FASLG gene related symptoms and diseases

All the information presented here about the FASLG gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: OMIM,ORPHANET,HGNC,NCBIGENE, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to FASLG gene

Symptoms // Phenotype % Cases
Carcinoma Very Common - Between 80% and 100% cases
Neoplasm Very Common - Between 80% and 100% cases
Leukemia Very Common - Between 80% and 100% cases
Antinuclear antibody positivity Uncommon - Between 30% and 50% cases
Lymphocytosis Uncommon - Between 30% and 50% cases

Other less frequent symptoms and clinical features

Patients with FASLG gene alterations may also develop some of the following symptoms and phenotypes:
  • Not very common - Between 30% and 50% cases

  • Extramedullary hematopoiesis
  • Chronic lymphatic leukemia
  • Generalized edema
  • Multiple myeloma
  • Uveitis
  • Hepatocellular carcinoma
  • Increased IgA level
  • Autoimmune thrombocytopenia

And 56 more phenotypes, you can get all of them using our tools for rare diseases.

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Rare diseases associated to FASLG gene

Here you will find a list of rare diseases related to the FASLG. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


LUNG CANCER


Description

Lung cancer is the leading cause of cancer deaths in the U.S. and worldwide. The 2 major forms of lung cancer are nonsmall cell lung cancer and small cell lung cancer (see {182280}), which account for 85% and 15% of all lung cancers, respectively. Nonsmall cell lung cancer can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. Cigarette smoking causes all types of lung cancer, but it is most strongly linked with small cell lung cancer and squamous cell carcinoma. Adenocarcinoma is the most common type in patients who have never smoked. Nonsmall cell lung cancer is often diagnosed at an advanced stage and has a poor prognosis (summary by Herbst et al., 2008).

Most common symptoms of LUNG CANCER

  • Neoplasm
  • Pain
  • Fatigue
  • Respiratory distress
  • Diarrhea


More info about LUNG CANCER

SOURCES: OMIM

AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME


Alternate names

AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME Is also known as alps, autoimmune lymphoproliferative syndrome, type i, autosomal dominant, fas deficiency, canale-smith syndrome

Description

Autoimmune lymphoproliferative syndrome (ALPS) is a rare, inherited disorder characterized by non-malignant lymphoproliferation, multilineage cytopenias, and a lifelong increased risk of Hodgkin's and non-Hodgkin's lymphoma.

Most common symptoms of AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME

  • Neoplasm
  • Anemia
  • Hepatomegaly
  • Edema
  • Splenomegaly


More info about AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME

SOURCES: OMIM ORPHANET


Potential gene panels for FASLG gene

FASLG Sequencing Panel

United States.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center

This panel specifically test the FASLG gene.

More info about this panel

Autoimmune Lymphoproliferative Syndrome Panel by next-generation sequencing (NGS) Panel

United States.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center Autoimmune Lymphoproliferative Syndrome Panel by next-generation sequencing (NGS) that also includes the following genes: FAS FASLG CASP10 CASP8 MAGT1 FADD ITK KRAS NRAS

More info about this panel

Autoimmune Lymphoproliferative Syndrome Deletion/Duplication Panel Panel

United States.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center Autoimmune Lymphoproliferative Syndrome Deletion/Duplication Panel that also includes the following genes: FAS FASLG CASP10 CASP8 MAGT1 FADD ITK KRAS NRAS

More info about this panel

FASLG Deletion/duplication analysis Panel

United States.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center

This panel specifically test the FASLG gene.

More info about this panel

Tier 2: Hereditary Lymphoma and Immunodeficiency Panel Panel

United States.

By Genetic Services Laboratory University of Chicago Tier 2: Hereditary Lymphoma and Immunodeficiency Panel that also includes the following genes: BLM SH2D1A BRCA1 BRCA2 STXBP2 FAS CD27 FASLG WAS IKZF1

More info about this panel

FASLG. Complete sequencing Panel

Spain.

By Instituto de Medicina Genomica Instituto de Medicina Genomica

This panel specifically test the FASLG gene.

More info about this panel

Autoimmune lymphoproliferative syndrome (sequence analysis of FASLG gene) Panel

Portugal.

By CGC Genetics

This panel specifically test the FASLG gene.

More info about this panel

Autoimmune lymphoproliferative syndrome (deletion/duplication analysis of FASLG) Panel

Portugal.

By CGC Genetics

This panel specifically test the FASLG gene.

More info about this panel

Autoimmune lymphoproliferative syndrome (deletion/duplication analysis of FASLG) Panel

Portugal.

