: SOX18 ZMPSTE24 GJC2 CCBE1 FLT4 FOXC2 GATA2 KIF11 LMNA
More info about this panelFLT4 Panel
By Fulgent Genetics Fulgent Genetics
This panel specifically test the FLT4 gene.
More info about this panelLymphatic Malformations and Related Disorders Panel Panel
By Blueprint Genetics Lymphatic Malformations and Related Disorders Panel that also includes the following genes: SOX18 GJC2 FAT4 PIEZO1 CCBE1 FLT4 FOXC2 GATA2 KIF11 PIK3CA
More info about this panelHereditary lymphedema type I Panel
By Bioarray
This panel specifically test the FLT4 gene.
More info about this panelSolid Tumor Gene Set Panel
By Genomics and Pathology Services Washington University in St. Louis Solid Tumor Gene Set that also includes the following genes: RIT1 ROS1 RXRA FOXL2 BRAF BRCA1 BRCA2 SMARCA4 SMARCB1 KDM5C
More info about this panelThoracic Tumors Gene Set Panel
By Genomics and Pathology Services Washington University in St. Louis Thoracic Tumors Gene Set that also includes the following genes: RIT1 ROS1 BRAF SMARCA4 STK11 MED12 TP53 TSC1 TSC2 KMT2C
More info about this panelFoundationOne® Heme Panel
By Foundation Medicine, Inc. FoundationOne® Heme that also includes the following genes: BCL6 BCL7A ROS1 RUNX1 BLM SDHA SDHB SDHC SDHD SF3B1
More info about this panelNeoTYPE® Discovery Profile for Solid Tumors Panel
By NeoGenomics Laboratories NeoGenomics Laboratories, Inc. NeoTYPE® Discovery Profile for Solid Tumors that also includes the following genes: BCL6 ROS1 RUNX1 BLM SDHA SDHB SDHC SDHD SF3B1 FOXL2
More info about this panelCaris MI TumorSeek 592-Gene NGS Panel Panel
By Caris Life Sciences Caris MI TumorSeek 592-Gene NGS Panel that also includes the following genes: BCL6 BCL7A BCL9 BCR ROS1 RPL10 RPL22 RPL5 RPN1 RUNX1
More info about this panelMILROY SYNDROME Panel
By Laboratorio de Genetica Clinica SL MILROY SYNDROME that also includes the following genes: GJC2 FLT4
More info about this panelMILROY SYNDROME SANGER PANEL Panel
By Laboratorio de Genetica Clinica SL MILROY SYNDROME SANGER PANEL that also includes the following genes: VEGFC GJC2 FLT4
More info about this panelProvidence Personalized Medicine Panel - Solid Tumor Panel
By Providence Regional Laboratories Providence Health and Services Providence Personalized Medicine Panel - Solid Tumor that also includes the following genes: BCR ROS1 RUNX1 SDHA SDHB SDHC SDHD SF3B1 SRSF2 FOXL2
More info about this panelMilroy Disease , Sequencing FLT4 (VEGFR3) Gene Panel
By Reference Laboratory Genetics
This panel specifically test the FLT4 gene.
More info about this panelMilroy Disease, Sequencing Exons (17-28) FLT4 Gene Panel
By Reference Laboratory Genetics
This panel specifically test the FLT4 gene.
More info about this panelLymphedema-Lethal Restrictive Dermopathy , Panel Massive Sequencing (NGS) 7 Genes Panel
By Reference Laboratory Genetics Lymphedema-Lethal Restrictive Dermopathy , Panel Massive Sequencing (NGS) 7 Genes that also includes the following genes: SOX18 VEGFC ZMPSTE24 FLT4 FOXC2 GATA2 KIF11
More info about this panel152 Integrated Advantage NGS Solid Tumor Panel Panel
By Integrated Molecular Diagnostics Pathology, Inc. 152 Integrated Advantage NGS Solid Tumor Panel that also includes the following genes: ROS1 RRM1 SLCO1B1 BRAF BRCA1 SLC29A1 BRCA2 SMO SPARC SRC
More info about this panelTempus xT assay Panel
By Tempus Labs, Inc. Tempus xT assay that also includes the following genes: BCL6 RIT1 BCL7A BCR ROS1 RPL5 RPS15 RPS6KB1 RUNX1 RXRA
More info about this panelTempus xO assay Panel
By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2
More info about this panelMilroy Disease: gene sequencing Panel
By CEN4GEN Institute for Genomics and Molecular Diagnostics
This panel specifically test the FLT4 gene.
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