By CGC Genetics

This panel specifically test the FASLG gene.

More info about this panel

Autoimmune Lymphoproliferative Syndrome/ALPS Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Autoimmune Lymphoproliferative Syndrome/ALPS Sequencing Panel with CNV Detection that also includes the following genes: SH2D1A STAT3 FAS FASLG CASP10 CASP8 LRBA CTLA4 MAGT1 FADD

More info about this panel

FASLG Panel

Netherlands.

By Genome Diagnostics Laboratory University Medical Center Utrecht

This panel specifically test the FASLG gene.

More info about this panel

ALPS/autoimmunity panel Panel

Netherlands.

By Genome Diagnostics Laboratory University Medical Center Utrecht ALPS/autoimmunity panel that also includes the following genes: FAS FASLG ITCH CASP10 CASP8 LRBA FADD AIRE IL2RA FOXP3

More info about this panel

Autoimmune lymphoproliferative syndrome Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the FASLG gene.

More info about this panel

Immune dysregulation Panel Panel

Germany.

By CeGaT GmbH Immune dysregulation Panel that also includes the following genes: SH2D1A STX11 STXBP2 FAS FASLG TREX1 ITCH CASP10 CASP8 CARD11

More info about this panel

Invitae Monogenic Autoimmunity Panel Panel

United States.

By Invitae Invitae Monogenic Autoimmunity Panel that also includes the following genes: RMRP SH2D1A SLC7A7 BTK STAT1 STAT3 STAT5B STIM1 STX11 STXBP2

More info about this panel

Invitae Primary Immunodeficiency Panel Panel

United States.

By Invitae Invitae Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC SEMA3E SH2D1A SH3BP2 SLC7A7 SMARCAL1 BTK STAT1 STAT2

More info about this panel

Invitae Autoimmune Lymphoproliferative Disorders (ALPS) Panel Panel

United States.

By Invitae Invitae Autoimmune Lymphoproliferative Disorders (ALPS) Panel that also includes the following genes: FAS FASLG CASP8 CTLA4 MAGT1 ITK PIK3CD PRKCD

More info about this panel

FASLG Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the FASLG gene.

More info about this panel

Primary Immunodeficiency Panel Panel

Finland.

By Blueprint Genetics Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC CFB BLM SH2D1A SLC7A7 SMARCAL1 SMARCD2 SRP72 BTK

More info about this panel

Hemophagocytic Lymphohistiocytosis Panel Panel

Finland.

By Blueprint Genetics Hemophagocytic Lymphohistiocytosis Panel that also includes the following genes: SH2D1A STX11 STXBP2 FAS FASLG LYST UNC13D MAGT1 FADD XIAP

More info about this panel

Comprehensive Hematology Panel Panel

Finland.

By Blueprint Genetics Comprehensive Hematology Panel that also includes the following genes: RHAG RIT1 RPL11 RPL15 RPL35A RPL5 RPS10 RPS19 RPS24 RPS26

More info about this panel

Autoimmune lymphoproliferative syndrome type 1B Panel

Spain.

By Bioarray

This panel specifically test the FASLG gene.

More info about this panel

LYMPHOPROLIFERATIVE SYNDROME, AUTOIMMUNE Panel

Spain.

By Laboratorio de Genetica Clinica SL LYMPHOPROLIFERATIVE SYNDROME, AUTOIMMUNE that also includes the following genes: FAS FASLG CASP10 CASP8 NRAS

More info about this panel

AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME NGS PANEL Panel

Spain.

By Laboratorio de Genetica Clinica SL AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME NGS PANEL that also includes the following genes: SH2D1A STAT3 FAS FASLG CASP10 CASP8 CTLA4 MAGT1 FADD XIAP

More info about this panel

Autoimmune Lymphoproliferative Syndrome Type IB, Sequencing FASLG Gene Panel

Spain.

By Reference Laboratory Genetics

This panel specifically test the FASLG gene.

More info about this panel

Autosomic Autoimmune Lymphoproliferative Syndrome , Panel Massive Sequencing (NGS) 10 Genes Panel

Spain.

By Reference Laboratory Genetics Autosomic Autoimmune Lymphoproliferative Syndrome , Panel Massive Sequencing (NGS) 10 Genes that also includes the following genes: FAS FASLG CASP10 CASP8 CTLA4 MAGT1 FADD ITK KRAS NRAS

More info about this panel

Tempus xO assay Panel

United States.

By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2

More info about this panel


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